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Gene · 22941

SHANK2: SH3 and multiple ankyrin repeat domains 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SHANK2: SH3 and multiple ankyrin repeat domains 2. Genes, record 22941. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22941

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Gene

Symbol
SHANK2
HGNC
Name
SH3 and multiple ankyrin repeat domains 2
HGNC
NCBI Gene ID
22941
NCBI Gene
HGNC ID
HGNC:14295
HGNC
Ensembl
ENSG00000162105
NCBI Gene
Aliases
AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UPX8SH3 and multiple ankyrin repeat domains protein 21,8492Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-293560Q9UPX8Espacenet
EP 4641201 A22025-10-2922159Q9UPX8Espacenet
JP 2025519096 A2025-06-243560Q9UPX8Espacenet
JP 2025517969 A2025-06-1222159Q9UPX8Espacenet
JP 2025032204 A2025-03-1135633Q9UPX8Espacenet
EP 4461818 A22024-11-1335633Q9UPX8Espacenet
JP 2023058610 A2023-04-2535633Q9UPX8Espacenet
US 11446398 B22022-09-2078561Q9UPX8Espacenet
JP 2022524081 A2022-04-27181532Q9UPX8Espacenet
US 11078247 B22021-08-0310237Q9UPX8Espacenet

1 to 10 of 13

See all 13 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,543

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSHANK2 papersNewest fiscal year
ZIANS003113Dynamic Structural Properties of Synapses62025
R01MH071316Rac-GEF signaling in dendritic spines52025
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea42025
R01GM121907Genomic basis of phenotypic variability of complex disorders42025
R01HD036071Genotype-Phenotype Relationships in Fragile X Families42025
R01MH101221Rare Mutations and Autism Spectrum Disorders42025
T32HG000035Interdisciplinary Training in Genome Sciences42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA016056Roswell Park Cancer Center Support Grant32025
R01MH074090Gene Dosage Imbalance in Neurodevelopmental Disorders32025

1 to 10 of 1,543Source NIH's project files

See all 1,543 nih grants

Papers1,856

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prenatal Folinic Acid in FRAA-Positive Pregnancies: Preschool Neurodevelopmental Outcomes from a Pilot RCT Follow-Up.Nutrients202642796952PubTator, text miningPubMed
Characterizing features of the genetic architecture underlying autism from a multi-ancestry perspective.Mol Psychiatry202642728317PubTator, text miningPubMed
Prenatal exposure to the plasticizer DEHP increases the likelihood of early-life autism and ADHD symptoms through epigenetic programming.Med202642727573PubTator, text miningPubMed
Frequently amplified SHANK2 promotes esophageal squamous cell carcinoma progression through the DVL/YAP axis.Oncogene202642675223PubTator, text miningPubMed
Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer's and Parkinson's Disease.Cells202642645161PubTator, text miningPubMed
Subcortical Dendritic Scaffolding in Autism Spectrum Disorder: A Testable ANK2-SCN2A-SHANK Framework.Int J Mol Sci202642450246PubTator, text miningPubMed
Social compatibility in opposite-sex prairie vole pairs is modulated by early-life sleep experience.PLoS Biol202641894400PubTator, text miningPubMed
From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.Front Cell Dev Biol202641799440PubTator, text miningPubMed
Metabolic Mechanisms in Electroconvulsive Therapy for Schizophrenia: Role, Potential and Future Directions.Int J Mol Sci202641751887PubTator, text miningPubMed
Genetics and Epigenetics of Obsessive-Compulsive Disorder.Genes (Basel)202641751572PubTator, text miningPubMed

1 to 10 of 1,856

See all 1,856 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/22941

GET https://conductscience.org/api/genes/v1/22941/patents