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FGB: fibrinogen beta chain

1 protein, 156 patents, 6 drugs, 40 trials, 16,391 NIH grants and 95,087 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGBHGNC
Namefibrinogen beta chainHGNC
NCBI Gene ID2244NCBI Gene
HGNC IDHGNC:3662HGNC
EnsemblENSG00000171564NCBI Gene
AliasesHEL-S-78pNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P02675Fibrinogen beta chain49141Ensembl, GeneID, HGNCUniProt

Patents 156

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026090253 A2026-06-022P02675Espacenet
WO 2025249462 A2025-12-043P02675Espacenet
EP 4650780 A22025-11-194396P02675Espacenet
JP 2025169942 A2025-11-14974P02675Espacenet
EP 4640849 A22025-10-29578P02675Espacenet
EP 4641201 A22025-10-293939P02675Espacenet
JP 2025147176 A2025-10-065269P02675Espacenet
JP 2025529142 A2025-09-046367P02675Espacenet
US 12371689 B22025-07-296367P02675Espacenet
JP 2025519280 A2025-06-253P02675Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFIMEPRASECHEMBL2108893Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
ANCRODCHEMBL2108481Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
BICIROMAB BRALLOBARBITALCHEMBL2109283Fibrinogen beta chain binding agentBINDING AGENTChEMBL
FIBRINOGEN, HUMANCHEMBL2109072Fibrinogen exogenous proteinEXOGENOUS PROTEINChEMBL
FIBRINOLYSIN, HUMANCHEMBL1201505Fibrinogen inhibitorINHIBITORChEMBL
PLASMINOGENCHEMBL2108131Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials 40

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07425600FIBRINOGEN, HUMANClinicalTrials.gov
NCT06617897FIBRINOGEN, HUMANPHASE3ClinicalTrials.gov
NCT06381661PLASMINOGENPHASE2ClinicalTrials.gov
NCT05717335FIBRINOGEN, HUMANClinicalTrials.gov
NCT04636268FIBRINOGEN, HUMANPHASE3ClinicalTrials.gov
NCT04586062PLASMINOGENClinicalTrials.gov
NCT04275232PLASMINOGENPHASE3ClinicalTrials.gov
NCT03932240FIBRINOGEN, HUMANPHASE32023-03-20ClinicalTrials.gov
NCT03784794FIBRINOGEN, HUMANClinicalTrials.gov
NCT03642691PLASMINOGENClinicalTrials.gov

NIH grants 16391

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32GM008315Mechanisms of Trauma-Induced Coagulopathy782,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award672,025NIH's project files
P30CA008748Cancer Center Support Grant612,025NIH's project files
U19AG051426Integrative Pathways to Health and Illness512,025NIH's project files
P30CA016672Cancer Center Support Grant472,025NIH's project files
R01AG017644English Longitudinal Study of Ageing - Renewal 2024472,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI442,025NIH's project files
R01HL049413Structural basis of prothrombin activation412,025NIH's project files
R01HL056051Fibrin(ogen) Structure and Interactions342,025NIH's project files
P30DK017047Diabetes Research Center302,025NIH's project files

Papers 95087

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826477PubTator, text miningPubMed
42826329PubTator, text miningPubMed
42825136PubTator, text miningPubMed
42823549PubTator, text miningPubMed
42822085PubTator, text miningPubMed
42819136PubTator, text miningPubMed
42818736PubTator, text miningPubMed
42817842PubTator, text miningPubMed
42810911PubTator, text miningPubMed
42808109PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license