Gene · 2160
F11: coagulation factor XI
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. F11: coagulation factor XI. Genes, record 2160. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2160
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P03951 | Coagulation factor XI | 625 | 116 | Ensembl, GeneID, HGNC |
Source UniProt
Patents115
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082949 A | 2026-05-19 | 40 | P03951 | Espacenet |
| US 12565642 B2 | 2026-03-03 | 40 | P03951 | Espacenet |
| JP 2025538873 A | 2025-12-02 | 27 | P03951 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11874 | P03951 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 912 | P03951 | Espacenet |
| JP 2025537183 A | 2025-11-14 | 41 | P03951 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12673 | P03951 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4959 | P03951 | Espacenet |
| EP 4619516 A2 | 2025-09-24 | 27 | P03951 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6307 | P03951 | Espacenet |
1 to 10 of 115
See all 115 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABELACIMAB | CHEMBL4650369 | Coagulation factor XI inhibitor | INHIBITOR | ChEMBL |
| HUMAN C1-ESTERASE INHIBITOR | CHEMBL4297549 | Coagulation factor XI inhibitor | INHIBITOR | ChEMBL |
| MILVEXIAN | CHEMBL4112929 | Coagulation factor XI inhibitor | INHIBITOR | ChEMBL |
| OSOCIMAB | CHEMBL4297905 | Coagulation factor XI negative allosteric modulator | NEGATIVE ALLOSTERIC MODULATOR | ChEMBL |
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05171075 | ABELACIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT05171049 | ABELACIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT04755283 | ABELACIMAB | PHASE2 | 2025-07-30 | ClinicalTrials.gov |
| NCT03000673 | MILVEXIAN | PHASE1/PHASE2 | 2020-12-29 | ClinicalTrials.gov |
| NCT02865720 | HUMAN C1-ESTERASE INHIBITOR | PHASE3 | 2018-12-31 | ClinicalTrials.gov |
| NCT01843530 | HUMAN C1-ESTERASE INHIBITOR | PHASE3 | ClinicalTrials.gov | |
| NCT01095497 | HUMAN C1-ESTERASE INHIBITOR | PHASE2 | 2012-03-08 | ClinicalTrials.gov |
NIH grants1,059
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | F11 papers | Newest fiscal year |
|---|---|---|---|
| R01HL101972 | Characterization of Coagulation Factor-platelet Interactions: Role of FXI | 48 | 2025 |
| R01HL144113 | Contact Pathway Activation on Vascular Devices | 19 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 6 | 2025 |
| R01HL049413 | Structural basis of prothrombin activation | 5 | 2025 |
| R01NS102721 | Contact System and Alzheimer's Disease: Mechanism and Therapeutic Potential | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P20GM103424 | Louisiana Biomedical Research Network | 4 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| R01DK099551 | New Congenital Disorders of Glycosylation: Therapy and Models | 4 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 4 | 2025 |
1 to 10 of 1,059Source NIH's project files
See all 1,059 nih grantsPapers2,705
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Potential Role of Contact Pathway Factors in Catheter-Related Thrombosis: Emerging Evidence and Therapeutic Strategies. | Biomolecules | 2026 | 42793088 | PubTator, text mining | PubMed |
| Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization. | medRxiv | 2026 | 42780090 | PubTator, text mining | PubMed |
| Integrated plasma proteomic and metabolomic profiling demonstrated specific proteins and bile acids remodeling after liver transplantation of children with biliary atresia. | Biochim Biophys Acta Proteins Proteom | 2026 | 42777789 | PubTator, text mining | PubMed |
| Perioperative management of patients on factor XI or factor XIa inhibitors. | J Thromb Haemost | 2026 | 42767508 | PubTator, text mining | PubMed |
| Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function. | J Am Heart Assoc | 2026 | 42757890 | PubTator, text mining | PubMed |
| RNAi-based therapeutics targeting the F gene in human metapneumovirus: An in-silico approach. | J Genet Eng Biotechnol | 2026 | 42749451 | PubTator, text mining | PubMed |
| Navigating Ischemic and Bleeding Risks in High Bleeding Risk Patients Undergoing Coronary Intervention. | Cardiol Res | 2026 | 42730205 | PubTator, text mining | PubMed |
| Plasma proteomics reveals the molecular features in rapidly progressive pneumoconiosis. | Front Immunol | 2026 | 42666288 | PubTator, text mining | PubMed |
| SHR-2004, a Humanized Monoclonal Antibody Targeting Factor XI, for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active-Controlled Phase 2 Study. | Am J Hematol | 2026 | 42644221 | PubTator, text mining | PubMed |
| Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study. | Diabetes Obes Metab | 2026 | 42638160 | PubTator, text mining | PubMed |
1 to 10 of 2,705
See all 2,705 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2160
GET https://conductscience.org/api/genes/v1/2160/patents?page=2