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F9: coagulation factor IX

1 protein, 319 patents, 12 drugs, 105 trials, 2,097 NIH grants and 7,474 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF9HGNC
Namecoagulation factor IXHGNC
NCBI Gene ID2158NCBI Gene
HGNC IDHGNC:3551HGNC
EnsemblENSG00000101981NCBI Gene
AliasesF9 p22, FIX, HEMB, P19, PTC, THPH8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00740Coagulation factor IX46156Ensembl, GeneID, HGNCUniProt

Patents 319

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21410P00740Espacenet
JP 2026065641 A2026-04-15378P00740Espacenet
US 12600798 B22026-04-1416P00740Espacenet
EP 4709863 A22026-03-181137P00740Espacenet
JP 2025179058 A2025-12-091735P00740Espacenet
WO 2025239324 A2025-11-201P00740Espacenet
EP 4650780 A22025-11-19414P00740Espacenet
JP 2025169942 A2025-11-14898P00740Espacenet
EP 4640849 A22025-10-2949P00740Espacenet
EP 4641201 A22025-10-29286P00740Espacenet

Drugs 12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALBUTREPENONACOG ALFACHEMBL5315076Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL
COAGULATION FACTOR IX HUMANCHEMBL4297986Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL
COAGULATION FACTOR IX RECOMBINANT HUMANCHEMBL2109205Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL
EFTRENONACOG ALFACHEMBL4594598Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL
EMICIZUMABCHEMBL3833393Coagulation factor IX and X otherOTHERChEMBL
ETRANACOGENE DEZAPARVOVECCHEMBL5095451Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL
FIDANACOGENE ELAPARVOVECCHEMBL3990034Coagulation factor IX exogenous geneEXOGENOUS GENEChEMBL
NONACOG BETA PEGOLCHEMBL2108348Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL
PEGNIVACOGINCHEMBL2107870Coagulation factor IX inhibitorINHIBITORChEMBL
PROTHROMBIN COMPLEX CONCENTRATECHEMBL6068614Coagulation factor IX exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 105

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07439055EMICIZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT07416604EMICIZUMABPHASE3ClinicalTrials.gov
NCT07094087PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT06938659EMICIZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT06673056TRENONACOG ALFAPHASE3ClinicalTrials.gov
NCT06224907VALOCTOCOGENE ROXAPARVOVECPHASE3ClinicalTrials.gov
NCT06158334EFTRENONACOG ALFAClinicalTrials.gov
NCT06155955EMICIZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT06104826EMICIZUMABClinicalTrials.gov
NCT06008938ETRANACOGENE DEZAPARVOVECClinicalTrials.gov

NIH grants 2097

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI192,025NIH's project files
R01HL131093Enhancing immune regulation in gene therapy for hemophilia132,025NIH's project files
R01HL064274Hepatic gene transfer for the treatment of hemophilia B and other genetic diseases112,025NIH's project files
P01HL139420Hemostasis and Thrombosis: Chemistry, Biology and Physiology82,025NIH's project files
R01HL144113Contact Pathway Activation on Vascular Devices82,025NIH's project files
R01GM082946AAV capsids and their cellular interactions62,025NIH's project files
R01NS076991Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and Leukodystrophies62,025NIH's project files
T32HL007439Hematology Clinical Research Training Program62,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha52,025NIH's project files

Papers 7474

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42792750PubTator, text miningPubMed
42787633PubTator, text miningPubMed
42768248PubTator, text miningPubMed
42759140PubTator, text miningPubMed
42750114PubTator, text miningPubMed
42749889PubTator, text miningPubMed
42716226PubTator, text miningPubMed
42716225PubTator, text miningPubMed
42703036PubTator, text miningPubMed
42656610PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license