Gene · 23049
SMG1: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMG1: SMG1 nonsense mediated mRNA decay associated PI3K related kinase. Genes, record 23049. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23049
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96Q15 | Serine/threonine-protein kinase SMG1 | 3,661 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63825 | Q96Q15 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 14891 | Q96Q15 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 14891 | Q96Q15 | Espacenet |
| US 12275764 B2 | 2025-04-15 | 8 | Q96Q15 | Espacenet |
| JP 2024509935 A | 2024-03-05 | 85 | Q96Q15 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 210 | Q96Q15 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80042 | Q96Q15 | Espacenet |
| US 11332504 B2 | 2022-05-17 | 8 | Q96Q15 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183013 | Q96Q15 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10691 | Q96Q15 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,515
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMG1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 6 | 2025 |
| P30DK072482 | UAB CF Research and Translation Core Center | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| ZIAHL006158 | Mechanisms of nonsense-mediated mRNA decay target selection | 4 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 3 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 3 | 2025 |
| P30CA082103 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,515Source NIH's project files
See all 1,515 nih grantsPapers2,633
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The transcription factor C/EBPβ promotes hyperglycemia-elicited glycolysis and liver cancer progression. | Nat Commun | 2026 | 42722647 | PubTator, text mining | PubMed |
| Integrated LiP-MS and quantitative proteomics reveal coordinated alterations in protein conformation and expression across tumor and peritumoral regions in hepatocellular carcinoma. | Sci Rep | 2026 | 42686792 | PubTator, text mining | PubMed |
| Degradation of a graphene-reinforced polyamide by fungi: When culture conditions matter. | J Environ Sci (China) | 2026 | 42680386 | PubTator, text mining | PubMed |
| Cell cycle-dependent translation-mediated turnover of the long noncoding RNA Malat1. | J Cell Biol | 2026 | 42640252 | PubTator, text mining | PubMed |
| Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer. | Front Syst Biol | 2026 | 42630458 | PubTator, text mining | PubMed |
| Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance. | Drug Resist Updat | 2026 | 42556029 | PubTator, text mining | PubMed |
| Global Framework for Lip Product Safety: A Review of the Regulatory Blind Spot in the Modern Market. | Integr Environ Assess Manag | 2026 | 42552978 | PubTator, text mining | PubMed |
| Induction and propagation of ferroptosis evasion by FTH1P7 drives sorafenib resistance in hepatocellular carcinoma. | Eur J Pharmacol | 2026 | 42546831 | PubTator, text mining | PubMed |
| Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress. | Signal Transduct Target Ther | 2026 | 42543384 | PubTator, text mining | PubMed |
| SMG1 in hepatocellular carcinoma: A context-dependent tumor suppressor and a targetable node for NMD-directed immunotherapy. | Crit Rev Oncol Hematol | 2026 | 42537828 | PubTator, text mining | PubMed |
1 to 10 of 2,633
See all 2,633 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23049
GET https://conductscience.org/api/genes/v1/23049/patents?page=2