ConductScience.org, home

Gene · 2230

FDX1: ferredoxin 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. FDX1: ferredoxin 1. Genes, record 2230. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2230

On this page

Gene

Symbol
FDX1
HGNC
Name
ferredoxin 1
HGNC
NCBI Gene ID
2230
NCBI Gene
HGNC ID
HGNC:3638
HGNC
Ensembl
ENSG00000137714
NCBI Gene
Aliases
ADX, FDX, LOH11CR1D
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10109Adrenodoxin, mitochondrial1846Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082924 A2026-05-196P10109Espacenet
US 12545918 B22026-02-108P10109Espacenet
JP 2026004568 A2026-01-1446167P10109Espacenet
EP 4650780 A22025-11-191792P10109Espacenet
JP 2025517970 A2025-06-121792P10109Espacenet
JP 2023515302 A2023-04-137P10109Espacenet
US 11612619 B22023-03-288P10109Espacenet
US 11446398 B22022-09-2031639P10109Espacenet
JP 2022524081 A2022-04-27134610P10109Espacenet
WO 2021174100 A12021-09-026P10109Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants420

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFDX1 papersNewest fiscal year
ZIAHD008814Mammalian iron-sulfur cluster biogenesis62025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b552025
R35GM133375Structural regulation of Class-I and Class-II cytochrome P450 enzymes52025
R35GM122595Mechanisms of Iron-Sulfur Dependent Reactions42025
P30CA093373Cancer Center Support Grant P3032025
R35CA242457Making cancer precision medicine real: bottlenecks and opportunities32025
T32ES007028Training Program in Environmental Toxicology32025
ZIAHD001602Regulation Of Intracellular Iron Metabolism32025
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)22025
P20GM121322Tumor Microenvironment-TME CoBRE22025

1 to 10 of 420Source NIH's project files

See all 420 nih grants

Papers1,417

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SUMOylation of PGAM2 regulates mitochondrial metabolism and cuproptosis-related damage during boar sperm cryoinjury.Theriogenology202742810240PubTator, text miningPubMed
FDX1-short proteoform induces caspase-independent cell death in tumor cells.Cell Death Differ202642816659PubTator, text miningPubMed
Roles of cuproptosis in central nervous system tumors: from molecular mechanisms to therapeutic prospects.Front Cell Dev Biol202642812787PubTator, text miningPubMed
Targeting FDX1 with oridonin triggers cuproptosis and inhibits tumor progression in nasopharyngeal carcinoma.Int J Biochem Cell Biol202642800577PubTator, text miningPubMed
Copper-regulated cell death after spinal cord injury: evidence boundaries for non-coding RNA, epigenetics and cuproptosis.Front Mol Neurosci202642787557PubTator, text miningPubMed
Cuproptosis: a novel mechanism linking placental metabolic stress to trophoblast injury in preeclampsia.Front Endocrinol (Lausanne)202642780476PubTator, text miningPubMed
Elesclomol-mediated cuproptosis overcomes cisplatin resistance by restricting epigenetically activated mitochondrial respiration: Novel therapeutic insights into cisplatin-elesclomol combination therapy.
Acta Pharm Sin B202642764935PubTator, text miningPubMed
SF1 regulates the transcription of FDX1 to promote cuproptosis in pediatric sepsis-related acute lung injury by interacting with cJUN.Biol Direct202642764381PubTator, text miningPubMed
SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway.Kaohsiung J Med Sci202642757550PubTator, text miningPubMed
Cuproptosis in cerebrovascular diseases: Mechanisms and advances in targeted therapeutic strategies.Brain Res Bull202642754178PubTator, text miningPubMed

1 to 10 of 1,417

See all 1,417 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2230

GET https://conductscience.org/api/genes/v1/2230/patents?page=2