Gene · 2181
ACSL3: acyl-CoA synthetase long chain family member 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACSL3: acyl-CoA synthetase long chain family member 3. Genes, record 2181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2181
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95573 | Fatty acid CoA ligase Acsl3 | 720 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents69
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36299 | O95573 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36300 | O95573 | Espacenet |
| WO 2025257301 A1 | 2025-12-18 | 4 | O95573 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7433 | O95573 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1107 | O95573 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7393 | O95573 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 243 | O95573 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 243 | O95573 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1107 | O95573 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7393 | O95573 | Espacenet |
1 to 10 of 69
See all 69 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants821
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACSL3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30ES007048 | Environmental Exposures, Host Factors and Human Disease | 5 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 4 | 2025 |
| P30CA142543 | UT Southwestern Medical Center Simmons Comprehensive Cancer Center | 3 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 3 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 3 | 2025 |
| U19AI070235 | Epithelial Genes in Allergic Inflammation | 3 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 2 | 2025 |
| P01AI120943 | Molecular Mechanisms of Filoviral-host Interactions | 2 | 2025 |
1 to 10 of 821Source NIH's project files
See all 821 nih grantsPapers1,288
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A lymph node-targeted nanoplatform reprograms metabolic and immune microenvironments via dual ACSL3/4 inhibition in lymphatic metastatic tumors. | J Control Release | 2026 | 42822540 | PubTator, text mining | PubMed |
| Lipidome as a ferroptotic rheostat in cholangiocarcinoma: A proposed model and its current evidence base. | Mol Biol Rep | 2026 | 42801336 | PubTator, text mining | PubMed |
| ZDHHC9 regulates lipid metabolic reprogramming by mediating palmitoylation of ACSL3 to promote cetuximab resistance in colorectal cancer. | Exp Cell Res | 2026 | 42790666 | PubTator, text mining | PubMed |
| Targeting lipid metabolism-associated lncHMGCS1 suppressed cell proliferation and restored intracellular lipid homeostasis by regulating ACSL3 in gastric cancer. | Eur J Pharmacol | 2026 | 42722057 | PubTator, text mining | PubMed |
| ACSL3 at the UPR crossroads: Tactician of anti-influenza defense, target of influenza offense. | Virol Sin | 2026 | 42697439 | PubTator, text mining | PubMed |
| Linoleic acid metabolic reprogramming is linked to immunometabolic remodeling and post-transplant recurrence risk in hepatocellular carcinoma. | Front Immunol | 2026 | 42643672 | PubTator, text mining | PubMed |
| Targeting the PHB2-ACSL3 Lipid-Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer. | Adv Sci (Weinh) | 2026 | 42627686 | PubTator, text mining | PubMed |
| CSF1 inhibits ferroptosis in colorectal cancer cells by autocrine activation of the JAK/STAT3 signaling pathway. | Biochem Pharmacol | 2026 | 42526771 | PubTator, text mining | PubMed |
| Targeting NAE1 suppresses osteoclastogenesis via dual regulation of ferritinophagy and ACSL3-mediated ferroptosis. | Autophagy | 2026 | 42495964 | PubTator, text mining | PubMed |
| Toward pharmacologic therapy for glioblastoma: Characterization of the very long-chain acyl-CoA synthetase 3 (ACSVL3) inhibitor Grassofermata. | bioRxiv | 2026 | 42465312 | PubTator, text mining | PubMed |
1 to 10 of 1,288
See all 1,288 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2181
GET https://conductscience.org/api/genes/v1/2181/patents?page=2