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Gene · 23064

SETX: senataxin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SETX: senataxin. Genes, record 23064. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23064

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Gene

Symbol
SETX
HGNC
Name
senataxin
HGNC
NCBI Gene ID
23064
NCBI Gene
HGNC ID
HGNC:445
HGNC
Ensembl
ENSG00000107290
NCBI Gene
Aliases
ALS4, AOA2, KIAA0625, SCAN2, SCAR1, STEX, Sen1, bA479K20.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q7Z333Helicase senataxin2,6770Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462936Q7Z333Espacenet
EP 4650780 A22025-11-19609Q7Z333Espacenet
EP 4641201 A22025-10-29427Q7Z333Espacenet
JP 2025111747 A2025-07-30135Q7Z333Espacenet
JP 2025517969 A2025-06-12427Q7Z333Espacenet
JP 2025517970 A2025-06-12609Q7Z333Espacenet
US 11597924 B22023-03-07103Q7Z333Espacenet
JP 2022141755 A2022-09-29175Q7Z333Espacenet
US 11446398 B22022-09-2077381Q7Z333Espacenet
JP 2022524081 A2022-04-27180352Q7Z333Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,026

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSETX papersNewest fiscal year
R35GM118136Regulation of mRNA processing: Mechanisms and Consequences82025
P01CA092584Structural Cell Biology of DNA Repair Machines72025
P30CA054174Mays Cancer Center at UT Health SA72025
R01GM119334Mechanisms of R-loop-Associated Genome Instability72025
ZIAAG000933Genetic etiology of Amyotrophic Lateral Sclerosis72025
R01AI099195Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic Hypermutation52025
R35CA241801Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression52025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center42025
R01NS115834The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.42025
ZIAAG000934ALZHEIMERS RESEARCH PROJECT: Genetic etiology of Fronto-Temporal Dementia, a dementia related to Alzheimer's disease42025

1 to 10 of 1,026Source NIH's project files

See all 1,026 nih grants

Papers1,471

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Convergent TBK1 loss of function drives gasdermin E dependent pyroptosis and motor neuron degeneration across ALS genotypes.Cell Death Differ202642768102PubTator, text miningPubMed
Ataxia with oculomotor apraxia type 2 due to the new compound heterozygous variants c.5825T>C (inherited) and c.6106+1G>T (de novo) in SETX.Clinics (Sao Paulo)202642715900PubTator, text miningPubMed
The DNA/RNA Helicase SETX Maintains R-Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer.Cancer Sci202642713672PubTator, text miningPubMed
Genetic profile of motor neuron disease in a multiregional Brazilian cohort: an 18-year real-world experience in 1,911 patients.Front Neurol202642621206PubTator, text miningPubMed
R-loops: Biological functions, regulatory mechanisms, and therapeutic implications in brain diseases-A review.Mol Cell Probes202642508540PubTator, text miningPubMed
General anaesthesia for laparoscopic cholecystectomy in a patient with ataxia with oculomotor apraxia type 2.Anaesth Rep202642459760PubTator, text miningPubMed
The genetic landscape of childhood-onset dystonia in a nationwide Turkish cohort: Clinical spectrum, molecular diagnostics, and therapeutic implications.Eur J Paediatr Neurol202642308683PubTator, text miningPubMed
Genomic Landscape and Phenotypic Spectrum of Autosomal Recessive Cerebellar Ataxia in China.Mov Disord202642243046PubTator, text miningPubMed
Unraveling the Pathophysiological Link Between ALS and SCA: The Role of Ischemic Cerebral Vascular Dissection and the Efficacy of Endovascular Therapy.Cerebellum202642081010PubTator, text miningPubMed
Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex.Nat Struct Mol Biol202641917467PubTator, text miningPubMed

1 to 10 of 1,471

See all 1,471 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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