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FGF1: fibroblast growth factor 1

1 protein, 412 patents, 6 drugs, 45 trials, 3,223 NIH grants and 6,200 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGF1HGNC
Namefibroblast growth factor 1HGNC
NCBI Gene ID2246NCBI Gene
HGNC IDHGNC:3665HGNC
EnsemblENSG00000113578NCBI Gene
AliasesAFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05230Fibroblast growth factor 115596Ensembl, GeneID, HGNCUniProt

Patents 412

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11209P05230Espacenet
EP 4705273 A22026-03-11555P05230Espacenet
JP 2025013347 A2025-01-24106P05230Espacenet
JP 2025013347 A2025-01-24209P05230Espacenet
JP 2025013347 A2025-01-24555P05230Espacenet
US 12201675 B22025-01-21106P05230Espacenet
JP 2025003953 A2025-01-14106P05230Espacenet
KR 1020240162163 A2024-11-14106P05230Espacenet
JP 2024123008 A2024-09-106210P05230Espacenet
JP 2024123008 A2024-09-106211P05230Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALDAFERMINCHEMBL4298055FGF1/KLB activatorACTIVATORChEMBL
FAZPILODEMABCHEMBL4297909FGF1/KLB agonistAGONISTChEMBL
MUPARFOSTATCHEMBL4297163Acidic fibroblast growth factor inhibitorINHIBITORChEMBL
PEGBELFERMINCHEMBL4297578FGF1/KLB agonistAGONISTChEMBL
SURAMINCHEMBL265502Acidic fibroblast growth factor inhibitorINHIBITORChEMBL
SURAMIN HEXASODIUMCHEMBL413376Acidic fibroblast growth factor inhibitorINHIBITORChEMBL

Trials 45

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06866275SURAMINPHASE2ClinicalTrials.gov
NCT06866275SURAMIN HEXASODIUMPHASE2ClinicalTrials.gov
NCT06654726ALDAFERMINPHASE2/PHASE3ClinicalTrials.gov
NCT06058962SURAMINPHASE2ClinicalTrials.gov
NCT05130047ALDAFERMINPHASE22023-10-12ClinicalTrials.gov
NCT04210245ALDAFERMINPHASE22025-03-26ClinicalTrials.gov
NCT04179630ALDAFERMINPHASE1ClinicalTrials.gov
NCT04171765FAZPILODEMABPHASE22024-04-16ClinicalTrials.gov
NCT03912532ALDAFERMINPHASE22025-07-03ClinicalTrials.gov
NCT03486912PEGBELFERMINPHASE22022-10-13ClinicalTrials.gov

NIH grants 3223

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant262,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)122,025NIH's project files
P30CA093373Cancer Center Support Grant P30102,025NIH's project files
P30DK035816Nutrition Obesity Research Center92,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant82,025NIH's project files
P30MH062512HIV Neurobehavioral Research Center82,025NIH's project files
P30CA008748Cancer Center Support Grant72,025NIH's project files
P30CA013148Comprehensive Cancer Center Support Grant72,025NIH's project files
P30DK017047Diabetes Research Center72,025NIH's project files
R01DK083042Divergent Mechanisms Underlying Anorexic and Antidiabetic Actions of FGF1 in the Brain72,025NIH's project files

Papers 6200

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822673PubTator, text miningPubMed
42743414PubTator, text miningPubMed
42701552PubTator, text miningPubMed
42612390PubTator, text miningPubMed
42589503PubTator, text miningPubMed
42575395PubTator, text miningPubMed
42569572PubTator, text miningPubMed
42511911PubTator, text miningPubMed
42486092PubTator, text miningPubMed
42473145PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license