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Gene · 22807

IKZF2: IKAROS family zinc finger 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IKZF2: IKAROS family zinc finger 2. Genes, record 22807. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22807

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Gene

Symbol
IKZF2
HGNC
Name
IKAROS family zinc finger 2
HGNC
NCBI Gene ID
22807
NCBI Gene
HGNC ID
HGNC:13177
HGNC
Ensembl
ENSG00000030419
NCBI Gene
Aliases
ANF1A2, HELIOS, Helios, ICHAD, IMDIA, ZNF1A2, ZNFN1A2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UKS7Zinc finger protein Helios5268Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22347Q9UKS7Espacenet
JP 2026048701 A2026-03-17330Q9UKS7Espacenet
JP 2026505349 A2026-02-134Q9UKS7Espacenet
JP 2026505362 A2026-02-1352Q9UKS7Espacenet
EP 4661884 A22025-12-1752Q9UKS7Espacenet
EP 4641201 A22025-10-2915924Q9UKS7Espacenet
JP 2025147176 A2025-10-0615163Q9UKS7Espacenet
KR 1020250138280 A2025-09-194Q9UKS7Espacenet
JP 2025525390 A2025-08-053583Q9UKS7Espacenet
JP 2025517969 A2025-06-1215924Q9UKS7Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,938

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIKZF2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant242025
P30CA008748Cancer Center Support Grant212025
P30CA021765Cancer Center Support Grant (CCSG)142025
P01AI042288Immune Function and the Progression to Type 1 Diabetes112025
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy102025
R01DK106191The CD226 costimulatory axis in type 1 diabetes92025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies82025
P30AR070253Joint Biology Consortium Resource-based Center72025
P30CA013696Cancer Center Support Grant72025
R35CA197695Translating genomic discoveries to improved outcomes for high risk acute leukemia72025

1 to 10 of 1,938Source NIH's project files

See all 1,938 nih grants

Papers2,253

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-cell landscape of human liver sinusoidal γδ T cells in the context of latent human cytomegalovirus infection.Nat Commun202642811027PubTator, text miningPubMed
Tissue repair in the central nervous system: the epigenetic programming of regulatory T cells.Front Immunol202642724996PubTator, text miningPubMed
Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.J Med Chem202642677819PubTator, text miningPubMed
TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation.Immunity202642520795PubTator, text miningPubMed
Highly suppressive functional CCR7 low Treg subset cells may correlate with poor prognosis of B-ALL.Hematology202642517226PubTator, text miningPubMed
Early transcriptional signature in chikungunya predicts chronic arthralgia and reveals deficient antiviral response.J Infect Dis202642478964PubTator, text miningPubMed
BLIMP-1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses.Immunol Cell Biol202642448314PubTator, text miningPubMed
Helios expression in naive CD4+ T cells decreases from neonates to older adults.Clin Exp Immunol202642413959PubTator, text miningPubMed
Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K + Supramolecular Attack Particles.bioRxiv202642395370PubTator, text miningPubMed
CD25+CD27+CD70- alloantigen-specific Tregs: promising stable immunotherapy for transplantation.Front Immunol202642358982PubTator, text miningPubMed

1 to 10 of 2,253

See all 2,253 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/22807

GET https://conductscience.org/api/genes/v1/22807/patents?page=2