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SIRT2: sirtuin 2

1 protein, 81 patents, 0 drugs, 0 trials, 2,765 NIH grants and 5,655 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSIRT2HGNC
Namesirtuin 2HGNC
NCBI Gene ID22933NCBI Gene
HGNC IDHGNC:10886HGNC
EnsemblENSG00000068903NCBI Gene
AliasesSIR2, SIR2L, SIR2L2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q8IXJ6NAD-dependent protein deacetylase sirtuin-238977Ensembl, GeneID, HGNCUniProt

Patents 81

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191278Q8IXJ6Espacenet
JP 2025517970 A2025-06-121278Q8IXJ6Espacenet
EP 4491229 A22025-01-15260Q8IXJ6Espacenet
EP 4487869 A22025-01-08445Q8IXJ6Espacenet
US 12161639 B22024-12-103Q8IXJ6Espacenet
WO 2024230934 A12024-11-14385Q8IXJ6Espacenet
JP 2024123008 A2024-09-108439Q8IXJ6Espacenet
KR 1020240027895 A2024-03-04632Q8IXJ6Espacenet
JP 2023036863 A2023-03-14632Q8IXJ6Espacenet
US 11446398 B22022-09-2079398Q8IXJ6Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2765

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant102,025NIH's project files
P30CA008748Cancer Center Support Grant92,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center92,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center82,025NIH's project files
P30AG013280Nathan Shock Centers of Excellence in Basic Biology of Aging (P30 Clinical Trial Not Allowed)72,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support62,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research52,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)52,025NIH's project files
R01AR078555Histone lactylation pathway in hair cycle: deacylases and their protein targets52,025NIH's project files
ZIAAG000363Aging Intervention Program52,025NIH's project files

Papers 5655

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819705PubTator, text miningPubMed
42812214PubTator, text miningPubMed
42811977PubTator, text miningPubMed
42798484PubTator, text miningPubMed
42788778PubTator, text miningPubMed
42781926PubTator, text miningPubMed
42778514PubTator, text miningPubMed
42753730PubTator, text miningPubMed
42750209PubTator, text miningPubMed
42742903PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license