Gene · 2296
FOXC1: forkhead box C1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FOXC1: forkhead box C1. Genes, record 2296. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2296
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q12948 | Forkhead box protein C1 | 553 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents34
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 46529 | Q12948 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19373 | Q12948 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14978 | Q12948 | Espacenet |
| JP 2025521922 A | 2025-07-10 | 47 | Q12948 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19373 | Q12948 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 14978 | Q12948 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 14978 | Q12948 | Espacenet |
| JP 2024151104 A | 2024-10-24 | 35 | Q12948 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 14817 | Q12948 | Espacenet |
| US 12024722 B2 | 2024-07-02 | 296 | Q12948 | Espacenet |
1 to 10 of 34
See all 34 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,680
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FOXC1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 13 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| R01EY022305 | NEIGHBORHOOD Consortium for POAG Genetics | 9 | 2025 |
| T32EY014537 | Research Training Program in Vision Science | 8 | 2025 |
| P30EY007003 | University of Michigan Vision Research Center | 7 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,680Source NIH's project files
See all 1,680 nih grantsPapers3,080
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| FOXC1 drives lung cancer metastasis and functions as a target for AI-enabled anti-metastatic drug discovery. | Front Pharmacol | 2026 | 42787160 | PubTator, text mining | PubMed |
| Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations. | iScience | 2026 | 42765034 | PubTator, text mining | PubMed |
| Exome-wide screening discovers novel pathogenic variants in Vietnamese primary congenital glaucoma patients. | Genes Genomics | 2026 | 42758422 | PubTator, text mining | PubMed |
| Genetic Architecture and Clinical Phenotypes of Primary Open-Angle Glaucoma: An Updated Review of Mendelian Genes, GWAS Loci, and Polygenic Risk. | Clin Ophthalmol | 2026 | 42751619 | PubTator, text mining | PubMed |
| TFAP2B and FOXC1 are associated with biologically and clinically distinct differentiation states in triple-negative breast cancer. | Sci Rep | 2026 | 42728354 | PubTator, text mining | PubMed |
| Previously unreported pathogenic variant in FOXC1 causing Axenfeld-Rieger syndrome with significant ocular anterior segment dysgenesis. | BMJ Case Rep | 2026 | 42728069 | PubTator, text mining | PubMed |
| SEI1 complex silences p53 to drive myeloma progression. | iScience | 2026 | 42698665 | PubTator, text mining | PubMed |
| FOXC1 drives pulmonary arterial endothelial cell dysfunction and vascular remodeling through transcriptional activation of MACC1. | Free Radic Biol Med | 2026 | 42697341 | PubTator, text mining | PubMed |
| RNAscope™ In Situ Hybridization for the Detection of a Long Noncoding RNA in an Organ-on-a-Chip. | Methods Mol Biol | 2026 | 42681466 | PubTator, text mining | PubMed |
| Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia. | Ophthalmol Sci | 2026 | 42667103 | PubTator, text mining | PubMed |
1 to 10 of 3,080
See all 3,080 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2296
GET https://conductscience.org/api/genes/v1/2296/patents?page=2