ConductScience.org, home

Library / Genes

FGFR4: fibroblast growth factor receptor 4

1 protein, 154 patents, 18 drugs, 275 trials, 3,212 NIH grants and 6,315 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGFR4HGNC
Namefibroblast growth factor receptor 4HGNC
NCBI Gene ID2264NCBI Gene
HGNC IDHGNC:3691HGNC
EnsemblENSG00000160867NCBI Gene
AliasesCD334, JTK2, TKFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P22455Fibroblast growth factor receptor 480252Ensembl, GeneID, HGNCUniProt

Patents 154

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193499P22455Espacenet
EP 4640849 A22025-10-29440P22455Espacenet
EP 4641201 A22025-10-293083P22455Espacenet
JP 2025163070 A2025-10-28384P22455Espacenet
JP 2025147176 A2025-10-065358P22455Espacenet
JP 2025147176 A2025-10-065361P22455Espacenet
JP 2025529142 A2025-09-041573P22455Espacenet
JP 2025529142 A2025-09-046386P22455Espacenet
US 12378312 B22025-08-05315P22455Espacenet
US 12371689 B22025-07-291573P22455Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALDAFERMINCHEMBL4298055FGFR4-KLB activatorACTIVATORChEMBL
BRIVANIBCHEMBL377300Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
BRIVANIB ALANINATECHEMBL270995Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
CP-459632CHEMBL3545300Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
DERAZANTINIBCHEMBL4297187Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
ERDAFITINIBCHEMBL3545376Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
FEXAGRATINIBCHEMBL3348846Fibroblast growth factor receptor inhibitorINHIBITORChEMBL
FGF401CHEMBL3908979Fibroblast growth factor receptor 4 inhibitorINHIBITORChEMBL
FUTIBATINIBCHEMBL3701238Fibroblast growth factor receptor inhibitorINHIBITORChEMBL

Trials 275

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07594548FUTIBATINIBPHASE1ClinicalTrials.gov
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07491523NINTEDANIBClinicalTrials.gov
NCT07393373INFIGRATINIBPHASE2ClinicalTrials.gov
NCT07344558NINTEDANIBPHASE1ClinicalTrials.gov
NCT07194382NINTEDANIBPHASE2ClinicalTrials.gov
NCT07169279INFIGRATINIBPHASE2ClinicalTrials.gov
NCT07162961NINTEDANIBPHASE3ClinicalTrials.gov
NCT06926491INFIGRATINIBPHASE3ClinicalTrials.gov
NCT06919965ERDAFITINIBPHASE3ClinicalTrials.gov

NIH grants 3212

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant652,025NIH's project files
P30CA008748Cancer Center Support Grant452,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant172,025NIH's project files
ZIABC011002Bioinformatics, Machine Learning, Systems Biology of Cancers142,025NIH's project files
P30CA047904Cancer Center Support Grant122,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)102,025NIH's project files
P30CA068485Cancer Center Support Grant102,025NIH's project files
ZIABC010999Targeting FGFR4, RAS, and PAX3-FOXO1 gene in Rhabdomyosarcoma102,025NIH's project files
P30CA006973Regional Oncology Research Center92,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant92,025NIH's project files

Papers 6315

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825310PubTator, text miningPubMed
42822673PubTator, text miningPubMed
42799816PubTator, text miningPubMed
42783456PubTator, text miningPubMed
42753578PubTator, text miningPubMed
42743606PubTator, text miningPubMed
42737619PubTator, text miningPubMed
42731718PubTator, text miningPubMed
42724722PubTator, text miningPubMed
42716826PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license