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FAP: fibroblast activation protein alpha

1 protein, 278 patents, 3 drugs, 8 trials, 3,071 NIH grants and 8,028 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFAPHGNC
Namefibroblast activation protein alphaHGNC
NCBI Gene ID2191NCBI Gene
HGNC IDHGNC:3590HGNC
EnsemblENSG00000078098NCBI Gene
AliasesDPPIV, FAPA, FAPalpha, SIMPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q12884Prolyl endopeptidase FAP7604Ensembl, GeneID, HGNCUniProt

Patents 278

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209911 A12026-10-081Q12884Espacenet
WO 2026209914 A12026-10-081Q12884Espacenet
WO 2026190361 A12026-09-1712Q12884Espacenet
WO 2026180469 A22026-09-0335Q12884Espacenet
WO 2026183388 A12026-09-03391Q12884Espacenet
US 12600781 B22026-04-142Q12884Espacenet
JP 2026062901 A2026-04-101Q12884Espacenet
WO 2026069426 A2026-04-0211Q12884Espacenet
JP 2026035703 A2026-03-041Q12884Espacenet
US 12565530 B22026-03-0380Q12884Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
F19 131ICHEMBL2109643Fibroblast activation protein alpha binding agentBINDING AGENTChEMBL
SIBROTUZUMABCHEMBL2108882Fibroblast activation protein alpha binding agentBINDING AGENTChEMBL
SIMLUKAFUSP ALFACHEMBL4298090Fibroblast activation protein alpha binding agentBINDING AGENTChEMBL

Trials 8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03875079SIMLUKAFUSP ALFAPHASE1ClinicalTrials.gov
NCT03386721SIMLUKAFUSP ALFAPHASE22023-02-21ClinicalTrials.gov
NCT03193190SIMLUKAFUSP ALFAPHASE1/PHASE22025-11-21ClinicalTrials.gov
NCT03063762SIMLUKAFUSP ALFAPHASE1ClinicalTrials.gov
NCT02627274SIMLUKAFUSP ALFAPHASE1ClinicalTrials.gov
NCT02209727SIBROTUZUMABPHASE1ClinicalTrials.gov
NCT02198274SIBROTUZUMABPHASE2ClinicalTrials.gov
NCT00004042F19 131IPHASE1ClinicalTrials.gov

NIH grants 3071

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant482,025NIH's project files
P30CA016672Cancer Center Support Grant302,025NIH's project files
P30CA006973Regional Oncology Research Center242,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase182,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant162,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program122,025NIH's project files
P30CA047904Cancer Center Support Grant112,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support102,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant92,025NIH's project files
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer92,025NIH's project files

Papers 8028

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819771PubTator, text miningPubMed
42819034PubTator, text miningPubMed
42818339PubTator, text miningPubMed
42815646PubTator, text miningPubMed
42812195PubTator, text miningPubMed
42797493PubTator, text miningPubMed
42792911PubTator, text miningPubMed
42790205PubTator, text miningPubMed
42783079PubTator, text miningPubMed
42780720PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license