Gene · 2271
FH: fumarate hydratase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FH: fumarate hydratase. Genes, record 2271. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2271
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P07954 | Fumarate hydratase, mitochondrial | 510 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents48
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 370 | P07954 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8075 | P07954 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8207 | P07954 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8207 | P07954 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8075 | P07954 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6298 | P07954 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 369 | P07954 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 33058 | P07954 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 136029 | P07954 | Espacenet |
| JP 2021530985 A | 2021-11-18 | 477 | P07954 | Espacenet |
1 to 10 of 48
See all 48 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,810
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FH papers | Newest fiscal year |
|---|---|---|---|
| ZIABC011038 | Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene | 57 | 2025 |
| ZIABC011028 | Clinical Studies of the Molecular Genetic Basis of Kidney Cancer | 55 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 47 | 2025 |
| ZIDBC011089 | Clinical Nursing and Data Management Core | 40 | 2025 |
| ZIABC011043 | Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene | 34 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 29 | 2025 |
| ZICBC011044 | Tissue Processing-Sequencing Facility | 20 | 2025 |
| ZIABC010696 | Study of Hereditary Renal and Other Familial Syndromes | 13 | 2025 |
| ZIABC011488 | Targeting Cancer Through Modifications and Metabolism | 11 | 2025 |
| ZIABC011648 | Targeting Genetic and Metabolic Alterations in Distinct Subtypes of RCC | 10 | 2025 |
1 to 10 of 1,810Source NIH's project files
See all 1,810 nih grantsPapers3,968
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation. | Adv Sci (Weinh) | 2026 | 42801604 | PubTator, text mining | PubMed |
| Clinical Insights and Therapeutic Strategies for Fumarate Hydratase-Deficient Renal Cell Carcinoma: A Case Report with Literature Review | Curr Med Imaging | 2026 | 42764568 | PubTator, text mining | PubMed |
| Emerging patterns of kidney cancer in young adults: where do we stand? | Crit Rev Oncol Hematol | 2026 | 42764100 | PubTator, text mining | PubMed |
| Oncometabolites in Cancer Metabolism: Mechanistic Insights and Biomarker Potential- A Narrative Review. | Health Sci Rep | 2026 | 42621358 | PubTator, text mining | PubMed |
| Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase. | Cell Rep | 2026 | 42599801 | PubTator, text mining | PubMed |
| Fumarate hydratase downregulation in myocardial tissue: a potential biomarker for death from mechanical asphyxia. | Forensic Sci Med Pathol | 2026 | 42579241 | PubTator, text mining | PubMed |
| Fumarate hydratase suppresses glioblastoma progression by restricting fumarate-mediated succination of TRIM17. | J Biol Chem | 2026 | 42567523 | PubTator, text mining | PubMed |
| Dissecting a Diagnostic Enigma, Multiple Bilateral Facial Nodules in a Middle Aged Woman. | Am J Dermatopathol | 2026 | 42566391 | PubTator, text mining | PubMed |
| Fumarate and fumarate hydratase: an immunometabolite regulator of inflammation and diseases. | Front Immunol | 2026 | 42528603 | PubTator, text mining | PubMed |
| [Hereditary leiomyomatosis and renal cell carcinoma syndrome : Pathological features, diagnostics, and clinical implications]. | Pathologie (Heidelb) | 2026 | 42521857 | PubTator, text mining | PubMed |
1 to 10 of 3,968
See all 3,968 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2271
GET https://conductscience.org/api/genes/v1/2271/patents?page=2