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Gene · 2280

FKBP1A: FKBP prolyl isomerase 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FKBP1A: FKBP prolyl isomerase 1A. Genes, record 2280. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2280

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Gene

Symbol
FKBP1A
HGNC
Name
FKBP prolyl isomerase 1A
HGNC
NCBI Gene ID
2280
NCBI Gene
HGNC ID
HGNC:3711
HGNC
Ensembl
ENSG00000088832
NCBI Gene
Aliases
FKBP-12, FKBP-1A, FKBP1, FKBP12, FKBP12C, PKC12, PKCI2, PPIASE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P62942Peptidyl-prolyl cis-trans isomerase FKBP1A108113Ensembl, GeneID, HGNC

Source UniProt

Patents251

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026127113 A2026-06-189P62942Espacenet
US 12624353 B22026-05-12488P62942Espacenet
US 12624353 B22026-05-12491P62942Espacenet
US 12624354 B22026-05-12488P62942Espacenet
US 12624354 B22026-05-12491P62942Espacenet
JP 2026062659 A2026-04-10488P62942Espacenet
JP 2026062659 A2026-04-10491P62942Espacenet
US 12570972 B22026-03-10488P62942Espacenet
US 12570972 B22026-03-10491P62942Espacenet
US 12544448 B22026-02-103P62942Espacenet

1 to 10 of 251

See all 251 patents

Drugs8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EVEROLIMUSCHEMBL1908360FK506-binding protein 1A inhibitorINHIBITORChEMBL
OLOCROLIMUSCHEMBL3545142FK506-binding protein 1A inhibitorINHIBITORChEMBL
PIMECROLIMUSCHEMBL1200686FK506-binding protein 1A inhibitorINHIBITORChEMBL
SIROLIMUSCHEMBL413FK506-binding protein 1A inhibitorINHIBITORChEMBL
TACROLIMUSCHEMBL3989887FK506-binding protein 1A inhibitorINHIBITORChEMBL
TACROLIMUS ANHYDROUSCHEMBL269732FK506-binding protein 1A inhibitorINHIBITORChEMBL
TEMSIROLIMUSCHEMBL1201182FK506-binding protein 1A inhibitorINHIBITORChEMBL
ZOTAROLIMUSCHEMBL219410FK506-binding protein 1A inhibitorINHIBITORChEMBL

Trials1,687

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,367

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFKBP1A papersNewest fiscal year
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)82025
P30CA008748Cancer Center Support Grant62025
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity62025
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation62025
P30CA006973Regional Oncology Research Center52025
P30CA016672Cancer Center Support Grant52025
R01EY026635Protein-polymer nanomedicine for Sjogren's Syndrome52025
R25NS076445Summer Program for Undergraduate Rising Stars (SPURS), a Columbia University biomedical sciences pipeline program52025
P30CA082103Cancer Center Support Grant42025
P50CA126752SPORE in Lymphoma42025

1 to 10 of 1,367Source NIH's project files

See all 1,367 nih grants

Papers1,820

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSGS-Drug: Generation-Time Dual-Pocket Guidance for Non-Symmetric Dual-Target Molecular Design.J Chem Inf Model202642573395PubTator, text miningPubMed
Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutics.Mol Psychiatry202642547801PubTator, text miningPubMed
Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma.Signal Transduct Target Ther202642493498PubTator, text miningPubMed
Engineering CAR T Cells for Hepatocellular Carcinoma Recurrence after Liver Transplantation.bioRxiv202642427600PubTator, text miningPubMed
FKBP52 in cancer biology and therapy: molecular mechanisms, signalling networks, and drug targeting of the FKBP protein family.Biochem Pharmacol202642114681PubTator, text miningPubMed
HLA-A*11:01 and HLA-C*03 Binding to FKBP1A Influences the Efficacy of Tacrolimus in Myasthenia Gravis Subgroups.HLA202641925081PubTator, text miningPubMed
Identification of a Calcium-Related Prognostic Signature and Validation of CACNA1B as a Driver of Metastasis in Hepatocellular Carcinoma.J Hepatocell Carcinoma202641909196PubTator, text miningPubMed
Blood-based epigenetic biomarkers in rheumatoid arthritis: current knowledge and future perspectives.Front Immunol202641798917PubTator, text miningPubMed
Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy.Clin Kidney J202641788620PubTator, text miningPubMed
Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study.J Cachexia Sarcopenia Muscle202641782349PubTator, text miningPubMed

1 to 10 of 1,820

See all 1,820 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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