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Gene · 226

ALDOA: aldolase, fructose-bisphosphate A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALDOA: aldolase, fructose-bisphosphate A. Genes, record 226. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/226

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Gene

Symbol
ALDOA
HGNC
Name
aldolase, fructose-bisphosphate A
HGNC
NCBI Gene ID
226
NCBI Gene
HGNC ID
HGNC:414
HGNC
Ensembl
ENSG00000149925
NCBI Gene
Aliases
ALDA, GSD12, HEL-S-87p
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04075Fructose-bisphosphate aldolase A3648Ensembl, GeneID, HGNC

Source UniProt

Patents217

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913041P04075Espacenet
JP 2025169942 A2025-11-14787P04075Espacenet
JP 2025169942 A2025-11-14788P04075Espacenet
JP 2025169942 A2025-11-14790P04075Espacenet
JP 2025169942 A2025-11-14791P04075Espacenet
JP 2025169942 A2025-11-14793P04075Espacenet
JP 2025157475 A2025-10-1563P04075Espacenet
JP 2025147176 A2025-10-06707P04075Espacenet
JP 2025147176 A2025-10-06708P04075Espacenet
JP 2025147176 A2025-10-06709P04075Espacenet

1 to 10 of 217

See all 217 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,951

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALDOA papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant102025
P30CA015704Cancer Center Support Grant52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA006973Regional Oncology Research Center42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study32025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE32025
P30AG066444Alzheimer's Disease Research Center32025

1 to 10 of 1,951Source NIH's project files

See all 1,951 nih grants

Papers2,824

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The PKMYT1-ALDOA axis drives chemoresistance in cholangiocarcinoma by enhancing glycolysis and MRE11 lactylation.Proc Natl Acad Sci U S A202642809391PubTator, text miningPubMed
Peritoneal Fluid-Derived Small Extracellular Vesicle Proteins as Potential Biomarkers for Endometriosis: A Case-Control Study.BJOG202642786124PubTator, text miningPubMed
KDM6B inhibition modulates monocyte activation and alleviates IMQ-induced psoriasis-like skin inflammation.Cell Commun Signal202642732058PubTator, text miningPubMed
The KAT2/HDACⅡa-PGK-ALDO axis constitutes a dual degradation inhibition cascade links energy stress to glycolytic amplification.Proc Natl Acad Sci U S A202642611992PubTator, text miningPubMed
The role of mitochondrial energy metabolism in drug resistance and prognosis of lung adenocarcinoma: a multi-omics and machine learning strategy for predictive and personalized therapy.Front Med (Lausanne)202642601962PubTator, text miningPubMed
Metabolic reprogramming is associated with symptomatic COVID-19: a serum proteomics and causal inference study identifying ALDOB and glycerol as candidate metabolic correlates.Front Microbiol202642568671PubTator, text miningPubMed
Epitranscriptomic Regulation of ALDOA by SHMT2-Mediated m6A Modification Drives Gastric Cancer Malignancy.Mol Carcinog202642541491PubTator, text miningPubMed
Label-free detection of glioma radioresistance using exosomal SERS spectra and machine learning.Biosens Bioelectron202642497545PubTator, text miningPubMed
Integrative analysis identifies ALDOA and PGK1 as prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma.Discov Oncol202642463560PubTator, text miningPubMed
The ubiquitin ligase LONRF2 inhibits glycolysis and malignant phenotypes in endometrial cancer through aldolase a degradation.J Biol Chem202642442502PubTator, text miningPubMed

1 to 10 of 2,824

See all 2,824 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/226

GET https://conductscience.org/api/genes/v1/226/patents?page=2