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F12: coagulation factor XII

1 protein, 77 patents, 2 drugs, 3 trials, 2,067 NIH grants and 6,939 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF12HGNC
Namecoagulation factor XIIHGNC
NCBI Gene ID2161NCBI Gene
HGNC IDHGNC:3530HGNC
EnsemblENSG00000131187NCBI Gene
AliasesHAE3, HAEX, HAFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00748Coagulation factor XII61517Ensembl, GeneID, HGNCUniProt

Patents 77

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4729546 A12026-04-22161P00748Espacenet
JP 2026004568 A2026-01-1441713P00748Espacenet
EP 4650780 A22025-11-191458P00748Espacenet
JP 2025147176 A2025-10-064963P00748Espacenet
JP 2025529142 A2025-09-046308P00748Espacenet
US 12371689 B22025-07-296308P00748Espacenet
JP 2025517970 A2025-06-121458P00748Espacenet
KR 1020250054123 A2025-04-22128P00748Espacenet
EP 4516811 A22025-03-051P00748Espacenet
JP 2025028160 A2025-02-284963P00748Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BISMUTH SUBGALLATECHEMBL1592101Coagulation factor XII activatorACTIVATORChEMBL
HUMAN C1-ESTERASE INHIBITORCHEMBL4297549Coagulation factor XII inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02865720HUMAN C1-ESTERASE INHIBITORPHASE32018-12-31ClinicalTrials.gov
NCT01843530HUMAN C1-ESTERASE INHIBITORPHASE3ClinicalTrials.gov
NCT01095497HUMAN C1-ESTERASE INHIBITORPHASE22012-03-08ClinicalTrials.gov

NIH grants 2067

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI412,025NIH's project files
R01HL144113Contact Pathway Activation on Vascular Devices202,025NIH's project files
P30CA008748Cancer Center Support Grant102,025NIH's project files
P30DK036836Diabetes Research Center102,025NIH's project files
P51OD011092Support for National Primate Research Center102,025NIH's project files
R01NS102721Contact System and Alzheimer's Disease: Mechanism and Therapeutic Potential92,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill92,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy82,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
P30DK063491Diabetes Research Center (DRC)52,025NIH's project files

Papers 6939

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42797471PubTator, text miningPubMed
42760396PubTator, text miningPubMed
42760018PubTator, text miningPubMed
42723481PubTator, text miningPubMed
42712886PubTator, text miningPubMed
42703735PubTator, text miningPubMed
42660278PubTator, text miningPubMed
42636605PubTator, text miningPubMed
42611470PubTator, text miningPubMed
42610269PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license