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Gene · 2235

FECH: ferrochelatase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FECH: ferrochelatase. Genes, record 2235. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2235

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Gene

Symbol
FECH
HGNC
Name
ferrochelatase
HGNC
NCBI Gene ID
2235
NCBI Gene
HGNC ID
HGNC:3647
HGNC
Ensembl
ENSG00000066926
NCBI Gene
Aliases
EPP, EPP1, FCE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22830Ferrochelatase, mitochondrial42325Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11503P22830Espacenet
JP 2026004568 A2026-01-1446185P22830Espacenet
EP 4650780 A22025-11-192010P22830Espacenet
JP 2025517970 A2025-06-122010P22830Espacenet
JP 2025081326 A2025-05-2741P22830Espacenet
JP 2025013347 A2025-01-24151P22830Espacenet
JP 2025013347 A2025-01-24503P22830Espacenet
US 12201675 B22025-01-21151P22830Espacenet
JP 2025003953 A2025-01-14150P22830Espacenet
EP 4406585 A22024-07-31151P22830Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,110

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFECH papersNewest fiscal year
U54DK110858Center for Iron & Heme Disorders at the University of Utah152025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis132025
R01EY025641Ferrochelatase as a mediator of ocular angiogenesis102025
ZIAHD001602Regulation Of Intracellular Iron Metabolism102025
P30DK034987Center for Gastrointestinal Biology and Disease82025
R01DK074797Inter-organ signaling in heme metabolism and organismal homeostasis.62025
P30CA023108Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
R35GM131701Mitochondrial Fidelity and Homeostasis42025

1 to 10 of 1,110Source NIH's project files

See all 1,110 nih grants

Papers1,987

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A transferrin receptor-targeted liposome for iron metabolism regulation-augmented photodynamic therapy in glioblastoma.Bioact Mater202742780992PubTator, text miningPubMed
Griseofulvin as a dual-action agent against glioblastoma: anti-tumor effect and enhancement of 5-ALA photodynamic diagnosis in stem-like cells.Cancer Treat Res Commun202642710153PubTator, text miningPubMed
Acute on chronic liver failure in erythropoietic protoporphyria: A case report and review of the literature.Hepatol Forum202642602091PubTator, text miningPubMed
FECH, a novel metabolic target influencing CAR T-cell phenotype and function.Biomark Res202642587334PubTator, text miningPubMed
Design, synthesis, and evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates for enhanced photodynamic therapy in triple-negative breast cancer.Bioorg Med Chem Lett202642586492PubTator, text miningPubMed
Results from the first clinical trial of bitopertin for steroid-relapsed/refractory Diamond-Blackfan anemia.Blood Red Cells Iron202642583025PubTator, text miningPubMed
Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs.Exp Hematol Oncol202642547896PubTator, text miningPubMed
Cascade Amplification of Photoimmunotherapy via Mitochondrial Dual-Ion Interference in a Bimetallic-Organic Framework.Small202642535344PubTator, text miningPubMed
AI-driven structure- and ligand-based discovery of novel Ferrochelatase inhibitors from heterocyclic libraries.J Mol Graph Model202642520493PubTator, text miningPubMed
Alectinib combined with 5-aminolevulinic acid-based photodynamic therapy promotes apoptosis in endometrial cancer cells by targeting ferrochelatase.Front Oncol202642453882PubTator, text miningPubMed

1 to 10 of 1,987

See all 1,987 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2235

GET https://conductscience.org/api/genes/v1/2235/patents?page=2