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Gene · 22974

TPX2: TPX2 microtubule nucleation factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPX2: TPX2 microtubule nucleation factor. Genes, record 22974. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/22974

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Gene

Symbol
TPX2
HGNC
Name
TPX2 microtubule nucleation factor
HGNC
NCBI Gene ID
22974
NCBI Gene
HGNC ID
HGNC:1249
HGNC
Ensembl
ENSG00000088325
NCBI Gene
Aliases
C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9ULW0Targeting protein for Xklp274714Ensembl, GeneID, HGNC

Source UniProt

Patents65

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194002Q9ULW0Espacenet
EP 4641201 A22025-10-293581Q9ULW0Espacenet
EP 4641202 A22025-10-294763Q9ULW0Espacenet
JP 2025517969 A2025-06-123581Q9ULW0Espacenet
JP 2025517970 A2025-06-124002Q9ULW0Espacenet
KR 1020250017231 A2025-02-044763Q9ULW0Espacenet
US 12006548 B22024-06-11547Q9ULW0Espacenet
US 11860162 B22024-01-021159Q9ULW0Espacenet
US 11564998 B22023-01-315201Q9ULW0Espacenet
US 11446398 B22022-09-2089343Q9ULW0Espacenet

1 to 10 of 65

See all 65 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,222

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPX2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA006927Comprehensive Cancer Center Program at Fox Chase102025
R01GM141100Role and Mechanisms of Microtubule Nucleation in Spindle Assembly62025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases62025
T32CA119925Integrated Biological Systems Training in Oncology62025
P30CA008748Cancer Center Support Grant52025
P30CA023108Cancer Center Support Grant52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA068485Cancer Center Support Grant52025
P50CA097186The Pacific Northwest Prostate Cancer SPORE52025

1 to 10 of 1,222Source NIH's project files

See all 1,222 nih grants

Papers2,543

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization.Cell Rep202642789387PubTator, text miningPubMed
Divergent microtubule-organizing center strategies in mammalian gametogenesis.Trends Open202642761981PubTator, text miningPubMed
Light-induced spindle assembly through Aurora A clustering.EMBO Rep202642744924PubTator, text miningPubMed
TvTPPIMI: A Boundary-Aware Dual-View Framework for Predicting PPI-Modulator Interactions.J Chem Inf Model202642734552PubTator, text miningPubMed
Identification of functional genes and immune cell infiltration analysis in liposarcoma.PLoS One202642726806PubTator, text miningPubMed
CircLDLR silencing alleviates the damage of keratinocytes induced by M5 cytokine via the miR-1294/TPX2 axis.Tissue Cell202642594498PubTator, text miningPubMed
Mitotic Hub Gene Network in Colorectal Cancer: Integrated Transcriptomic, Protein-Level, and Clinical-Genomic Characterization of a Ten-Gene Signature.Genes (Basel)202642510823PubTator, text miningPubMed
HURP Silencing Differentially Impacts Spindle Architecture and Metastatic Behavior in Breast Cancer Cell Lines.Int J Mol Sci202642450166PubTator, text miningPubMed
SPP1+ Macrophages Promote Immunosuppression in Post-TACE Hepatocellular Carcinoma Involving Lactate-Induced Lactylation and Potential SPP1-CD44 Signaling.J Hepatocell Carcinoma202642438784PubTator, text miningPubMed
Single-cell and bulk transcriptomics identify senescence-related EMT transcriptional programs and a prognostic framework in pancreatic ductal adenocarcinoma.BMC Gastroenterol202642420840PubTator, text miningPubMed

1 to 10 of 2,543

See all 2,543 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/22974

GET https://conductscience.org/api/genes/v1/22974/patents?page=2