Gene · 22807
IKZF2: IKAROS family zinc finger 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IKZF2: IKAROS family zinc finger 2. Genes, record 22807. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22807
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UKS7 | Zinc finger protein Helios | 526 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents74
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026120675 A | 2026-07-22 | 347 | Q9UKS7 | Espacenet |
| JP 2026048701 A | 2026-03-17 | 330 | Q9UKS7 | Espacenet |
| JP 2026505349 A | 2026-02-13 | 4 | Q9UKS7 | Espacenet |
| JP 2026505362 A | 2026-02-13 | 52 | Q9UKS7 | Espacenet |
| EP 4661884 A2 | 2025-12-17 | 52 | Q9UKS7 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15924 | Q9UKS7 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15163 | Q9UKS7 | Espacenet |
| KR 1020250138280 A | 2025-09-19 | 4 | Q9UKS7 | Espacenet |
| JP 2025525390 A | 2025-08-05 | 3583 | Q9UKS7 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15924 | Q9UKS7 | Espacenet |
1 to 10 of 74
See all 74 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,938
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IKZF2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 24 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 14 | 2025 |
| P01AI042288 | Immune Function and the Progression to Type 1 Diabetes | 11 | 2025 |
| U19AI082630 | Durable Alteration of the Human Immune system after Infection or Immunotherapy | 10 | 2025 |
| R01DK106191 | The CD226 costimulatory axis in type 1 diabetes | 9 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 8 | 2025 |
| P30AR070253 | Joint Biology Consortium Resource-based Center | 7 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 7 | 2025 |
| R35CA197695 | Translating genomic discoveries to improved outcomes for high risk acute leukemia | 7 | 2025 |
1 to 10 of 1,938Source NIH's project files
See all 1,938 nih grantsPapers2,253
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Single-cell landscape of human liver sinusoidal γδ T cells in the context of latent human cytomegalovirus infection. | Nat Commun | 2026 | 42811027 | PubTator, text mining | PubMed |
| Tissue repair in the central nervous system: the epigenetic programming of regulatory T cells. | Front Immunol | 2026 | 42724996 | PubTator, text mining | PubMed |
| Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors. | J Med Chem | 2026 | 42677819 | PubTator, text mining | PubMed |
| TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation. | Immunity | 2026 | 42520795 | PubTator, text mining | PubMed |
| Highly suppressive functional CCR7 low Treg subset cells may correlate with poor prognosis of B-ALL. | Hematology | 2026 | 42517226 | PubTator, text mining | PubMed |
| Early transcriptional signature in chikungunya predicts chronic arthralgia and reveals deficient antiviral response. | J Infect Dis | 2026 | 42478964 | PubTator, text mining | PubMed |
| BLIMP-1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses. | Immunol Cell Biol | 2026 | 42448314 | PubTator, text mining | PubMed |
| Helios expression in naive CD4+ T cells decreases from neonates to older adults. | Clin Exp Immunol | 2026 | 42413959 | PubTator, text mining | PubMed |
| Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K + Supramolecular Attack Particles. | bioRxiv | 2026 | 42395370 | PubTator, text mining | PubMed |
| CD25+CD27+CD70- alloantigen-specific Tregs: promising stable immunotherapy for transplantation. | Front Immunol | 2026 | 42358982 | PubTator, text mining | PubMed |
1 to 10 of 2,253
See all 2,253 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/22807
GET https://conductscience.org/api/genes/v1/22807/patents?page=2