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Gene · 22806

IKZF3: IKAROS family zinc finger 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IKZF3: IKAROS family zinc finger 3. Genes, record 22806. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22806

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Gene

Symbol
IKZF3
HGNC
Name
IKAROS family zinc finger 3
HGNC
NCBI Gene ID
22806
NCBI Gene
HGNC ID
HGNC:13178
HGNC
Ensembl
ENSG00000161405
NCBI Gene
Aliases
AIO, AIOLOS, Aiolos, IMD84, ZNFN1A3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UKT9Zinc finger protein Aiolos5094Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4781985 A22026-07-2912Q9UKT9Espacenet
JP 2026048701 A2026-03-17328Q9UKT9Espacenet
JP 2026505349 A2026-02-132Q9UKT9Espacenet
JP 2026502937 A2026-01-2712Q9UKT9Espacenet
JP 2026501039 A2026-01-1412Q9UKT9Espacenet
WO 2025226767 A12025-10-3012Q9UKT9Espacenet
EP 4641201 A22025-10-296735Q9UKT9Espacenet
EP 4641202 A22025-10-295189Q9UKT9Espacenet
JP 2025147176 A2025-10-0615164Q9UKT9Espacenet
KR 1020250138280 A2025-09-192Q9UKT9Espacenet

1 to 10 of 64

See all 64 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,840

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIKZF3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P50CA186781Mayo Clinic Multiple Myeloma SPORE162025
R01CA214608The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase162025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias152025
P30CA021765Cancer Center Support Grant (CCSG)112025
P30CA016672Cancer Center Support Grant102025
P30CA016058Cancer Center Support Grant92025
R01CA218278Degrading therapeutically important kinases using small molecules92025
P01CA155258Integrative Oncogenomics of Multiple Myeloma72025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant72025

1 to 10 of 1,840Source NIH's project files

See all 1,840 nih grants

Papers2,106

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-Ancestry Genome-wide Association Analyses Identify Shared and Specific Genetic Architecture in Mild and Moderate-to-Severe Asthma.medRxiv202642818167PubTator, text miningPubMed
Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women.Biomolecules202642793205PubTator, text miningPubMed
Genetically Predicted Gene Expression and Circulating Metabolites Associated with Cervical High-Grade Squamous Intraepithelial Lesion: A Mendelian Randomization Study.Int J Womens Health202642701819PubTator, text miningPubMed
CXXC1-dependent IRF4 activity promotes myeloma cell fitness and sustains lenalidomide resistance.Blood202642685001PubTator, text miningPubMed
Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.J Med Chem202642677819PubTator, text miningPubMed
Proteomic Insights Into Human Induced Regulatory T Cells: The Role of LPXN and CD160 in Immune Suppression.Mol Cell Proteomics202642624209PubTator, text miningPubMed
Identification of genetic variants associated with idiopathic inflammatory myopathies via cross-trait analysis with B cell lymphomas.HGG Adv202642499187PubTator, text miningPubMed
IL-7-glucose-Aiolos axis orchestrates pathogenic CD8+ T cell function in spondyloarthritis.Proc Natl Acad Sci U S A202642461767PubTator, text miningPubMed
Oncogenic DNMT3B as a therapeutic target for cervical cancer.Chin Med J (Engl)202642402721PubTator, text miningPubMed
Identification of XZ8078 as a Dual-Target Degrader Targeting PARP1 and IKZF3 for Broad Spectrum Anticancer Treatment.J Med Chem202642380731PubTator, text miningPubMed

1 to 10 of 2,106

See all 2,106 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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