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Gene · 22861

NLRP1: NLR family pyrin domain containing 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NLRP1: NLR family pyrin domain containing 1. Genes, record 22861. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22861

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Gene

Symbol
NLRP1
HGNC
Name
NLR family pyrin domain containing 1
HGNC
NCBI Gene ID
22861
NCBI Gene
HGNC ID
HGNC:14374
HGNC
Ensembl
ENSG00000091592
NCBI Gene
Aliases
AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, DKFZp586O1822, JRRP, KIAA0926, MSPC, NAC, NALP1, PP1044, SLEV1, VAMAS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9C000NACHT, LRR and PYD domains-containing protein 11,47312Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1917360Q9C000Espacenet
EP 4641201 A22025-10-2921426Q9C000Espacenet
EP 4641202 A22025-10-291209Q9C000Espacenet
JP 2025517969 A2025-06-1221426Q9C000Espacenet
JP 2025517970 A2025-06-1217360Q9C000Espacenet
KR 1020250017231 A2025-02-041209Q9C000Espacenet
JP 2024522216 A2024-06-1191Q9C000Espacenet
KR 1020240022540 A2024-02-2091Q9C000Espacenet
US 11446398 B22022-09-2057223Q9C000Espacenet
US 11446398 B22022-09-2057224Q9C000Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,899

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNLRP1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
R01AI137168Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis222025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation162025
R01AI124346Innate immune signaling and stress response152025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing112025
ZIAAI001032Pathophysiological Actions of Anthrax Virulence Determinants112025
R01AI163170Redox control of the NLRP1 inflammasome92025
P01CA019014Viral Oncogenesis, Latency, and Replication72025
R01AI029564Molecular and Functional Analysis of Innate Immune Receptors72025
R01CA266478Prolidase Inhibitors as Therapeutic Agents for Acute Myeloid Leukemia72025

1 to 10 of 1,899Source NIH's project files

See all 1,899 nih grants

Papers3,738

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing.Immunol Res202642821198PubTator, text miningPubMed
A New Gain-of-Function NLRP1 Variant Is Associated with Inflammasome Activation and Disease Severity in SLC25A38 Congenital Sideroblastic Anemia Case Report.J Pers Med202642783502PubTator, text miningPubMed
Inflammasome-derived biomarkers in wound healing: linking tissue repair, chronic inflammation, fibrosis, and precision therapeutics.Mol Biol Rep202642776304PubTator, text miningPubMed
[Expression of Concern] Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro.Int J Mol Med202642757480PubTator, text miningPubMed
Beyond NLRP3: expanding the spectrum of NLR-associated autoinflammatory diseases.Rheumatology (Oxford)202642755046PubTator, text miningPubMed
Intrinsically disordered regions in the NLRP family of receptors act as regulatory hubs for inflammasome condensation and activation.Front Immunol202642745995PubTator, text miningPubMed
Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.J Clin Invest202642741941PubTator, text miningPubMed
Epistatic Interactions Among Inflammasome Gene Variants Are Associated with Reduced Risk of Paracoccidioidomycosis.J Infect Dis202642715385PubTator, text miningPubMed
Innate immune sensors of inflammasomes and PANoptosomes: structural-mechanistic insights and therapeutic implications.Cell Res202642693250PubTator, text miningPubMed
PAPASH-like disease associated with a heterozygous NLRP1 variant complicated by papulopustular folliculitis.JAAD Case Rep202642668523PubTator, text miningPubMed

1 to 10 of 3,738

See all 3,738 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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