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Gene · 2288

FKBP4: FKBP prolyl isomerase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FKBP4: FKBP prolyl isomerase 4. Genes, record 2288. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2288

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Gene

Symbol
FKBP4
HGNC
Name
FKBP prolyl isomerase 4
HGNC
NCBI Gene ID
2288
NCBI Gene
HGNC ID
HGNC:3720
HGNC
Ensembl
ENSG00000004478
NCBI Gene
Aliases
FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02790Peptidyl-prolyl cis-trans isomerase FKBP445912Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4825362 A12026-10-211Q02790Espacenet
EP 4803075 A12026-09-091Q02790Espacenet
EP 4650780 A22025-11-193Q02790Espacenet
EP 4641202 A22025-10-294280Q02790Espacenet
JP 2025517970 A2025-06-123Q02790Espacenet
JP 2025032204 A2025-03-1128479Q02790Espacenet
JP 2025505440 A2025-02-261Q02790Espacenet
KR 1020250017231 A2025-02-044280Q02790Espacenet
JP 2025009766 A2025-01-2092Q02790Espacenet
WO 2025005189 A2025-01-0292Q02790Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,240

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFKBP4 papersNewest fiscal year
R01NS073899The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function122025
ZIABC011032Post-translational modifications of Hsp9082025
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction82025
R01NS059690Molecular Chaperones and Small Molecules72025
ZIAES090057Glucocorticoid Hormone Action52025
P30CA008748Cancer Center Support Grant42025
P50CA097186The Pacific Northwest Prostate Cancer SPORE42025
P30AI027767UAB Center for AIDS Research (CFAR)32025
P30AI036214San Diego Center for AIDS Research (SD CFAR)32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,240Source NIH's project files

See all 1,240 nih grants

Papers1,741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploratory Transcriptomic, Genomic, Pharmacogenomic, and Cellular Evaluation of FKBP4 in Lung Adenocarcinoma.Biology (Basel)202642792605PubTator, text miningPubMed
Abnormally Low Hemoglobin A1c Due to a Heterozygous Alpha-Globin Variant (Hb I; HBA2 c.49A>G, p.Lys17Glu) in a Geriatric Patient.Cureus202642757138PubTator, text miningPubMed
SAV1 in Cooperation With FKBP52 Participates in Implantation.Adv Sci (Weinh)202642750339PubTator, text miningPubMed
Identification of Mitotic Catastrophe-related Prognostic Genes in Lung Adenocarcinoma via Transcriptome Analysis.J Vis Exp202642631570PubTator, text miningPubMed
Metabolism Pathway Blood Proteomic Differences in Lewy Body Dementia Compared to Alzheimer's Disease.Int J Mol Sci202642589529PubTator, text miningPubMed
FKBP52 dictates the dual role of p53 in hepatocellular carcinoma: Mutation-specific prognostic stratification and therapeutic implications.J Biol Chem202642556724PubTator, text miningPubMed
NOP2-regulated m5C methylation of FKBP4 in promoting lung adenocarcinoma progression.Exp Cell Res202642526734PubTator, text miningPubMed
Identification of Candidate Biomarkers Associated with Mitochondrial Dysfunction and SUMOylation in Heart Failure Based on Bioinformatics Approaches.J Vis Exp202642441434PubTator, text miningPubMed
Integrated multi-omics analysis identifies key microglial subpopulations and therapeutic targets in Parkinson's disease.Parkinsonism Relat Disord202642430983PubTator, text miningPubMed
Machine learning-driven development of a novel unfolded protein response-related gene signature for predicting lung adenocarcinoma patient prognosis.BMC Cancer202642401850PubTator, text miningPubMed

1 to 10 of 1,741

See all 1,741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2288

GET https://conductscience.org/api/genes/v1/2288/patents?page=2