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Gene · 2273

FHL1: four and a half LIM domains 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FHL1: four and a half LIM domains 1. Genes, record 2273. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2273

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Gene

Symbol
FHL1
HGNC
Name
four and a half LIM domains 1
HGNC
NCBI Gene ID
2273
NCBI Gene
HGNC ID
HGNC:3702
HGNC
Ensembl
ENSG00000022267
NCBI Gene
Aliases
FCMSU, FHL-1, FHL1A, FHL1B, FLH1A, KYO-T, KYOT, MGC111107, RBMX1A, RBMX1B, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA, bA535K18.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13642Four and a half LIM domains protein 13234Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446624Q13642Espacenet
JP 2026004568 A2026-01-1446630Q13642Espacenet
JP 2025147176 A2025-10-065406Q13642Espacenet
JP 2025147176 A2025-10-065407Q13642Espacenet
JP 2025529142 A2025-09-046391Q13642Espacenet
US 12371689 B22025-07-296391Q13642Espacenet
JP 2025028160 A2025-02-285406Q13642Espacenet
JP 2025028160 A2025-02-285407Q13642Espacenet
KR 1020250010750 A2025-01-215406Q13642Espacenet
KR 1020250010750 A2025-01-215407Q13642Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,075

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFHL1 papersNewest fiscal year
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies112025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases62025
P30CA016672Cancer Center Support Grant42025
P30CA023108Cancer Center Support Grant42025
P01CA108671Myeloproliferative Neoplasms-Research Consortium32025
P20GM113132The Institute for Biomolecular Targeting32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA006973Regional Oncology Research Center32025
P30CA014520UW Comprehensive Cancer Center Support32025
R01DK110023C3 Glomerulopathy -- A Collaborative Study32025

1 to 10 of 1,075Source NIH's project files

See all 1,075 nih grants

Papers1,852

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Biochemical and Genetic Architecture of Geographic Atrophy: The Role of the FHL-1/CFH Axis and the Paradigm of RNA Interference Therapeutics.Biomedicines202642652191PubTator, text miningPubMed
Systemic and local dysregulation of the complement system in glioma: a comprehensive systematic review.Clin Transl Oncol202642627589PubTator, text miningPubMed
Transcript isoform switching during embryonic and post-hatch development of broiler breast muscle.Poult Sci202642617261PubTator, text miningPubMed
Screening Potential Diagnostic Biomarkers of Lung Adenocarcinoma Related to Immune Infiltration Based on Single-Cell Proteomic Integration Analysis.Can Respir J202642608948PubTator, text miningPubMed
Complement factor H in cancer biology: intracellular functions, tumor-host interactions, and systemic context.Front Immunol202642592211PubTator, text miningPubMed
Impaired Myogenic Differentiation Is a Shared Feature Across Genetic Myopathies.Int J Mol Sci202642511681PubTator, text miningPubMed
Novel FHL1 Mutation Associated With Reducing Body Myopathy.Cureus202642326197PubTator, text miningPubMed
Application of ultrasound and methylation omics detection in the diagnosis of endometrial cancer.Front Oncol202642318465PubTator, text miningPubMed
Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review.BMC Cardiovasc Disord202642304238PubTator, text miningPubMed
Circadian clock-related transcription factors Reveille 1 and Reveille 8 regulate the O-acetylserine cluster genes and sulfur homeostasis.Plant Physiol202642288963PubTator, text miningPubMed

1 to 10 of 1,852

See all 1,852 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2273

GET https://conductscience.org/api/genes/v1/2273/patents?page=2