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Gene · 2203

FBP1: fructose-bisphosphatase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FBP1: fructose-bisphosphatase 1. Genes, record 2203. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2203

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Gene

Symbol
FBP1
HGNC
Name
fructose-bisphosphatase 1
HGNC
NCBI Gene ID
2203
NCBI Gene
HGNC ID
HGNC:3606
HGNC
Ensembl
ENSG00000165140
NCBI Gene
Aliases
FBP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09467Fructose-1,6-bisphosphatase 133851Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21157P09467Espacenet
JP 2026004568 A2026-01-1446720P09467Espacenet
JP 2026004568 A2026-01-1446722P09467Espacenet
EP 4650780 A22025-11-199606P09467Espacenet
EP 4641201 A22025-10-299861P09467Espacenet
EP 4641202 A22025-10-295639P09467Espacenet
WO 2025176691 A12025-08-2810P09467Espacenet
WO 2025142929 A2025-07-031P09467Espacenet
JP 2025517969 A2025-06-129861P09467Espacenet
JP 2025517970 A2025-06-129606P09467Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,213

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFBP1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
R35CA220483Metabolic Influences on Complex Tumor Neighborhoods92025
P30CA008748Cancer Center Support Grant72025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA068485Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P30DK045735Yale Diabetes Research Center42025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)42025
R01DK133448The NRF2-FBP1 crossregulatory loop and the control of healthy and diseased liver metabolism42025

1 to 10 of 1,213Source NIH's project files

See all 1,213 nih grants

Papers2,174

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fructose-1,6-bisphosphatase deficiency: the clinical characteristics, molecular consequences of FBP1 variants, and emerging non-canonical functions of FBP1.Endocr J202642816337PubTator, text miningPubMed
Gene by environment interaction effects on the metabolic subtype of Polycystic Ovary Syndrome in Hispanic Community Health Study/Study of Latinos.Front Genet202642730305PubTator, text miningPubMed
Multi-omics integration uncovers epigenetic control of metabolic reprogramming in triple-negative breast cancer.J Egypt Natl Canc Inst202642684639PubTator, text miningPubMed
Effects of different dietary metabolizable energy levels on growth performance, liver metabolism, and gut microbiota in growing broilers.Poult Sci202642603396PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Fructose-1,6-bisphosphatase as a therapeutic target for type 2 diabetes: from molecular mechanisms to clinical translation.Arch Physiol Biochem202642559717PubTator, text miningPubMed
Integrating Genetic Data and Electronic Medical Records to Reassess Variant Pathogenicity in the Taiwanese Han Population.Genes (Basel)202642510858PubTator, text miningPubMed
Roles of the E3 Ubiquitin Ligase TRIM47 in Inflammation, Organ Injury, and Cancer.FASEB J202642497068PubTator, text miningPubMed
Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.Naunyn Schmiedebergs Arch Pharmacol202642493660PubTator, text miningPubMed
The baseline vitreous proteome in rhegmatogenous retinal detachment: a case-control study of proliferative vitreoretinopathy.Sci Rep202642432032PubTator, text miningPubMed

1 to 10 of 2,174

See all 2,174 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2203

GET https://conductscience.org/api/genes/v1/2203/patents?page=2