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FCGR3A: Fc gamma receptor IIIa

1 protein, 413 patents, 2 drugs, 20 trials, 14,616 NIH grants and 37,403 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFCGR3AHGNC
NameFc gamma receptor IIIaHGNC
NCBI Gene ID2214NCBI Gene
HGNC IDHGNC:3619HGNC
EnsemblENSG00000203747NCBI Gene
AliasesCD16, CD16-II, CD16A, CD16a, FCG3, FCGR3, FCRIIIA, FcGRIIIA, FcgammaRIIIa, IGFR3, IMD20NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08637Low affinity immunoglobulin gamma Fc region receptor III-A25415Ensembl, GeneID, HGNCUniProt

Patents 413

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805397 A12026-09-1693P08637Espacenet
EP 4794715 A12026-08-261175P08637Espacenet
EP 4795154 A12026-08-26103P08637Espacenet
EP 4780853 A12026-07-2960P08637Espacenet
WO 2026128487 A12026-06-18187P08637Espacenet
WO 2026128487 A12026-06-18559P08637Espacenet
EP 4755449 A22026-06-10216P08637Espacenet
EP 4755450 A22026-06-10216P08637Espacenet
EP 4755457 A22026-06-10175P08637Espacenet
JP 2026086473 A2026-05-263P08637Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BEMARITUZUMABCHEMBL4802165Low affinity immunoglobulin gamma Fc region receptor III-A binding agentBINDING AGENTChEMBL
IMGATUZUMABCHEMBL2109389Low affinity immunoglobulin gamma Fc region receptor III-A cross-linking agentCROSS-LINKING AGENTChEMBL

Trials 20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07470840BEMARITUZUMABPHASE2ClinicalTrials.gov
NCT07146919BEMARITUZUMABPHASE1/PHASE2ClinicalTrials.gov
NCT06967987BEMARITUZUMABPHASE2ClinicalTrials.gov
NCT06897579BEMARITUZUMABPHASE2ClinicalTrials.gov
NCT06680622BEMARITUZUMABPHASE2ClinicalTrials.gov
NCT05913115BEMARITUZUMABPHASE1ClinicalTrials.gov
NCT05325866BEMARITUZUMABPHASE1/PHASE2ClinicalTrials.gov
NCT05322577BEMARITUZUMABPHASE1/PHASE2ClinicalTrials.gov
NCT05267470BEMARITUZUMABPHASE12025-03-25ClinicalTrials.gov
NCT05111626BEMARITUZUMABPHASE3ClinicalTrials.gov

NIH grants 14616

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1852,025NIH's project files
P30CA016672Cancer Center Support Grant1342,025NIH's project files
P51OD011132Emory National Primate Research Center872,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies852,025NIH's project files
P01CA111412NK cells, their receptors and cancer therapy832,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro762,025NIH's project files
P30CA016058Cancer Center Support Grant692,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award592,025NIH's project files
P51OD011092Support for National Primate Research Center572,025NIH's project files
P30AI060354Harvard University Center for AIDS Research542,025NIH's project files

Papers 37403

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823801PubTator, text miningPubMed
42823723PubTator, text miningPubMed
42819295PubTator, text miningPubMed
42818364PubTator, text miningPubMed
42818150PubTator, text miningPubMed
42814317PubTator, text miningPubMed
42812615PubTator, text miningPubMed
42811741PubTator, text miningPubMed
42807128PubTator, text miningPubMed
42806711PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license