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Gene · 2268

FGR: FGR proto-oncogene, Src family tyrosine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FGR: FGR proto-oncogene, Src family tyrosine kinase. Genes, record 2268. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2268

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Gene

Symbol
FGR
HGNC
Name
FGR proto-oncogene, Src family tyrosine kinase
HGNC
NCBI Gene ID
2268
NCBI Gene
HGNC ID
HGNC:3697
HGNC
Ensembl
ENSG00000000938
NCBI Gene
Aliases
SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09769Tyrosine-protein kinase Fgr5293Ensembl, GeneID, HGNC

Source UniProt

Patents83

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-295610P09769Espacenet
KR 1020250017231 A2025-02-045610P09769Espacenet
JP 2024123008 A2024-09-106318P09769Espacenet
JP 2024123008 A2024-09-106319P09769Espacenet
JP 2024123008 A2024-09-106320P09769Espacenet
JP 2024123008 A2024-09-106321P09769Espacenet
US 11884978 B22024-01-30508P09769Espacenet
US 11685954 B22023-06-27244P09769Espacenet
US 11685954 B22023-06-27245P09769Espacenet
US 11685954 B22023-06-27246P09769Espacenet

1 to 10 of 83

See all 83 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989SRC inhibitorINHIBITORChEMBL
XL-228CHEMBL3545085SRC inhibitorINHIBITORChEMBL

Trials225

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06055621DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT05993949DASATINIB ANHYDROUSPHASE1ClinicalTrials.gov
NCT05751044DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05559008DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05432518DASATINIB ANHYDROUSEARLY_PHASE1ClinicalTrials.gov
NCT05422885DASATINIB ANHYDROUSPHASE1/PHASE22025-03-17ClinicalTrials.gov

1 to 10 of 225

See all 225 trials

NIH grants1,408

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFGR papersNewest fiscal year
P30CA016672Cancer Center Support Grant232025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA008748Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
R01GM086858New Molecular Probes For Protein Kinases52025
P30CA014520UW Comprehensive Cancer Center Support42025
P30CA068485Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE32025
P30CA036727Buffett Cancer Center Support Grant32025

1 to 10 of 1,408Source NIH's project files

See all 1,408 nih grants

Papers1,862

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environ Epigenet202642698993PubTator, text miningPubMed
Apigenin restores macrophage homeostasis and angiogenesis via Fgr/IL10 axis in recurrent spontaneous abortion.Biochem Pharmacol202642462890PubTator, text miningPubMed
Exploration of the mechanism of Xinjiang Rosa laxa Retz.Fruit extract on IgA nephropathy by bioinformatics and machine learning methods.Bioresour Bioprocess202642307669PubTator, text miningPubMed
Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftment.Cell Rep202642301812PubTator, text miningPubMed
Proteomics in myelodysplastic syndromes: towards novel prognostic and diagnostic biomarkers.Biochem Med (Zagreb)202642299353PubTator, text miningPubMed
Elevated FGR protein expression identifies a high-risk subset of diffuse large B-cell lymphoma and a potential therapeutic target.Front Oncol202642078811PubTator, text miningPubMed
Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies.Sci Adv202641920990PubTator, text miningPubMed
Twin-Specific Growth Charts Improve Placental FGR Risk Stratification in Dichorionic Twins: A Commentary.BJOG202641918403PubTator, text miningPubMed
Complementary multi-omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes.Animal Model Exp Med202641915478PubTator, text miningPubMed
Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine202641849830PubTator, text miningPubMed

1 to 10 of 1,862

See all 1,862 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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