ConductScience.org, home

Gene · 23049

SMG1: SMG1 nonsense mediated mRNA decay associated PI3K related kinase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SMG1: SMG1 nonsense mediated mRNA decay associated PI3K related kinase. Genes, record 23049. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23049

On this page

Gene

Symbol
SMG1
HGNC
Name
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
HGNC
NCBI Gene ID
23049
NCBI Gene
HGNC ID
HGNC:30045
HGNC
Ensembl
ENSG00000157106
NCBI Gene
Aliases
61E3.4, ATX, KIAA0421, LIP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96Q15Serine/threonine-protein kinase SMG13,66110Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463825Q96Q15Espacenet
EP 4641201 A22025-10-2914891Q96Q15Espacenet
JP 2025517969 A2025-06-1214891Q96Q15Espacenet
US 12275764 B22025-04-158Q96Q15Espacenet
JP 2024509935 A2024-03-0585Q96Q15Espacenet
JP 2022141755 A2022-09-29210Q96Q15Espacenet
US 11446398 B22022-09-2080042Q96Q15Espacenet
US 11332504 B22022-05-178Q96Q15Espacenet
JP 2022524081 A2022-04-27183013Q96Q15Espacenet
US 11078247 B22021-08-0310691Q96Q15Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,515

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMG1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant72025
P40OD010440Caenorhabditis Genetics Center62025
P30DK072482UAB CF Research and Translation Core Center52025
P30CA006973Regional Oncology Research Center42025
ZIAHL006158Mechanisms of nonsense-mediated mRNA decay target selection42025
P30CA014051Cancer Center Support (Core) Grant32025
P30CA015704Cancer Center Support Grant32025
P30CA045508CSHL Cancer Center Support Grant32025
P30CA082103Cancer Center Support Grant32025

1 to 10 of 1,515Source NIH's project files

See all 1,515 nih grants

Papers2,633

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The transcription factor C/EBPβ promotes hyperglycemia-elicited glycolysis and liver cancer progression.Nat Commun202642722647PubTator, text miningPubMed
Integrated LiP-MS and quantitative proteomics reveal coordinated alterations in protein conformation and expression across tumor and peritumoral regions in hepatocellular carcinoma.Sci Rep202642686792PubTator, text miningPubMed
Degradation of a graphene-reinforced polyamide by fungi: When culture conditions matter.J Environ Sci (China)202642680386PubTator, text miningPubMed
Cell cycle-dependent translation-mediated turnover of the long noncoding RNA Malat1.J Cell Biol202642640252PubTator, text miningPubMed
Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer.Front Syst Biol202642630458PubTator, text miningPubMed
Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance.Drug Resist Updat202642556029PubTator, text miningPubMed
Global Framework for Lip Product Safety: A Review of the Regulatory Blind Spot in the Modern Market.Integr Environ Assess Manag202642552978PubTator, text miningPubMed
Induction and propagation of ferroptosis evasion by FTH1P7 drives sorafenib resistance in hepatocellular carcinoma.Eur J Pharmacol202642546831PubTator, text miningPubMed
Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress.Signal Transduct Target Ther202642543384PubTator, text miningPubMed
SMG1 in hepatocellular carcinoma: A context-dependent tumor suppressor and a targetable node for NMD-directed immunotherapy.Crit Rev Oncol Hematol202642537828PubTator, text miningPubMed

1 to 10 of 2,633

See all 2,633 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23049

GET https://conductscience.org/api/genes/v1/23049/patents?page=2