Gene · 2180
ACSL1: acyl-CoA synthetase long chain family member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACSL1: acyl-CoA synthetase long chain family member 1. Genes, record 2180. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2180
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P33121 | Long-chain-fatty-acid--CoA ligase 1 | 698 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents86
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36293 | P33121 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36296 | P33121 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36298 | P33121 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3126 | P33121 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 242 | P33121 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 242 | P33121 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3126 | P33121 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1949 | P33121 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1951 | P33121 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1953 | P33121 | Espacenet |
1 to 10 of 86
See all 86 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,371
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACSL1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK017047 | Diabetes Research Center | 9 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 8 | 2025 |
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 8 | 2025 |
| P30DK089503 | Michigan Nutrition Obesity Research Center | 8 | 2025 |
| P30DK035816 | Nutrition Obesity Research Center | 5 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 5 | 2025 |
| ZIABC005562 | Xenobiotic receptors | 5 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,371Source NIH's project files
See all 1,371 nih grantsPapers2,026
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A myeloid-dormant metabolic transcriptome identifies a poor-prognosis subgroup in hyperdiploid multiple myeloma with targetable vulnerabilities. | Blood Cancer J | 2026 | 42827144 | PubTator, text mining | PubMed |
| Integrated bioinformatics analysis, machine learning, and experimental validation reveal that ACSL1 drives myocardial ischemia reperfusion injury via ferroptosis. | J Bioenerg Biomembr | 2026 | 42782425 | PubTator, text mining | PubMed |
| ACSL1 suppresses breast cancer progression by activating ASK1/JNK pathway-mediated autophagy-dependent ferroptosis. | Int J Biochem Cell Biol | 2026 | 42767444 | PubTator, text mining | PubMed |
| Unravelling Ferroptosis in Sepsis: A Comprehensive Integrative Transcriptomic Analysis Across Age and Disease Severity. | Bioinform Biol Insights | 2026 | 42756334 | PubTator, text mining | PubMed |
| Integrative genetic and hormonal coordination of endocarp/stone development in drupe fruit. | Hortic Res | 2026 | 42718993 | PubTator, text mining | PubMed |
| TGFBR3 regulates the expression of FATP2-ACSL1 axis related proteins and accompanies changes in the migration and invasion ability of lung cancer cells. | Front Oncol | 2026 | 42656625 | PubTator, text mining | PubMed |
| Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis. | PLoS One | 2026 | 42640988 | PubTator, text mining | PubMed |
| IL-1β-induced inflammatory stress modulates mitochondrial and metabolic gene expression in dermal fibroblasts. | Mol Biol Rep | 2026 | 42640398 | PubTator, text mining | PubMed |
| Reduced root lignification resulting from enhanced brassinosteroid signaling compromises waterlogging tolerance in Nardostachys jatamansi seedlings. | Plant Physiol Biochem | 2026 | 42617387 | PubTator, text mining | PubMed |
| Diabetes mellitus aggravates sepsis-induced lung injury by triggering NPM3-ACSL1 pathway-mediated ferroptosis. | Acta Biochim Biophys Sin (Shanghai) | 2026 | 42616601 | PubTator, text mining | PubMed |
1 to 10 of 2,026
See all 2,026 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2180
GET https://conductscience.org/api/genes/v1/2180/patents?page=2