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Gene · 2296

FOXC1: forkhead box C1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FOXC1: forkhead box C1. Genes, record 2296. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2296

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Gene

Symbol
FOXC1
HGNC
Name
forkhead box C1
HGNC
NCBI Gene ID
2296
NCBI Gene
HGNC ID
HGNC:3800
HGNC
Ensembl
ENSG00000054598
NCBI Gene
Aliases
ARA, ASGD3, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12948Forkhead box protein C15530Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446529Q12948Espacenet
EP 4650780 A22025-11-1919373Q12948Espacenet
JP 2025147176 A2025-10-0614978Q12948Espacenet
JP 2025521922 A2025-07-1047Q12948Espacenet
JP 2025517970 A2025-06-1219373Q12948Espacenet
JP 2025028160 A2025-02-2814978Q12948Espacenet
KR 1020250010750 A2025-01-2114978Q12948Espacenet
JP 2024151104 A2024-10-2435Q12948Espacenet
JP 2024109657 A2024-08-1414817Q12948Espacenet
US 12024722 B22024-07-02296Q12948Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,680

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFOXC1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center132025
P30EY014104P30 Core Grant for Vision Research132025
P30CA008748Cancer Center Support Grant102025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics92025
T32EY014537Research Training Program in Vision Science82025
P30EY007003University of Michigan Vision Research Center72025
P30CA068485Cancer Center Support Grant52025
UL1TR001881UCLA Clinical and Translational Science Institute52025
P30CA016086Cancer Center Support Grant42025

1 to 10 of 1,680Source NIH's project files

See all 1,680 nih grants

Papers3,080

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
FOXC1 drives lung cancer metastasis and functions as a target for AI-enabled anti-metastatic drug discovery.Front Pharmacol202642787160PubTator, text miningPubMed
Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations.iScience202642765034PubTator, text miningPubMed
Exome-wide screening discovers novel pathogenic variants in Vietnamese primary congenital glaucoma patients.Genes Genomics202642758422PubTator, text miningPubMed
Genetic Architecture and Clinical Phenotypes of Primary Open-Angle Glaucoma: An Updated Review of Mendelian Genes, GWAS Loci, and Polygenic Risk.Clin Ophthalmol202642751619PubTator, text miningPubMed
TFAP2B and FOXC1 are associated with biologically and clinically distinct differentiation states in triple-negative breast cancer.Sci Rep202642728354PubTator, text miningPubMed
Previously unreported pathogenic variant in FOXC1 causing Axenfeld-Rieger syndrome with significant ocular anterior segment dysgenesis.BMJ Case Rep202642728069PubTator, text miningPubMed
SEI1 complex silences p53 to drive myeloma progression.iScience202642698665PubTator, text miningPubMed
FOXC1 drives pulmonary arterial endothelial cell dysfunction and vascular remodeling through transcriptional activation of MACC1.Free Radic Biol Med202642697341PubTator, text miningPubMed
RNAscope™ In Situ Hybridization for the Detection of a Long Noncoding RNA in an Organ-on-a-Chip.Methods Mol Biol202642681466PubTator, text miningPubMed
Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia.Ophthalmol Sci202642667103PubTator, text miningPubMed

1 to 10 of 3,080

See all 3,080 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2296

GET https://conductscience.org/api/genes/v1/2296/patents?page=2