Gene · 22937
SCAP: SREBF chaperone
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SCAP: SREBF chaperone. Genes, record 22937. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22937
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q12770 | Sterol regulatory element-binding protein cleavage-activating protein | 1,279 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents20
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65404 | Q12770 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 306 | Q12770 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2081 | Q12770 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3828 | Q12770 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3828 | Q12770 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 306 | Q12770 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2081 | Q12770 | Espacenet |
| JP 2025512445 A | 2025-04-17 | 2 | Q12770 | Espacenet |
| KR 1020250005108 A | 2025-01-09 | 2 | Q12770 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83859 | Q12770 | Espacenet |
1 to 10 of 20
See all 20 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,345
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SCAP papers | Newest fiscal year |
|---|---|---|---|
| R37AG013925 | Effect of Aging on Preadipocyte Differentiation | 10 | 2025 |
| P01AG062413 | Targeting Cellular Senescence to Extend Healthspan | 9 | 2025 |
| R33AG061456 | Translational Geroscience Network | 9 | 2025 |
| R01NS104332 | Determining the role of lipid droplets and their therapeutic potential in glioblastoma | 7 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| P01HL160487 | New Approaches to Reduce Residual Cardiovascular Risk | 4 | 2025 |
| P30AG013319 | San Antonio Nathan Shock Center of Excellence in the Biology of Aging | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,345Source NIH's project files
See all 1,345 nih grantsPapers1,943
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Indole-benzimidazole hybrids modulate lipid metabolism and promote autophagic and apoptotic signaling in breast cancer. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42722901 | PubTator, text mining | PubMed |
| SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes. | Biomol Ther (Seoul) | 2026 | 42676034 | PubTator, text mining | PubMed |
| HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation. | Cell Rep | 2026 | 42667615 | PubTator, text mining | PubMed |
| COPI Coatomer Regulates Several Steps of HDL Metabolism. | Arterioscler Thromb Vasc Biol | 2026 | 42592650 | PubTator, text mining | PubMed |
| S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via noncanonical SREBP2 signaling. | J Clin Invest | 2026 | 42550612 | PubTator, text mining | PubMed |
| mTORC1-regulated LDL receptor increasing and oxidized lipid accumulation in osteocytes participate in trauma-induced osteonecrosis of the femoral head. | Biochem Pharmacol | 2026 | 42537709 | PubTator, text mining | PubMed |
| SCAP-derived exosomes restore excitatory-inhibitory balance and attenuate glutamate-induced excitotoxicity via modulation of GABAergic signaling. | Neuroscience | 2026 | 42520916 | PubTator, text mining | PubMed |
| Association of SCAP Gene Polymorphisms with Ambulatory Blood Pressure Parameters in College Students. | Genes (Basel) | 2026 | 42510865 | PubTator, text mining | PubMed |
| Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis. | Front Immunol | 2026 | 42488674 | PubTator, text mining | PubMed |
| Serum lipidome remodeling in viral pneumonia: from pathophysiology to therapeutics. | Front Immunol | 2026 | 42440657 | PubTator, text mining | PubMed |
1 to 10 of 1,943
See all 1,943 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/22937
GET https://conductscience.org/api/genes/v1/22937/patents