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Gene · 2181

ACSL3: acyl-CoA synthetase long chain family member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACSL3: acyl-CoA synthetase long chain family member 3. Genes, record 2181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2181

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Gene

Symbol
ACSL3
HGNC
Name
acyl-CoA synthetase long chain family member 3
HGNC
NCBI Gene ID
2181
NCBI Gene
HGNC ID
HGNC:3570
HGNC
Ensembl
ENSG00000123983
NCBI Gene
Aliases
ACS3, FACL3, LACS 3, LACS3, PRO2194
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95573Fatty acid CoA ligase Acsl37200Ensembl, GeneID, HGNC

Source UniProt

Patents69

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436299O95573Espacenet
JP 2026004568 A2026-01-1436300O95573Espacenet
WO 2025257301 A12025-12-184O95573Espacenet
EP 4650780 A22025-11-197433O95573Espacenet
EP 4640849 A22025-10-291107O95573Espacenet
EP 4641201 A22025-10-297393O95573Espacenet
JP 2025529142 A2025-09-04243O95573Espacenet
US 12371689 B22025-07-29243O95573Espacenet
JP 2025519096 A2025-06-241107O95573Espacenet
JP 2025517969 A2025-06-127393O95573Espacenet

1 to 10 of 69

See all 69 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants821

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACSL3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30ES007048Environmental Exposures, Host Factors and Human Disease52025
P50CA097186The Pacific Northwest Prostate Cancer SPORE42025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025
P30DK020579Diabetes Research Center32025
P30DK056341Washington University Nutrition Obesity Research Center32025
P30ES010126UNC Center for Environmental Health and Susceptibility32025
U19AI070235Epithelial Genes in Allergic Inflammation32025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025
P01AI120943Molecular Mechanisms of Filoviral-host Interactions22025

1 to 10 of 821Source NIH's project files

See all 821 nih grants

Papers1,288

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A lymph node-targeted nanoplatform reprograms metabolic and immune microenvironments via dual ACSL3/4 inhibition in lymphatic metastatic tumors.J Control Release202642822540PubTator, text miningPubMed
Lipidome as a ferroptotic rheostat in cholangiocarcinoma: A proposed model and its current evidence base.Mol Biol Rep202642801336PubTator, text miningPubMed
ZDHHC9 regulates lipid metabolic reprogramming by mediating palmitoylation of ACSL3 to promote cetuximab resistance in colorectal cancer.Exp Cell Res202642790666PubTator, text miningPubMed
Targeting lipid metabolism-associated lncHMGCS1 suppressed cell proliferation and restored intracellular lipid homeostasis by regulating ACSL3 in gastric cancer.Eur J Pharmacol202642722057PubTator, text miningPubMed
ACSL3 at the UPR crossroads: Tactician of anti-influenza defense, target of influenza offense.Virol Sin202642697439PubTator, text miningPubMed
Linoleic acid metabolic reprogramming is linked to immunometabolic remodeling and post-transplant recurrence risk in hepatocellular carcinoma.Front Immunol202642643672PubTator, text miningPubMed
Targeting the PHB2-ACSL3 Lipid-Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer.Adv Sci (Weinh)202642627686PubTator, text miningPubMed
CSF1 inhibits ferroptosis in colorectal cancer cells by autocrine activation of the JAK/STAT3 signaling pathway.Biochem Pharmacol202642526771PubTator, text miningPubMed
Targeting NAE1 suppresses osteoclastogenesis via dual regulation of ferritinophagy and ACSL3-mediated ferroptosis.Autophagy202642495964PubTator, text miningPubMed
Toward pharmacologic therapy for glioblastoma: Characterization of the very long-chain acyl-CoA synthetase 3 (ACSVL3) inhibitor Grassofermata.bioRxiv202642465312PubTator, text miningPubMed

1 to 10 of 1,288

See all 1,288 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2181

GET https://conductscience.org/api/genes/v1/2181/patents?page=2