Gene · 2202
EFEMP1: EGF-like fibulin extracellular matrix protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EFEMP1: EGF-like fibulin extracellular matrix protein 1. Genes, record 2202. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2202
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q12805 | EGF-containing fibulin-like extracellular matrix protein 1 | 493 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents109
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44758 | Q12805 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44759 | Q12805 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44760 | Q12805 | Espacenet |
| WO 2025259600 A2 | 2025-12-18 | 89 | Q12805 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7168 | Q12805 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7084 | Q12805 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4565 | Q12805 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4566 | Q12805 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6232 | Q12805 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6232 | Q12805 | Espacenet |
1 to 10 of 109
See all 109 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,569
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EFEMP1 papers | Newest fiscal year |
|---|---|---|---|
| P30EY014104 | P30 Core Grant for Vision Research | 8 | 2025 |
| P30EY030413 | Core Grant for Vision Research | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 5 | 2025 |
| R01EY018213 | Defining Barriers to Gene Therapy | 5 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 4 | 2025 |
| P30EY000331 | Vision Research Core at UCLA | 4 | 2025 |
| R01NS017950 | Precursors of Stroke Incidence and Prognosis | 4 | 2025 |
| ZIAEY000433 | Functional Analysis of Novel Genes in Eye Development and Vision | 4 | 2025 |
1 to 10 of 1,569Source NIH's project files
See all 1,569 nih grantsPapers1,739
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Whole-Transcriptome Analysis of Three Human Cell Lines Stably Infected with Bovine Leukemia Virus (BLV) Reveals Novel Apoptosis-Associated Factors. | Viruses | 2026 | 42797767 | PubTator, text mining | PubMed |
| Correlation analysis of serum PACAP-38, fibulin-3 and TEM1 levels with cardiac function and prognosis in chronic heart failure patients. | J Med Biochem | 2026 | 42780739 | PubTator, text mining | PubMed |
| Connective tissue and genetics in the pathogenesis of rectal prolapse: A scoping review. | Colorectal Dis | 2026 | 42765168 | PubTator, text mining | PubMed |
| Widening the Spectrum of Disease Expression due to Heterozygous Variants in EFEMP1. | JAMA Ophthalmol | 2026 | 42720932 | PubTator, text mining | PubMed |
| The First Case Series of Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy in Türkiye Identified with EFEMP1 Gene Mutation. | Turk J Ophthalmol | 2026 | 42644559 | PubTator, text mining | PubMed |
| Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers. | Respir Res | 2026 | 42634071 | PubTator, text mining | PubMed |
| Development of an antisense oligonucleotide targeting EFEMP1 in models relevant to macular degeneration. | Mol Ther Nucleic Acids | 2026 | 42597498 | PubTator, text mining | PubMed |
| Interactions Between Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 and Tissue Inhibitor of Metalloproteinases-3 and Relevance to Age-Related Macular Degeneration. | Ophthalmol Sci | 2026 | 42569289 | PubTator, text mining | PubMed |
| Multimodal Imaging of Dual BEST1/EFEMP1-Associated Hereditary Macular Disease. | J Clin Med | 2026 | 42513409 | PubTator, text mining | PubMed |
| Restoration of impaired lysosomal function mitigates drusen-like deposit formation and cell death in Malattia Leventinese. | JCI Insight | 2026 | 42484373 | PubTator, text mining | PubMed |
1 to 10 of 1,739
See all 1,739 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2202
GET https://conductscience.org/api/genes/v1/2202/patents?page=2