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ACSL4: acyl-CoA synthetase long chain family member 4
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Gene · 2182

Papers4,043

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

81 to 100 of 4,043

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TitleJournalYearPMIDFound bySource
TRIM27-Cas9-loaded EVs suppress HCC proliferation and enhance responsiveness to anti-PD-1 therapy by promoting ACSL4-mediated ferroptosis.Cell Death Differ202642509343PubTator, text miningPubMed
Synergistic neurotoxicity of mono-butyl phthalate and bisphenol A at environmentally relevant concentrations: Multi-Omics evidence for ferroptosis via glutathione metabolism disruption in neural stem cells and brain organoids.
Chem Biol Interact202642508794PubTator, text miningPubMed
Blocking pyruvate carboxylase expression triggers ferroptosis and inhibits non-small cell lung cancer progression.Cancer Lett202642508747PubTator, text miningPubMed
Defect-Regulated Hetero-Trimetallic Nanocatalysts Augment Sonocatalytic Dynamic Therapy by Charge Transfer Facilitation and Ferroptosis Cascade Induction.Small202642507989PubTator, text miningPubMed
WGCNA-based identification and experimental validation of TOP2A as a key regulator of ferroptosis in sepsis-associated acute respiratory distress syndrome.Cytotechnology202642502316PubTator, text miningPubMed
Rhubarb extract attenuates periodontitis by modulating an MMP3-associated inflammatory-ferroptotic axis: Integrated multi-omics analysis and experimental validation.Phytomedicine202642501548PubTator, text miningPubMed
Molecular Signatures of Ferroptosis in Sleep Disorders: A Comparative Analysis of GPX4, ACSL4, and TfR1.Mol Neurobiol202642501171PubTator, text miningPubMed
IL-33 as a component of neutrophil extracellular traps mediates contrast-induced acute kidney injury by promoting ferroptosis in tubular epithelial cells.Kidney Int202642498057PubTator, text miningPubMed
Targeting NAE1 suppresses osteoclastogenesis via dual regulation of ferritinophagy and ACSL3-mediated ferroptosis.Autophagy202642495964PubTator, text miningPubMed
Targeting the NR3C1-ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer.Cancer Sci202642492013PubTator, text miningPubMed
MiR-199a-5p aggravates hypoxia/reoxygenation-induced cardiomyocyte ferroptosis by blocking HSPB1-Keap1/Nrf2/ARE signaling.Korean J Physiol Pharmacol202642487470PubTator, text miningPubMed
Identification and Validation of Genes Involved in Immune and Ferroptosis in Polycystic Ovarian Syndrome Using Bioinformatics and Experimental Approach.Biol Proced Online202642482193PubTator, text miningPubMed
PIN1 enhances SUMOylation of YAP1 and inhibits ferroptosis via autophagy-dependent degradation of ACSL4 in cervical cancer.Cell Death Discov202642481442PubTator, text miningPubMed
Dual-function PROTAC suppresses ferroptosis and restores neuronal function via brain-targeted delivery.Cell Chem Biol202642480533PubTator, text miningPubMed
Perfluorobutanesulfonic acid (PFBS) elicits compartment-specific divergent responses in prostate homeostasis: Wnt/β-catenin oncogenic activation in epithelial cells versus mitochondria-mediated ferroptosis susceptibility in stromal cells.
Ecotoxicol Environ Saf202642480139PubTator, text miningPubMed
USP32-mediated stabilization of MAPK12 promotes lung adenocarcinoma progression by inhibiting autophagy-ferroptosis.Commun Biol202642477452PubTator, text miningPubMed
Baicalin alleviates X-ray radiation-induced intestinal injury by inhibiting GPX4 mediated ferroptosis.Sci Rep202642477052PubTator, text miningPubMed
Neural network-enhanced investigation of ferroptosis and druggability in early-onset alzheimer's disease.Metab Brain Dis202642474555PubTator, text miningPubMed
Ferritin Light Chain: A Key Regulator of Nrf2-Dependent Ferroptosis in Oral Squamous Cell Carcinoma.Oral Dis202642473034PubTator, text miningPubMed
Inhibition of PCSK9 protects against myocardial ischemia-reperfusion injury by suppressing ferroptosis via negative regulation of the P65/MMP9 pathway.Sci Rep202642469388PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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