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ALDH2: aldehyde dehydrogenase 2 family member

1 protein, 81 patents, 1 drug, 49 trials, 3,282 NIH grants and 5,758 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolALDH2HGNC
Namealdehyde dehydrogenase 2 family memberHGNC
NCBI Gene ID217NCBI Gene
HGNC IDHGNC:404HGNC
EnsemblENSG00000111275NCBI Gene
AliasesALDH I, ALDH-2, ALDH-E2, ALDHI, ALDMNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05091Aldehyde dehydrogenase, mitochondrial51729Ensembl, GeneID, HGNCUniProt

Patents 81

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539317 B22026-02-035P05091Espacenet
JP 2026004568 A2026-01-1437015P05091Espacenet
EP 4650780 A22025-11-191945P05091Espacenet
EP 4640849 A22025-10-29236P05091Espacenet
EP 4641201 A22025-10-291529P05091Espacenet
JP 2025519096 A2025-06-24236P05091Espacenet
JP 2025517969 A2025-06-121529P05091Espacenet
JP 2025517970 A2025-06-121945P05091Espacenet
JP 2025062604 A2025-04-143871P05091Espacenet
US 12083116 B22024-09-107P05091Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DISULFIRAMCHEMBL964Aldehyde dehydrogenase inhibitorINHIBITORChEMBL

Trials 49

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07534332DISULFIRAMPHASE2ClinicalTrials.gov
NCT07477457DISULFIRAMPHASE2ClinicalTrials.gov
NCT06319872DISULFIRAMPHASE1ClinicalTrials.gov
NCT05667415DISULFIRAMClinicalTrials.gov
NCT05210374DISULFIRAMPHASE1ClinicalTrials.gov
NCT05162001DISULFIRAMEARLY_PHASE1ClinicalTrials.gov
NCT04594343DISULFIRAMPHASE2ClinicalTrials.gov
NCT04521335DISULFIRAMPHASE1ClinicalTrials.gov
NCT04485130DISULFIRAMPHASE22023-09-13ClinicalTrials.gov
NCT04265274DISULFIRAMPHASE2ClinicalTrials.gov

NIH grants 3282

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease532,025NIH's project files
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).442,025NIH's project files
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol392,025NIH's project files
ZIAAA000036Alcohol Metabolism, Functional Consequences, Apoptosis Signaling Pathways, and Organ Damage262,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility172,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism172,025NIH's project files
ZIAAA000301Integrative genetics of behavior with high throughput technologies172,025NIH's project files
P30CA016672Cancer Center Support Grant162,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award162,025NIH's project files
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology152,025NIH's project files

Papers 5758

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818038PubTator, text miningPubMed
42799865PubTator, text miningPubMed
42772364PubTator, text miningPubMed
42771993PubTator, text miningPubMed
42755647PubTator, text miningPubMed
42752668PubTator, text miningPubMed
42732941PubTator, text miningPubMed
42723120PubTator, text miningPubMed
42715881PubTator, text miningPubMed
42713651PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license