Gene · 2237
FEN1: flap structure-specific endonuclease 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FEN1: flap structure-specific endonuclease 1. Genes, record 2237. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2237
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P39748 | Flap endonuclease 1 | 380 | 28 | Ensembl, GeneID, HGNC |
Source UniProt
Patents171
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12624353 B2 | 2026-05-12 | 198 | P39748 | Espacenet |
| US 12624353 B2 | 2026-05-12 | 7 | P39748 | Espacenet |
| US 12624354 B2 | 2026-05-12 | 198 | P39748 | Espacenet |
| US 12624354 B2 | 2026-05-12 | 7 | P39748 | Espacenet |
| JP 2026062659 A | 2026-04-10 | 7 | P39748 | Espacenet |
| JP 2026062659 A | 2026-04-10 | 198 | P39748 | Espacenet |
| EP 4709870 A1 | 2026-03-18 | 212 | P39748 | Espacenet |
| US 12570972 B2 | 2026-03-10 | 198 | P39748 | Espacenet |
| US 12570972 B2 | 2026-03-10 | 7 | P39748 | Espacenet |
| US 12509680 B2 | 2025-12-30 | 198 | P39748 | Espacenet |
1 to 10 of 171
See all 171 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,316
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FEN1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 68 | 2025 |
| R01CA073764 | FEN1-mediated Okazaki fragment maturation and its deficiency in cancer | 48 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 25 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 25 | 2025 |
| ZIAAG000726 | Function of RecQ helicases in genome stability | 21 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 20 | 2025 |
| ZIAAG000752 | Model Genetic Systems to Study DNA Repair | 14 | 2025 |
| ZIAAG000753 | Fanconi Anemia Pathway | 13 | 2025 |
| R35CA220430 | Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC) | 12 | 2025 |
| R50CA211397 | Functional Analysis of Structure Specific Nucleases in Genome Stability and Cancers | 12 | 2025 |
1 to 10 of 2,316Source NIH's project files
See all 2,316 nih grantsPapers3,948
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exponential strand displacement amplification-assisted microchip electrophoresis for rapid and simultaneous detection of base excision repair enzymes. | J Chromatogr A | 2026 | 42815109 | PubTator, text mining | PubMed |
| Dual-Driver Myeloproliferative Neoplasm: Concurrent p190 BCR::ABL1 CML and JAK2 V617F Mutation: A Case Report and Literature Review. | Case Rep Hematol | 2026 | 42781115 | PubTator, text mining | PubMed |
| Integrated Genetic Screening Identifies FEN1 as a Selective Vulnerability and Temozolomide Resistance Mediator in Glioblastoma Stem Cells. | Cancer Res Commun | 2026 | 42770249 | PubTator, text mining | PubMed |
| Increased NETosis in Patients With Heart Failure Is Associated With Macrophage Activation Towards a Proinflammatory Phenotype. | J Cell Mol Med | 2026 | 42725813 | PubTator, text mining | PubMed |
| In vitro reconstitution of chromatin replication recapitulates symmetric histone recycling. | Nat Commun | 2026 | 42711322 | PubTator, text mining | PubMed |
| Low-Potential Electrochemiluminescence of Carbon Dots Enabled by Co-Mn Bimetallic Atoms for Bioanalysis. | Anal Chem | 2026 | 42689601 | PubTator, text mining | PubMed |
| Mitochondria-Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA-Driven Inflammation at the Source. | Adv Sci (Weinh) | 2026 | 42681754 | PubTator, text mining | PubMed |
| DNA damage response genes in lung cancer: Diagnostic, prognostic, and therapeutic implications - A narrative review. | Crit Rev Oncol Hematol | 2026 | 42603641 | PubTator, text mining | PubMed |
| A systems biology approach to find representative genes in Acute Myeloid Leukemia. | PLoS One | 2026 | 42507679 | PubTator, text mining | PubMed |
| Intranasal drop of multiplex RNA therapy for SARS-CoV-2 infections: baicalein-enhanced FEN1 nuclease cleaving as a virus buster. | Emerg Microbes Infect | 2026 | 42504705 | PubTator, text mining | PubMed |
1 to 10 of 3,948
See all 3,948 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2237
GET https://conductscience.org/api/genes/v1/2237/patents?page=2