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Gene · 22937

SCAP: SREBF chaperone

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCAP: SREBF chaperone. Genes, record 22937. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22937

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Gene

Symbol
SCAP
HGNC
Name
SREBF chaperone
HGNC
NCBI Gene ID
22937
NCBI Gene
HGNC ID
HGNC:30634
HGNC
Ensembl
ENSG00000114650
NCBI Gene
Aliases
KIAA0199
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12770Sterol regulatory element-binding protein cleavage-activating protein1,2792Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465404Q12770Espacenet
EP 4640849 A22025-10-29306Q12770Espacenet
EP 4641201 A22025-10-292081Q12770Espacenet
JP 2025529142 A2025-09-043828Q12770Espacenet
US 12371689 B22025-07-293828Q12770Espacenet
JP 2025519096 A2025-06-24306Q12770Espacenet
JP 2025517969 A2025-06-122081Q12770Espacenet
JP 2025512445 A2025-04-172Q12770Espacenet
KR 1020250005108 A2025-01-092Q12770Espacenet
US 11446398 B22022-09-2083859Q12770Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,345

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCAP papersNewest fiscal year
R37AG013925Effect of Aging on Preadipocyte Differentiation102025
P01AG062413Targeting Cellular Senescence to Extend Healthspan92025
R33AG061456Translational Geroscience Network92025
R01NS104332Determining the role of lipid droplets and their therapeutic potential in glioblastoma72025
P30DK063491Diabetes Research Center (DRC)52025
P01HL160487New Approaches to Reduce Residual Cardiovascular Risk42025
P30AG013319San Antonio Nathan Shock Center of Excellence in the Biology of Aging42025
P30CA006973Regional Oncology Research Center42025
P30CA008748Cancer Center Support Grant42025
P30CA016042Cancer Center Support Grant42025

1 to 10 of 1,345Source NIH's project files

See all 1,345 nih grants

Papers1,943

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Indole-benzimidazole hybrids modulate lipid metabolism and promote autophagic and apoptotic signaling in breast cancer.Naunyn Schmiedebergs Arch Pharmacol202642722901PubTator, text miningPubMed
SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes.Biomol Ther (Seoul)202642676034PubTator, text miningPubMed
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation.Cell Rep202642667615PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via noncanonical SREBP2 signaling.J Clin Invest202642550612PubTator, text miningPubMed
mTORC1-regulated LDL receptor increasing and oxidized lipid accumulation in osteocytes participate in trauma-induced osteonecrosis of the femoral head.Biochem Pharmacol202642537709PubTator, text miningPubMed
SCAP-derived exosomes restore excitatory-inhibitory balance and attenuate glutamate-induced excitotoxicity via modulation of GABAergic signaling.Neuroscience202642520916PubTator, text miningPubMed
Association of SCAP Gene Polymorphisms with Ambulatory Blood Pressure Parameters in College Students.Genes (Basel)202642510865PubTator, text miningPubMed
Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis.Front Immunol202642488674PubTator, text miningPubMed
Serum lipidome remodeling in viral pneumonia: from pathophysiology to therapeutics.Front Immunol202642440657PubTator, text miningPubMed

1 to 10 of 1,943

See all 1,943 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/22937

GET https://conductscience.org/api/genes/v1/22937/patents