ConductScience.org, home

Library / Genes

DKK1: dickkopf Wnt signaling pathway inhibitor 1

1 protein, 382 patents, 2 drugs, 15 trials, 4,480 NIH grants and 10,126 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolDKK1HGNC
Namedickkopf Wnt signaling pathway inhibitor 1HGNC
NCBI Gene ID22943NCBI Gene
HGNC IDHGNC:2891HGNC
EnsemblENSG00000107984NCBI Gene
AliasesDKK-1, SKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O94907Dickkopf-related protein 12665Ensembl, GeneID, HGNCUniProt

Patents 382

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026048885 A2026-03-0513O94907Espacenet
WO 2026017877 A12026-01-2226O94907Espacenet
JP 2026004568 A2026-01-1443741O94907Espacenet
EP 4650780 A22025-11-199411O94907Espacenet
JP 2025147176 A2025-10-064248O94907Espacenet
JP 2025529142 A2025-09-046181O94907Espacenet
US 12371689 B22025-07-296181O94907Espacenet
JP 2025517970 A2025-06-129411O94907Espacenet
JP 2025028160 A2025-02-284248O94907Espacenet
KR 1020250010750 A2025-01-214248O94907Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BHQ-880CHEMBL2109381Dickkopf-related protein 1 inhibitorINHIBITORChEMBL
DKN-01CHEMBL4297562Dickkopf-related protein 1 inhibitorINHIBITORChEMBL

Trials 15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05761951DKN-01PHASE2ClinicalTrials.gov
NCT05480306DKN-01PHASE2ClinicalTrials.gov
NCT04363801DKN-01PHASE22025-10-09ClinicalTrials.gov
NCT04057365DKN-01PHASE22024-04-10ClinicalTrials.gov
NCT03837353DKN-01PHASE1/PHASE22023-12-18ClinicalTrials.gov
NCT03818997DKN-01PHASE2ClinicalTrials.gov
NCT03645980DKN-01PHASE1/PHASE2ClinicalTrials.gov
NCT03395080DKN-01PHASE22023-06-09ClinicalTrials.gov
NCT02375880DKN-01PHASE1ClinicalTrials.gov
NCT02013154DKN-01PHASE1ClinicalTrials.gov

NIH grants 4480

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant332,025NIH's project files
P30CA008748Cancer Center Support Grant322,025NIH's project files
P30CA062203Cancer Center Support Grant162,025NIH's project files
P30CA006973Regional Oncology Research Center112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P01CA155258Integrative Oncogenomics of Multiple Myeloma92,025NIH's project files
P30CA016058Cancer Center Support Grant82,025NIH's project files
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling82,025NIH's project files
P20GM125503Center for Musculoskeletal Disease Research (CMDR)72,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease72,025NIH's project files

Papers 10126

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825020PubTator, text miningPubMed
42808424PubTator, text miningPubMed
42807979PubTator, text miningPubMed
42785656PubTator, text miningPubMed
42769034PubTator, text miningPubMed
42765911PubTator, text miningPubMed
42745284PubTator, text miningPubMed
42723851PubTator, text miningPubMed
42722719PubTator, text miningPubMed
42716267PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license