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FGFR2: fibroblast growth factor receptor 2

1 protein, 224 patents, 28 drugs, 609 trials, 5,646 NIH grants and 13,465 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGFR2HGNC
Namefibroblast growth factor receptor 2HGNC
NCBI Gene ID2263NCBI Gene
HGNC IDHGNC:3689HGNC
EnsemblENSG00000066468NCBI Gene
AliasesBBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21802Fibroblast growth factor receptor 282163Ensembl, GeneID, HGNCUniProt

Patents 224

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026508860 A2026-03-131P21802Espacenet
JP 2026004568 A2026-01-1446251P21802Espacenet
WO 2025247951 A12025-12-0440P21802Espacenet
EP 4650780 A22025-11-197553P21802Espacenet
EP 4641201 A22025-10-297564P21802Espacenet
EP 4641202 A22025-10-29410P21802Espacenet
EP 4641203 A22025-10-29218P21802Espacenet
JP 2025163070 A2025-10-28382P21802Espacenet
JP 2025147176 A2025-10-065332P21802Espacenet
JP 2025529142 A2025-09-041571P21802Espacenet

Drugs 28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APRUTUMAB IXADOTINCHEMBL4650293Fibroblast growth factor receptor 2 binding agentBINDING AGENTChEMBL
BEMARITUZUMABCHEMBL4802165Fibroblast growth factor receptor 2 inhibitorINHIBITORChEMBL
BRIVANIBCHEMBL377300Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIB ALANINATECHEMBL270995Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
CP-459632CHEMBL3545300Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
DERAZANTINIBCHEMBL4297187Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
E-7090CHEMBL3686884Fibroblast growth factor receptor 2 inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
ERDAFITINIBCHEMBL3545376Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
FEXAGRATINIBCHEMBL3348846Fibroblast growth factor receptor inhibitorINHIBITORChEMBL

Trials 609

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07594548FUTIBATINIBPHASE1ClinicalTrials.gov
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07491523NINTEDANIBClinicalTrials.gov
NCT07470840BEMARITUZUMABPHASE2ClinicalTrials.gov

NIH grants 5646

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1612,025NIH's project files
P30CA016672Cancer Center Support Grant1382,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE412,025NIH's project files
P30CA068485Cancer Center Support Grant332,025NIH's project files
P30CA016058Cancer Center Support Grant282,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant252,025NIH's project files
P30CA016086Cancer Center Support Grant232,025NIH's project files
P50CA058223SPORE in Breast Cancer232,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant222,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award212,025NIH's project files

Papers 13465

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822735PubTator, text miningPubMed
42811645PubTator, text miningPubMed
42809687PubTator, text miningPubMed
42797465PubTator, text miningPubMed
42782905PubTator, text miningPubMed
42782842PubTator, text miningPubMed
42777170PubTator, text miningPubMed
42764109PubTator, text miningPubMed
42752674PubTator, text miningPubMed
42750272PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license