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Gene · 2160

F11: coagulation factor XI

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. F11: coagulation factor XI. Genes, record 2160. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2160

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Gene

Symbol
F11
HGNC
Name
coagulation factor XI
HGNC
NCBI Gene ID
2160
NCBI Gene
HGNC ID
HGNC:3529
HGNC
Ensembl
ENSG00000088926
NCBI Gene
Aliases
FXI, PTA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03951Coagulation factor XI625116Ensembl, GeneID, HGNC

Source UniProt

Patents115

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082949 A2026-05-1940P03951Espacenet
US 12565642 B22026-03-0340P03951Espacenet
JP 2025538873 A2025-12-0227P03951Espacenet
EP 4650780 A22025-11-1911874P03951Espacenet
JP 2025169942 A2025-11-14912P03951Espacenet
JP 2025537183 A2025-11-1441P03951Espacenet
EP 4641201 A22025-10-2912673P03951Espacenet
JP 2025147176 A2025-10-064959P03951Espacenet
EP 4619516 A22025-09-2427P03951Espacenet
JP 2025529142 A2025-09-046307P03951Espacenet

1 to 10 of 115

See all 115 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABELACIMABCHEMBL4650369Coagulation factor XI inhibitorINHIBITORChEMBL
HUMAN C1-ESTERASE INHIBITORCHEMBL4297549Coagulation factor XI inhibitorINHIBITORChEMBL
MILVEXIANCHEMBL4112929Coagulation factor XI inhibitorINHIBITORChEMBL
OSOCIMABCHEMBL4297905Coagulation factor XI negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05171075ABELACIMABPHASE3ClinicalTrials.gov
NCT05171049ABELACIMABPHASE3ClinicalTrials.gov
NCT04755283ABELACIMABPHASE22025-07-30ClinicalTrials.gov
NCT03000673MILVEXIANPHASE1/PHASE22020-12-29ClinicalTrials.gov
NCT02865720HUMAN C1-ESTERASE INHIBITORPHASE32018-12-31ClinicalTrials.gov
NCT01843530HUMAN C1-ESTERASE INHIBITORPHASE3ClinicalTrials.gov
NCT01095497HUMAN C1-ESTERASE INHIBITORPHASE22012-03-08ClinicalTrials.gov

NIH grants1,059

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleF11 papersNewest fiscal year
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI482025
R01HL144113Contact Pathway Activation on Vascular Devices192025
P51OD011092Support for National Primate Research Center62025
R01HL049413Structural basis of prothrombin activation52025
R01NS102721Contact System and Alzheimer's Disease: Mechanism and Therapeutic Potential52025
UL1TR001863Yale Clinical and Translational Science Award52025
P20GM103424Louisiana Biomedical Research Network42025
P30DK063491Diabetes Research Center (DRC)42025
R01DK099551New Congenital Disorders of Glycosylation: Therapy and Models42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025

1 to 10 of 1,059Source NIH's project files

See all 1,059 nih grants

Papers2,705

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Potential Role of Contact Pathway Factors in Catheter-Related Thrombosis: Emerging Evidence and Therapeutic Strategies.Biomolecules202642793088PubTator, text miningPubMed
Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization.medRxiv202642780090PubTator, text miningPubMed
Integrated plasma proteomic and metabolomic profiling demonstrated specific proteins and bile acids remodeling after liver transplantation of children with biliary atresia.Biochim Biophys Acta Proteins Proteom202642777789PubTator, text miningPubMed
Perioperative management of patients on factor XI or factor XIa inhibitors.J Thromb Haemost202642767508PubTator, text miningPubMed
Association of F11 Gene Variants With Cardiovascular Events and Cardiac Function.J Am Heart Assoc202642757890PubTator, text miningPubMed
RNAi-based therapeutics targeting the F gene in human metapneumovirus: An in-silico approach.J Genet Eng Biotechnol202642749451PubTator, text miningPubMed
Navigating Ischemic and Bleeding Risks in High Bleeding Risk Patients Undergoing Coronary Intervention.Cardiol Res202642730205PubTator, text miningPubMed
Plasma proteomics reveals the molecular features in rapidly progressive pneumoconiosis.Front Immunol202642666288PubTator, text miningPubMed
SHR-2004, a Humanized Monoclonal Antibody Targeting Factor XI, for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active-Controlled Phase 2 Study.Am J Hematol202642644221PubTator, text miningPubMed
Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study.Diabetes Obes Metab202642638160PubTator, text miningPubMed

1 to 10 of 2,705

See all 2,705 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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