Gene · 22974
TPX2: TPX2 microtubule nucleation factor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TPX2: TPX2 microtubule nucleation factor. Genes, record 22974. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22974
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9ULW0 | Targeting protein for Xklp2 | 747 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents65
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4002 | Q9ULW0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3581 | Q9ULW0 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4763 | Q9ULW0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3581 | Q9ULW0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4002 | Q9ULW0 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4763 | Q9ULW0 | Espacenet |
| US 12006548 B2 | 2024-06-11 | 547 | Q9ULW0 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1159 | Q9ULW0 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5201 | Q9ULW0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89343 | Q9ULW0 | Espacenet |
1 to 10 of 65
See all 65 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,222
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TPX2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 10 | 2025 |
| R01GM141100 | Role and Mechanisms of Microtubule Nucleation in Spindle Assembly | 6 | 2025 |
| R35GM119455 | Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases | 6 | 2025 |
| T32CA119925 | Integrated Biological Systems Training in Oncology | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 5 | 2025 |
1 to 10 of 1,222Source NIH's project files
See all 1,222 nih grantsPapers2,543
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization. | Cell Rep | 2026 | 42789387 | PubTator, text mining | PubMed |
| Divergent microtubule-organizing center strategies in mammalian gametogenesis. | Trends Open | 2026 | 42761981 | PubTator, text mining | PubMed |
| Light-induced spindle assembly through Aurora A clustering. | EMBO Rep | 2026 | 42744924 | PubTator, text mining | PubMed |
| TvTPPIMI: A Boundary-Aware Dual-View Framework for Predicting PPI-Modulator Interactions. | J Chem Inf Model | 2026 | 42734552 | PubTator, text mining | PubMed |
| Identification of functional genes and immune cell infiltration analysis in liposarcoma. | PLoS One | 2026 | 42726806 | PubTator, text mining | PubMed |
| CircLDLR silencing alleviates the damage of keratinocytes induced by M5 cytokine via the miR-1294/TPX2 axis. | Tissue Cell | 2026 | 42594498 | PubTator, text mining | PubMed |
| Mitotic Hub Gene Network in Colorectal Cancer: Integrated Transcriptomic, Protein-Level, and Clinical-Genomic Characterization of a Ten-Gene Signature. | Genes (Basel) | 2026 | 42510823 | PubTator, text mining | PubMed |
| HURP Silencing Differentially Impacts Spindle Architecture and Metastatic Behavior in Breast Cancer Cell Lines. | Int J Mol Sci | 2026 | 42450166 | PubTator, text mining | PubMed |
| SPP1+ Macrophages Promote Immunosuppression in Post-TACE Hepatocellular Carcinoma Involving Lactate-Induced Lactylation and Potential SPP1-CD44 Signaling. | J Hepatocell Carcinoma | 2026 | 42438784 | PubTator, text mining | PubMed |
| Single-cell and bulk transcriptomics identify senescence-related EMT transcriptional programs and a prognostic framework in pancreatic ductal adenocarcinoma. | BMC Gastroenterol | 2026 | 42420840 | PubTator, text mining | PubMed |
1 to 10 of 2,543
See all 2,543 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/22974
GET https://conductscience.org/api/genes/v1/22974/patents?page=2