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F10: coagulation factor X

1 protein, 213 patents, 16 drugs, 441 trials, 3,950 NIH grants and 17,145 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF10HGNC
Namecoagulation factor XHGNC
NCBI Gene ID2159NCBI Gene
HGNC IDHGNC:3528HGNC
EnsemblENSG00000126218NCBI Gene
AliasesFX, FXA, fXNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00742Coagulation factor X488190Ensembl, GeneID, HGNCUniProt

Patents 213

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4771144 A12026-07-081P00742Espacenet
JP 2026002816 A2026-01-081P00742Espacenet
WO 2025253121 A12025-12-111P00742Espacenet
WO 2025239324 A2025-11-205P00742Espacenet
EP 4650780 A22025-11-199652P00742Espacenet
JP 2025169942 A2025-11-14909P00742Espacenet
EP 4641201 A22025-10-299909P00742Espacenet
JP 2025147176 A2025-10-064957P00742Espacenet
JP 2025529142 A2025-09-046306P00742Espacenet
US 12371689 B22025-07-296306P00742Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANTITHROMBIN ALFACHEMBL1201554Coagulation factor X inhibitorINHIBITORChEMBL
APIXABANCHEMBL231779Coagulation factor X inhibitorINHIBITORChEMBL
BEMIPARINCHEMBL3707365Coagulation factor X inhibitorINHIBITORChEMBL
BETRIXABANCHEMBL512351Coagulation factor X inhibitorINHIBITORChEMBL
COAGULATION FACTOR X HUMANCHEMBL4297951Coagulation factor X exogenous proteinEXOGENOUS PROTEINChEMBL
DAREXABANCHEMBL1922235Coagulation factor X inhibitorINHIBITORChEMBL
EDOXABANCHEMBL1269025Coagulation factor X inhibitorINHIBITORChEMBL
EDOXABAN TOSYLATECHEMBL2105682Coagulation factor X inhibitorINHIBITORChEMBL
EMICIZUMABCHEMBL3833393Coagulation factor IX and X otherOTHERChEMBL
IDRABIOTAPARINUX SODIUMCHEMBL4297768Coagulation factor X inhibitorINHIBITORChEMBL

Trials 441

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603700BEMIPARINClinicalTrials.gov
NCT07602062RIVAROXABANClinicalTrials.gov
NCT07575867APIXABANClinicalTrials.gov
NCT07559942APIXABANClinicalTrials.gov
NCT07511257RIVAROXABANPHASE4ClinicalTrials.gov
NCT07461545APIXABANClinicalTrials.gov
NCT07461532APIXABANClinicalTrials.gov
NCT07456085RIVAROXABANPHASE3ClinicalTrials.gov
NCT07439055EMICIZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT07434661APIXABANPHASE3ClinicalTrials.gov

NIH grants 3950

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL049413Structural basis of prothrombin activation372,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha362,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI312,025NIH's project files
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases272,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill262,025NIH's project files
ZIAAI000810Vector-Borne Diseases: Biology Of Vector Host Relationship172,025NIH's project files
P01HL139420Hemostasis and Thrombosis: Chemistry, Biology and Physiology162,025NIH's project files
R01HL139554Structural enzymology of protein C162,025NIH's project files
R01HL147821Structural enzymology of factor V activation142,025NIH's project files
P30CA012197Cancer Center Support Grant112,025NIH's project files

Papers 17145

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42813213PubTator, text miningPubMed
42803162PubTator, text miningPubMed
42793169PubTator, text miningPubMed
42786382PubTator, text miningPubMed
42746644PubTator, text miningPubMed
42741326PubTator, text miningPubMed
42739272PubTator, text miningPubMed
42739156PubTator, text miningPubMed
42737430PubTator, text miningPubMed
42727179PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license