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Gene · 2274

FHL2: four and a half LIM domains 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FHL2: four and a half LIM domains 2. Genes, record 2274. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2274

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Gene

Symbol
FHL2
HGNC
Name
four and a half LIM domains 2
HGNC
NCBI Gene ID
2274
NCBI Gene
HGNC ID
HGNC:3703
HGNC
Ensembl
ENSG00000115641
NCBI Gene
Aliases
AAG11, DRAL, FHL-2, SLIM-3, SLIM3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14192Four and a half LIM domains protein 22794Ensembl, GeneID, HGNC

Source UniProt

Patents80

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446643Q14192Espacenet
JP 2026004568 A2026-01-1446646Q14192Espacenet
JP 2026004568 A2026-01-1446647Q14192Espacenet
JP 2026004568 A2026-01-1446648Q14192Espacenet
JP 2026004568 A2026-01-1446649Q14192Espacenet
JP 2026004568 A2026-01-1446650Q14192Espacenet
JP 2026004568 A2026-01-1446651Q14192Espacenet
EP 4650780 A22025-11-195461Q14192Espacenet
JP 2025517970 A2025-06-125461Q14192Espacenet
US 11446398 B22022-09-2032803Q14192Espacenet

1 to 10 of 80

See all 80 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,009

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFHL2 papersNewest fiscal year
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30CA016056Roswell Park Cancer Center Support Grant62025
U54CA1323831/2 Partnership for the Advancement of Cancer Research: NMSU & Fred Hutch42025
P30CA016058Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA054174Mays Cancer Center at UT Health SA32025
P30CA068485Cancer Center Support Grant32025
R01CA174777AR Gene Rearrangements and AR Signaling in Prostate Cancer32025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects32025
ZIAAI000647Genes And Gene Products As Immunoadjuvants32025

1 to 10 of 1,009Source NIH's project files

See all 1,009 nih grants

Papers1,620

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DNPH1 exerts context-dependent tumor-promoting and -repressing functions during melanoma development.J Invest Dermatol202642772593PubTator, text miningPubMed
FHL2 production enabled new insight into its flexibility and unexpected binding stoichiometry with β-catenin.J Struct Biol X202642668614PubTator, text miningPubMed
A machine learning approach to identify key epigenetic transcripts for ageing research in human blood (Epitage).Biogerontology202642484919PubTator, text miningPubMed
DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae.Cureus202642471918PubTator, text miningPubMed
Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure.Acta Pharmacol Sin202642362853PubTator, text miningPubMed
Clinical, biological and cytometric characteristics of two patients with a homozygous A91VPRF1 mutation.Clin Transl Immunology202642339341PubTator, text miningPubMed
Correction to "FHL2 Expression by Cancer-Associated Fibroblasts Promotes Metastasis and Angiogenesis in Lung Adenocarcinoma".Int J Cancer202642290546PubTator, text miningPubMed
Chronological age estimation using CpG methylation signatures in Pakistani population.Int J Legal Med202642252362PubTator, text miningPubMed
Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk.EMBO J202642192127PubTator, text miningPubMed
Mitochondrial flagella-like extensions (MitoFLARE) dysfunction triggers STING-mediated immune dysregulation in sepsis.Nat Commun202642185292PubTator, text miningPubMed

1 to 10 of 1,620

See all 1,620 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2274

GET https://conductscience.org/api/genes/v1/2274/patents?page=2