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FGFR3: fibroblast growth factor receptor 3

1 protein, 253 patents, 26 drugs, 615 trials, 4,299 NIH grants and 12,196 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGFR3HGNC
Namefibroblast growth factor receptor 3HGNC
NCBI Gene ID2261NCBI Gene
HGNC IDHGNC:3690HGNC
EnsemblENSG00000068078NCBI Gene
AliasesACH, CD333, CEK2, HSFGFR3EX, JTK4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P22607Fibroblast growth factor receptor 380616Ensembl, GeneID, HGNCUniProt

Patents 253

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4820553 A12026-10-142P22607Espacenet
EP 4650780 A22025-11-1913921P22607Espacenet
EP 4641201 A22025-10-2916148P22607Espacenet
JP 2025163070 A2025-10-28383P22607Espacenet
JP 2025147176 A2025-10-065348P22607Espacenet
JP 2025529142 A2025-09-041572P22607Espacenet
JP 2025529142 A2025-09-046385P22607Espacenet
US 12378312 B22025-08-05313P22607Espacenet
US 12371689 B22025-07-291572P22607Espacenet
US 12371689 B22025-07-296385P22607Espacenet

Drugs 26

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BRIVANIBCHEMBL377300Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIB ALANINATECHEMBL270995Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
CP-459632CHEMBL3545300Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
DERAZANTINIBCHEMBL4297187Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
DOVITINIBCHEMBL522892Fibroblast growth factor receptor 3 inhibitorINHIBITORChEMBL
E-7090CHEMBL3686884Fibroblast growth factor receptor 3 inhibitorINHIBITORChEMBL
ENMD-2076CHEMBL482968Fibroblast growth factor receptor 3 inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
ERDAFITINIBCHEMBL3545376Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
FEXAGRATINIBCHEMBL3348846Fibroblast growth factor receptor inhibitorINHIBITORChEMBL

Trials 615

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07594548FUTIBATINIBPHASE1ClinicalTrials.gov
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07491523NINTEDANIBClinicalTrials.gov
NCT07444619PAZOPANIBPHASE1ClinicalTrials.gov
NCT07434843PEMIGATINIBPHASE2ClinicalTrials.gov
NCT07393373INFIGRATINIBPHASE2ClinicalTrials.gov
NCT07344558NINTEDANIBPHASE1ClinicalTrials.gov
NCT07194382NINTEDANIBPHASE2ClinicalTrials.gov
NCT07174492MASITINIBPHASE3ClinicalTrials.gov
NCT07169279INFIGRATINIBPHASE2ClinicalTrials.gov

NIH grants 4299

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1652,025NIH's project files
P30CA016672Cancer Center Support Grant1472,025NIH's project files
P50CA186781Mayo Clinic Multiple Myeloma SPORE332,025NIH's project files
P30CA006973Regional Oncology Research Center272,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant262,025NIH's project files
P30CA086862Cancer Center Support Grant172,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award172,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant162,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
P30CA068485Cancer Center Support Grant132,025NIH's project files

Papers 12196

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824983PubTator, text miningPubMed
42824949PubTator, text miningPubMed
42820048PubTator, text miningPubMed
42819076PubTator, text miningPubMed
42815410PubTator, text miningPubMed
42807154PubTator, text miningPubMed
42795890PubTator, text miningPubMed
42794513PubTator, text miningPubMed
42792838PubTator, text miningPubMed
42784129PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license