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Gene · 2184

FAH: fumarylacetoacetate hydrolase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FAH: fumarylacetoacetate hydrolase. Genes, record 2184. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2184

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Gene

Symbol
FAH
HGNC
Name
fumarylacetoacetate hydrolase
HGNC
NCBI Gene ID
2184
NCBI Gene
HGNC ID
HGNC:3579
HGNC
Ensembl
ENSG00000103876
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16930Fumarylacetoacetase4198Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21122P16930Espacenet
EP 4650780 A22025-11-191952P16930Espacenet
JP 2025169942 A2025-11-14985P16930Espacenet
JP 2025169942 A2025-11-14986P16930Espacenet
JP 2025169942 A2025-11-14987P16930Espacenet
EP 4641202 A22025-10-294526P16930Espacenet
JP 2025114367 A2025-08-052P16930Espacenet
JP 2025517970 A2025-06-121952P16930Espacenet
KR 1020250017231 A2025-02-044526P16930Espacenet
JP 2024534266 A2024-09-1810P16930Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants958

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFAH papersNewest fiscal year
R01AI107301Genetic Viral and Host Adaptations to Breach Species Barriers of HCV112025
P30DK056338Texas Medical Center Digestive Diseases Center102025
P30CA014051Cancer Center Support (Core) Grant62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025
T32HL092332Training In Cell and Gene Therapy62025
P30CA008748Cancer Center Support Grant52025
R01HL132840Genetic Repair of Familial Hypercholesterolemia52025
P20GM103499South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)42025
P30CA016087Cancer Center Support Grant42025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology42025

1 to 10 of 958Source NIH's project files

See all 958 nih grants

Papers1,282

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A noncanonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer.Sci Adv202642814811PubTator, text miningPubMed
Genetically engineered porcine liver: a new era in transplantation.Int J Surg202642808109PubTator, text miningPubMed
Integrated proteomics and machine learning for identifying candidate serum biomarkers in acute myocardial infarction-complicated cardiogenic shock: a prospective exploratory study.Clin Proteomics202642477545PubTator, text miningPubMed
Disrupting fumarylacetoacetate hydrolase by stratified nanoplatforms orchestrates metabolic-immune reprogramming and prevents post-ablation HCC relapse.Nat Commun202642448675PubTator, text miningPubMed
Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.Cell Rep202642276069PubTator, text miningPubMed
Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle-mediated infection in humanized liver chimeric mouse models.Sci Adv202642213828PubTator, text miningPubMed
Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway.FEBS J202642157621PubTator, text miningPubMed
Rational Design of Small-Molecule Stabilizers of Human Fumarylacetoacetate Hydrolase for the Treatment of Tyrosinemia Type I.J Med Chem202642117404PubTator, text miningPubMed
A Systematic Bioinformatic Analysis of the miRNA Pathway in Inborn Errors of Amino Acid Metabolism Disorders.Mol Syndromol202642038754PubTator, text miningPubMed
Toward Next-Gen Cell Therapy for Pediatric Patients: Neonatal Hepatocytes Tolerate Electroporation-Mediated Gene Editing and Engraft in the Liver.CRISPR J202641928587PubTator, text miningPubMed

1 to 10 of 1,282

See all 1,282 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2184

GET https://conductscience.org/api/genes/v1/2184/patents?page=2