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Gene · 2180

ACSL1: acyl-CoA synthetase long chain family member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACSL1: acyl-CoA synthetase long chain family member 1. Genes, record 2180. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2180

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Gene

Symbol
ACSL1
HGNC
Name
acyl-CoA synthetase long chain family member 1
HGNC
NCBI Gene ID
2180
NCBI Gene
HGNC ID
HGNC:3569
HGNC
Ensembl
ENSG00000151726
NCBI Gene
Aliases
ACS1, FACL1, FACL2, LACS, LACS1, LACS2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33121Long-chain-fatty-acid--CoA ligase 16980Ensembl, GeneID, HGNC

Source UniProt

Patents86

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436293P33121Espacenet
JP 2026004568 A2026-01-1436296P33121Espacenet
JP 2026004568 A2026-01-1436298P33121Espacenet
EP 4650780 A22025-11-193126P33121Espacenet
JP 2025529142 A2025-09-04242P33121Espacenet
US 12371689 B22025-07-29242P33121Espacenet
JP 2025517970 A2025-06-123126P33121Espacenet
JP 2025062604 A2025-04-141949P33121Espacenet
JP 2025062604 A2025-04-141951P33121Espacenet
JP 2025062604 A2025-04-141953P33121Espacenet

1 to 10 of 86

See all 86 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,371

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACSL1 papersNewest fiscal year
P30DK017047Diabetes Research Center92025
P30DK020572Michigan Diabetes Research Center (MDRC)82025
P30DK056350Nutrition Obesity Research Center (NORC)82025
P30DK089503Michigan Nutrition Obesity Research Center82025
P30DK035816Nutrition Obesity Research Center52025
P30ES010126UNC Center for Environmental Health and Susceptibility52025
ZIABC005562Xenobiotic receptors52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA046934University of Colorado Cancer Center Support Grant42025

1 to 10 of 1,371Source NIH's project files

See all 1,371 nih grants

Papers2,026

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A myeloid-dormant metabolic transcriptome identifies a poor-prognosis subgroup in hyperdiploid multiple myeloma with targetable vulnerabilities.Blood Cancer J202642827144PubTator, text miningPubMed
Integrated bioinformatics analysis, machine learning, and experimental validation reveal that ACSL1 drives myocardial ischemia reperfusion injury via ferroptosis.J Bioenerg Biomembr202642782425PubTator, text miningPubMed
ACSL1 suppresses breast cancer progression by activating ASK1/JNK pathway-mediated autophagy-dependent ferroptosis.Int J Biochem Cell Biol202642767444PubTator, text miningPubMed
Unravelling Ferroptosis in Sepsis: A Comprehensive Integrative Transcriptomic Analysis Across Age and Disease Severity.Bioinform Biol Insights202642756334PubTator, text miningPubMed
Integrative genetic and hormonal coordination of endocarp/stone development in drupe fruit.Hortic Res202642718993PubTator, text miningPubMed
TGFBR3 regulates the expression of FATP2-ACSL1 axis related proteins and accompanies changes in the migration and invasion ability of lung cancer cells.Front Oncol202642656625PubTator, text miningPubMed
Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis.PLoS One202642640988PubTator, text miningPubMed
IL-1β-induced inflammatory stress modulates mitochondrial and metabolic gene expression in dermal fibroblasts.Mol Biol Rep202642640398PubTator, text miningPubMed
Reduced root lignification resulting from enhanced brassinosteroid signaling compromises waterlogging tolerance in Nardostachys jatamansi seedlings.Plant Physiol Biochem202642617387PubTator, text miningPubMed
Diabetes mellitus aggravates sepsis-induced lung injury by triggering NPM3-ACSL1 pathway-mediated ferroptosis.Acta Biochim Biophys Sin (Shanghai)202642616601PubTator, text miningPubMed

1 to 10 of 2,026

See all 2,026 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2180

GET https://conductscience.org/api/genes/v1/2180/patents?page=2