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Gene · 2272

FHIT: fragile histidine triad diadenosine triphosphatase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FHIT: fragile histidine triad diadenosine triphosphatase. Genes, record 2272. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2272

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Gene

Symbol
FHIT
HGNC
Name
fragile histidine triad diadenosine triphosphatase
HGNC
NCBI Gene ID
2272
NCBI Gene
HGNC ID
HGNC:3701
HGNC
Ensembl
ENSG00000189283
NCBI Gene
Aliases
AP3Aase, FRA3B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49789Bis(5'-adenosyl)-triphosphatase1479Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025024198 A2025-02-1912663P49789Espacenet
EP 4484957 A12025-01-0178P49789Espacenet
JP 2024123008 A2024-09-106291P49789Espacenet
JP 2024123008 A2024-09-106292P49789Espacenet
JP 2024123008 A2024-09-106293P49789Espacenet
JP 2024123008 A2024-09-106295P49789Espacenet
WO 2023162878 A2023-08-3178P49789Espacenet
US 11446398 B22022-09-2032829P49789Espacenet
US 11446398 B22022-09-2032830P49789Espacenet
US 11446398 B22022-09-2032831P49789Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,604

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFHIT papersNewest fiscal year
P30CA016672Cancer Center Support Grant312025
P30CA056036Translational Research in Cancer212025
P30CA008748Cancer Center Support Grant142025
P30CA016058Cancer Center Support Grant142025
P30CA015704Cancer Center Support Grant82025
P30CA046934University of Colorado Cancer Center Support Grant72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA076292Moffitt Cancer Center Support Grant52025

1 to 10 of 1,604Source NIH's project files

See all 1,604 nih grants

Papers2,915

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries.Adv Sci (Weinh)202642801564PubTator, text miningPubMed
In silico protein structure analysis of nine deleterious NIT1 missense mutations identified in human cancers.MicroPubl Biol202642564583PubTator, text miningPubMed
[Retracted] Effects of FHIT gene on proliferation and apoptosis of osteosarcoma cells.Oncol Lett202642524123PubTator, text miningPubMed
Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis.Sci Rep202642277116PubTator, text miningPubMed
Depletion of NAT10 in T cells attenuates metabolic dysfunction-associated steatohepatitis in mice.Hepatol Commun202642275589PubTator, text miningPubMed
Rexiao Kuining decoction ameliorates ulcerative colitis by restoring immune homeostasis via the protein kinase C alpha-FMS-like tyrosine kinase 3 ligand axis: multi-omics evidence.J Ethnopharmacol202642264446PubTator, text miningPubMed
FHIT suppresses cervical squamous cell carcinoma progression by negatively regulating UBE2I-mediated SUMO modification of NOTCH1.Cell Signal202642119835PubTator, text miningPubMed
Molecular heterogeneity of HPV-associated cancers and strategies to overcome treatment resistance.Cancer Heterog Plast202641938668PubTator, text miningPubMed
Genetic Influences on Disease-Modifying Therapy Response in Multiple Sclerosis: Current Insights and Future Directions.Balkan Med J202641918263PubTator, text miningPubMed
Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B.J Biol Chem202641895442PubTator, text miningPubMed

1 to 10 of 2,915

See all 2,915 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2272

GET https://conductscience.org/api/genes/v1/2272/patents?page=2