Gene · 22941
SHANK2: SH3 and multiple ankyrin repeat domains 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SHANK2: SH3 and multiple ankyrin repeat domains 2. Genes, record 22941. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22941
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UPX8 | SH3 and multiple ankyrin repeat domains protein 2 | 1,849 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents13
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 3560 | Q9UPX8 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22159 | Q9UPX8 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3560 | Q9UPX8 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22159 | Q9UPX8 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35633 | Q9UPX8 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35633 | Q9UPX8 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 35633 | Q9UPX8 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78561 | Q9UPX8 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 181532 | Q9UPX8 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10237 | Q9UPX8 | Espacenet |
1 to 10 of 13
See all 13 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,543
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SHANK2 papers | Newest fiscal year |
|---|---|---|---|
| ZIANS003113 | Dynamic Structural Properties of Synapses | 6 | 2025 |
| R01MH071316 | Rac-GEF signaling in dendritic spines | 5 | 2025 |
| R01DK080834 | Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea | 4 | 2025 |
| R01GM121907 | Genomic basis of phenotypic variability of complex disorders | 4 | 2025 |
| R01HD036071 | Genotype-Phenotype Relationships in Fragile X Families | 4 | 2025 |
| R01MH101221 | Rare Mutations and Autism Spectrum Disorders | 4 | 2025 |
| T32HG000035 | Interdisciplinary Training in Genome Sciences | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| R01MH074090 | Gene Dosage Imbalance in Neurodevelopmental Disorders | 3 | 2025 |
1 to 10 of 1,543Source NIH's project files
See all 1,543 nih grantsPapers1,856
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Prenatal Folinic Acid in FRAA-Positive Pregnancies: Preschool Neurodevelopmental Outcomes from a Pilot RCT Follow-Up. | Nutrients | 2026 | 42796952 | PubTator, text mining | PubMed |
| Characterizing features of the genetic architecture underlying autism from a multi-ancestry perspective. | Mol Psychiatry | 2026 | 42728317 | PubTator, text mining | PubMed |
| Prenatal exposure to the plasticizer DEHP increases the likelihood of early-life autism and ADHD symptoms through epigenetic programming. | Med | 2026 | 42727573 | PubTator, text mining | PubMed |
| Frequently amplified SHANK2 promotes esophageal squamous cell carcinoma progression through the DVL/YAP axis. | Oncogene | 2026 | 42675223 | PubTator, text mining | PubMed |
| Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer's and Parkinson's Disease. | Cells | 2026 | 42645161 | PubTator, text mining | PubMed |
| Subcortical Dendritic Scaffolding in Autism Spectrum Disorder: A Testable ANK2-SCN2A-SHANK Framework. | Int J Mol Sci | 2026 | 42450246 | PubTator, text mining | PubMed |
| Social compatibility in opposite-sex prairie vole pairs is modulated by early-life sleep experience. | PLoS Biol | 2026 | 41894400 | PubTator, text mining | PubMed |
| From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders. | Front Cell Dev Biol | 2026 | 41799440 | PubTator, text mining | PubMed |
| Metabolic Mechanisms in Electroconvulsive Therapy for Schizophrenia: Role, Potential and Future Directions. | Int J Mol Sci | 2026 | 41751887 | PubTator, text mining | PubMed |
| Genetics and Epigenetics of Obsessive-Compulsive Disorder. | Genes (Basel) | 2026 | 41751572 | PubTator, text mining | PubMed |
1 to 10 of 1,856
See all 1,856 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/22941
GET https://conductscience.org/api/genes/v1/22941/patents