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Gene · 2303

FOXC2: forkhead box C2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FOXC2: forkhead box C2. Genes, record 2303. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2303

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Gene

Symbol
FOXC2
HGNC
Name
forkhead box C2
HGNC
NCBI Gene ID
2303
NCBI Gene
HGNC ID
HGNC:3801
HGNC
Ensembl
ENSG00000176692
NCBI Gene
Aliases
FKHL14, LD, MFH-1, MFH1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99958Forkhead box protein C25016Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1919650Q99958Espacenet
JP 2025147176 A2025-10-0614979Q99958Espacenet
JP 2025521922 A2025-07-1048Q99958Espacenet
JP 2025517970 A2025-06-1219650Q99958Espacenet
JP 2025028160 A2025-02-2814979Q99958Espacenet
KR 1020250010750 A2025-01-2114979Q99958Espacenet
JP 2024123008 A2024-09-106285Q99958Espacenet
JP 2024109657 A2024-08-1414818Q99958Espacenet
US 12024722 B22024-07-02297Q99958Espacenet
JP 2024506208 A2024-02-0996Q99958Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,592

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFOXC2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant292025
R01HL131652Defining the Mechanisms of Lymphatic Vascular Growth and Function72025
R01HL133216Molecular Mechanisms Controlling Lymphatic Vascular Function in Health and Disease72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30CA008748Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA056036Translational Research in Cancer42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P30EY007003University of Michigan Vision Research Center42025

1 to 10 of 1,592Source NIH's project files

See all 1,592 nih grants

Papers2,402

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SCTR-Expressing Astrocyte-Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac-Foxc2 Epigenetic Axis in an AMPK-Dependent Manner.Adv Sci (Weinh)202642801528PubTator, text miningPubMed
Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Curr Issues Mol Biol202642793248PubTator, text miningPubMed
Engineering lymphatic collecting vessel phenotypes through combined hyaluronic acid cues and oscillatory shear stress.Cell Rep Methods202642697195PubTator, text miningPubMed
Transcriptomic profiling of thyroid eye disease orbital fibroblasts identifies sorafenib as a novel therapeutic.Front Endocrinol (Lausanne)202642688036PubTator, text miningPubMed
Restoration of oscillatory shear stress in humans activates an endothelial protective genetic program and prevents DVT.Blood202642611796PubTator, text miningPubMed
Yellow Nail Syndrome in Childhood: A Case Report Highlighting Diagnostic Challenges and the Possible Role of Nail Development-Related Genetic Variants.Skin Appendage Disord202642610102PubTator, text miningPubMed
Out"FOX"ing cancer: the implications of FOXC2 as a putative predictive biomarker for cancer immunotherapy.Front Med (Lausanne)202642454125PubTator, text miningPubMed
Procr+ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals.Blood202642101967PubTator, text miningPubMed
The role of the cardiac lymphatic system in heart failure "reverse remodeling": from developmental signals to druggable targets.Front Immunol202642099625PubTator, text miningPubMed
FOXC2 represses NFAT1-dependent transcription through a DNA-facilitated protein-protein interaction.Nucleic Acids Res202642023653PubTator, text miningPubMed

1 to 10 of 2,402

See all 2,402 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2303

GET https://conductscience.org/api/genes/v1/2303/patents?page=2