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Gene · 2253

FGF8: fibroblast growth factor 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FGF8: fibroblast growth factor 8. Genes, record 2253. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2253

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Gene

Symbol
FGF8
HGNC
Name
fibroblast growth factor 8
HGNC
NCBI Gene ID
2253
NCBI Gene
HGNC ID
HGNC:3686
HGNC
Ensembl
ENSG00000107831
NCBI Gene
Aliases
AIGF, FGF-8, HBGF-8, HH6, KAL6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55075Fibroblast growth factor 82331Ensembl, GeneID, HGNC

Source UniProt

Patents75

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11215P55075Espacenet
EP 4650780 A22025-11-196494P55075Espacenet
JP 2025147176 A2025-10-065293P55075Espacenet
JP 2025529142 A2025-09-046379P55075Espacenet
EP 4606428 A22025-08-2744P55075Espacenet
US 12371689 B22025-07-296379P55075Espacenet
JP 2025517970 A2025-06-126494P55075Espacenet
JP 2025028160 A2025-02-285293P55075Espacenet
JP 2025013347 A2025-01-24215P55075Espacenet
KR 1020250010750 A2025-01-215293P55075Espacenet

1 to 10 of 75

See all 75 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,059

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFGF8 papersNewest fiscal year
P30CA008748Cancer Center Support Grant222025
R01DE019638The role of continuous phenotypic variation in structural defects of the face92025
P30CA016672Cancer Center Support Grant62025
ZIABC010338The Role of Fgf Signaling in Vertebrate Development62025
R35NS116843Continuous Neurogenesis in the Mammalian Hippocampus52025
P30CA013330Cancer Center Support Grant42025
P30CA014195Cancer Center Support Grant (CCSG)42025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P51OD011106Wisconsin National Primate Research Center Support42025

1 to 10 of 2,059Source NIH's project files

See all 2,059 nih grants

Papers3,175

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
FGF/FGFR signaling in hepatocellular carcinoma: From molecular mechanisms to biomarker-guided therapy.Cancer Treat Res Commun202642753578PubTator, text miningPubMed
A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity.J Biochem Mol Toxicol202642573050PubTator, text miningPubMed
Cellular Logistics and Synaptic Vesicle Vulnerability in Major Depressive Disorder and Amyotrophic Lateral Sclerosis Comorbidity: Insights From Nicotinamide Mononucleotide Rescue and Transcriptome-Wide Association Study Integration.
Cureus202642529685PubTator, text miningPubMed
Genome-wide assessment of rare protein-coding variants identifies associations with non-syndromic cleft lip/palate.Eur J Hum Genet202642477406PubTator, text miningPubMed
CRISPR activation of DLX5 drives neural progenitors to the GnRH cell fate.J Mol Endocrinol202642454502PubTator, text miningPubMed
FOXI3 promotes migration and proliferation in prostate cancer bone metastases, modulated by FGF8.Front Oncol202642394686PubTator, text miningPubMed
Combined HS6ST1 and HS6ST2 loss disrupts the formation and migration of gonadotropin-releasing hormone neurons.Development202642358159PubTator, text miningPubMed
FGF8-mediated TRIM16 regulation promotes K48-linked ubiquitination and degradation of RIG-I to facilitate Influenza a virus immune evasion.Virulence202642171628PubTator, text miningPubMed
Identification of two novel PATL2 variants and transcriptome sequencing reveals their role in oocyte maturation.J Ovarian Res202642063164PubTator, text miningPubMed
FGF8 accelerates osteoarthritic chondrocyte hypertrophy by JunB-mediated cytokine perturbation.Life Sci202641990914PubTator, text miningPubMed

1 to 10 of 3,175

See all 3,175 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2253

GET https://conductscience.org/api/genes/v1/2253/patents?page=2