Gene · 22861
NLRP1: NLR family pyrin domain containing 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NLRP1: NLR family pyrin domain containing 1. Genes, record 22861. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22861
On this page
Gene
- Aliases
- AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, DKFZp586O1822, JRRP, KIAA0926, MSPC, NAC, NALP1, PP1044, SLEV1, VAMAS1
- NCBI Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9C000 | NACHT, LRR and PYD domains-containing protein 1 | 1,473 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 17360 | Q9C000 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 21426 | Q9C000 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 1209 | Q9C000 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 21426 | Q9C000 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 17360 | Q9C000 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 1209 | Q9C000 | Espacenet |
| JP 2024522216 A | 2024-06-11 | 91 | Q9C000 | Espacenet |
| KR 1020240022540 A | 2024-02-20 | 91 | Q9C000 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 57223 | Q9C000 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 57224 | Q9C000 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,899
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NLRP1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 25 | 2025 |
| R01AI137168 | Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis | 22 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 16 | 2025 |
| R01AI124346 | Innate immune signaling and stress response | 15 | 2025 |
| R01AI124491 | NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing | 11 | 2025 |
| ZIAAI001032 | Pathophysiological Actions of Anthrax Virulence Determinants | 11 | 2025 |
| R01AI163170 | Redox control of the NLRP1 inflammasome | 9 | 2025 |
| P01CA019014 | Viral Oncogenesis, Latency, and Replication | 7 | 2025 |
| R01AI029564 | Molecular and Functional Analysis of Innate Immune Receptors | 7 | 2025 |
| R01CA266478 | Prolidase Inhibitors as Therapeutic Agents for Acute Myeloid Leukemia | 7 | 2025 |
1 to 10 of 1,899Source NIH's project files
See all 1,899 nih grantsPapers3,738
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing. | Immunol Res | 2026 | 42821198 | PubTator, text mining | PubMed |
| A New Gain-of-Function NLRP1 Variant Is Associated with Inflammasome Activation and Disease Severity in SLC25A38 Congenital Sideroblastic Anemia Case Report. | J Pers Med | 2026 | 42783502 | PubTator, text mining | PubMed |
| Inflammasome-derived biomarkers in wound healing: linking tissue repair, chronic inflammation, fibrosis, and precision therapeutics. | Mol Biol Rep | 2026 | 42776304 | PubTator, text mining | PubMed |
| [Expression of Concern] Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro. | Int J Mol Med | 2026 | 42757480 | PubTator, text mining | PubMed |
| Beyond NLRP3: expanding the spectrum of NLR-associated autoinflammatory diseases. | Rheumatology (Oxford) | 2026 | 42755046 | PubTator, text mining | PubMed |
| Intrinsically disordered regions in the NLRP family of receptors act as regulatory hubs for inflammasome condensation and activation. | Front Immunol | 2026 | 42745995 | PubTator, text mining | PubMed |
| Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency. | J Clin Invest | 2026 | 42741941 | PubTator, text mining | PubMed |
| Epistatic Interactions Among Inflammasome Gene Variants Are Associated with Reduced Risk of Paracoccidioidomycosis. | J Infect Dis | 2026 | 42715385 | PubTator, text mining | PubMed |
| Innate immune sensors of inflammasomes and PANoptosomes: structural-mechanistic insights and therapeutic implications. | Cell Res | 2026 | 42693250 | PubTator, text mining | PubMed |
| PAPASH-like disease associated with a heterozygous NLRP1 variant complicated by papulopustular folliculitis. | JAAD Case Rep | 2026 | 42668523 | PubTator, text mining | PubMed |
1 to 10 of 3,738
See all 3,738 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/22861
GET https://conductscience.org/api/genes/v1/22861/patents?page=2