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PTK2B: protein tyrosine kinase 2 beta

1 protein, 62 patents, 2 drugs, 32 trials, 12,123 NIH grants and 37,361 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTK2BHGNC
Nameprotein tyrosine kinase 2 betaHGNC
NCBI Gene ID2185NCBI Gene
HGNC IDHGNC:9612HGNC
EnsemblENSG00000120899NCBI Gene
AliasesCADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14289Protein-tyrosine kinase 2-beta1,00926Ensembl, GeneID, HGNCUniProt

Patents 62

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195990Q14289Espacenet
EP 4641201 A22025-10-295727Q14289Espacenet
JP 2025517969 A2025-06-125727Q14289Espacenet
JP 2025517970 A2025-06-125990Q14289Espacenet
JP 2025062601 A2025-04-1415Q14289Espacenet
JP 2025032204 A2025-03-1134194Q14289Espacenet
JP 2025032204 A2025-03-1134197Q14289Espacenet
EP 4461818 A22024-11-1334194Q14289Espacenet
EP 4461818 A22024-11-1334197Q14289Espacenet
JP 2024123008 A2024-09-107967Q14289Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CONTELTINIBCHEMBL3899477Protein tyrosine kinase 2 beta inhibitorINHIBITORChEMBL
DEFACTINIBCHEMBL3137331Protein tyrosine kinase 2 beta inhibitorINHIBITORChEMBL

Trials 32

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07318324DEFACTINIBPHASE1ClinicalTrials.gov
NCT07126158DEFACTINIBPHASE2ClinicalTrials.gov
NCT06630260DEFACTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06495125DEFACTINIBPHASE2ClinicalTrials.gov
NCT06487221DEFACTINIBPHASE2ClinicalTrials.gov
NCT06394804DEFACTINIBPHASE2ClinicalTrials.gov
NCT06369259DEFACTINIBPHASE2ClinicalTrials.gov
NCT06194929DEFACTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06007924DEFACTINIBPHASE2ClinicalTrials.gov
NCT05798507DEFACTINIBEARLY_PHASE1ClinicalTrials.gov

NIH grants 12123

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1232,025NIH's project files
P30CA008748Cancer Center Support Grant682,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)422,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant242,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award242,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase222,025NIH's project files
P30CA006973Regional Oncology Research Center212,025NIH's project files
P30CA016058Cancer Center Support Grant212,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)212,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support182,025NIH's project files

Papers 37361

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825378PubTator, text miningPubMed
42823563PubTator, text miningPubMed
42822254PubTator, text miningPubMed
42821795PubTator, text miningPubMed
42821792PubTator, text miningPubMed
42821430PubTator, text miningPubMed
42817125PubTator, text miningPubMed
42816979PubTator, text miningPubMed
42816976PubTator, text miningPubMed
42814929PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license