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Gene · 2271

FH: fumarate hydratase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FH: fumarate hydratase. Genes, record 2271. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2271

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Gene

Symbol
FH
HGNC
Name
fumarate hydratase
HGNC
NCBI Gene ID
2271
NCBI Gene
HGNC ID
HGNC:3700
HGNC
Ensembl
ENSG00000091483
NCBI Gene
Aliases
FMRD, FUM, HLRCC, HsFH, LRCC, MCL, MCUL1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07954Fumarate hydratase, mitochondrial5108Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21370P07954Espacenet
EP 4650780 A22025-11-198075P07954Espacenet
EP 4641201 A22025-10-298207P07954Espacenet
JP 2025517969 A2025-06-128207P07954Espacenet
JP 2025517970 A2025-06-128075P07954Espacenet
JP 2024123008 A2024-09-106298P07954Espacenet
JP 2023521663 A2023-05-25369P07954Espacenet
US 11446398 B22022-09-2033058P07954Espacenet
JP 2022524081 A2022-04-27136029P07954Espacenet
JP 2021530985 A2021-11-18477P07954Espacenet

1 to 10 of 48

See all 48 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,810

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFH papersNewest fiscal year
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene572025
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer552025
P30CA008748Cancer Center Support Grant472025
ZIDBC011089Clinical Nursing and Data Management Core402025
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene342025
P30CA016672Cancer Center Support Grant292025
ZICBC011044Tissue Processing-Sequencing Facility202025
ZIABC010696Study of Hereditary Renal and Other Familial Syndromes132025
ZIABC011488Targeting Cancer Through Modifications and Metabolism112025
ZIABC011648Targeting Genetic and Metabolic Alterations in Distinct Subtypes of RCC102025

1 to 10 of 1,810Source NIH's project files

See all 1,810 nih grants

Papers3,968

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation.Adv Sci (Weinh)202642801604PubTator, text miningPubMed
Clinical Insights and Therapeutic Strategies for Fumarate Hydratase-Deficient Renal Cell Carcinoma: A Case Report with Literature ReviewCurr Med Imaging202642764568PubTator, text miningPubMed
Emerging patterns of kidney cancer in young adults: where do we stand?Crit Rev Oncol Hematol202642764100PubTator, text miningPubMed
Oncometabolites in Cancer Metabolism: Mechanistic Insights and Biomarker Potential- A Narrative Review.Health Sci Rep202642621358PubTator, text miningPubMed
Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase.Cell Rep202642599801PubTator, text miningPubMed
Fumarate hydratase downregulation in myocardial tissue: a potential biomarker for death from mechanical asphyxia.Forensic Sci Med Pathol202642579241PubTator, text miningPubMed
Fumarate hydratase suppresses glioblastoma progression by restricting fumarate-mediated succination of TRIM17.J Biol Chem202642567523PubTator, text miningPubMed
Dissecting a Diagnostic Enigma, Multiple Bilateral Facial Nodules in a Middle Aged Woman.Am J Dermatopathol202642566391PubTator, text miningPubMed
Fumarate and fumarate hydratase: an immunometabolite regulator of inflammation and diseases.Front Immunol202642528603PubTator, text miningPubMed
[Hereditary leiomyomatosis and renal cell carcinoma syndrome : Pathological features, diagnostics, and clinical implications].Pathologie (Heidelb)202642521857PubTator, text miningPubMed

1 to 10 of 3,968

See all 3,968 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2271

GET https://conductscience.org/api/genes/v1/2271/patents?page=2