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F8: coagulation factor VIII

1 protein, 211 patents, 16 drugs, 520 trials, 1,743 NIH grants and 10,914 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF8HGNC
Namecoagulation factor VIIIHGNC
NCBI Gene ID2157NCBI Gene
HGNC IDHGNC:3546HGNC
EnsemblENSG00000185010NCBI Gene
AliasesAHF, DXS1253E, F8B, F8C, FVIII, HEMA, THPH13NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00451Coagulation factor VIII2,35127Ensembl, GeneID, HGNCUniProt

Patents 211

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4775679 A22026-07-1526P00451Espacenet
JP 2026516710 A2026-05-2695P00451Espacenet
JP 2026067851 A2026-04-21409P00451Espacenet
EP 4698655 A12026-02-2595P00451Espacenet
JP 2026002894 A2026-01-08218P00451Espacenet
JP 2025541179 A2025-12-1834P00451Espacenet
JP 2025169942 A2025-11-14907P00451Espacenet
EP 4640849 A22025-10-291169P00451Espacenet
EP 4641201 A22025-10-297822P00451Espacenet
EP 4630459 A12025-10-1534P00451Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANTIHEMOPHILIC FACTOR, PEGYLATED (MW 20000) HUMAN SEQUENCE RECOMBINANTCHEMBL4594584Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
DAMOCTOCOG ALFA PEGOLCHEMBL5315069Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
DROTRECOGIN ALFA (ACTIVATED)CHEMBL2109065Coagulation factor VIII inhibitorINHIBITORChEMBL
EFANESOCTOCOG ALFACHEMBL5095275Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
EFMOROCTOCOG ALFACHEMBL4297945Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
GIROCTOCOGENE FITELPARVOVECCHEMBL4298194Coagulation factor VIII exogenous geneEXOGENOUS GENEChEMBL
HUMAN COAGULATION FACTOR VIIICHEMBL2108175Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
LONOCTOCOG ALFACHEMBL4594603Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
MOROCTOCOG ALFACHEMBL2109137Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL
OCTOCOG ALFACHEMBL4297873Coagulation factor VIII exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 520

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07446010OCTOCOG ALFAClinicalTrials.gov
NCT07437404MOROCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07437404OCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07437404OMFILOCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07129343MOROCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07129343OCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07129343EFMOROCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07129343ANTIHEMOPHILIC FACTOR, PEGYLATED (MW 20000) HUMAN SEQUENCE RECOMBINANTPHASE3ClinicalTrials.gov
NCT07129343LONOCTOCOG ALFAPHASE3ClinicalTrials.gov
NCT07088458DAMOCTOCOG ALFA PEGOLClinicalTrials.gov

NIH grants 1743

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL102035Platelet-derived FVIII Gene Therapy of Hemophilia A302,025NIH's project files
R01HL131093Enhancing immune regulation in gene therapy for hemophilia152,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI142,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill122,025NIH's project files
P01HL139420Hemostasis and Thrombosis: Chemistry, Biology and Physiology82,025NIH's project files
P01HL160472Toward Safer Gene Therapy for Hemophilia A82,025NIH's project files
R01HL142975Regulation of Protein C Pathways82,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha72,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72,025NIH's project files
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases62,025NIH's project files

Papers 10914

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824064PubTator, text miningPubMed
42809655PubTator, text miningPubMed
42807383PubTator, text miningPubMed
42802432PubTator, text miningPubMed
42786990PubTator, text miningPubMed
42786406PubTator, text miningPubMed
42780952PubTator, text miningPubMed
42780053PubTator, text miningPubMed
42762471PubTator, text miningPubMed
42762060PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license