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FOXO3: forkhead box O3

1 protein, 78 patents, 0 drugs, 0 trials, 7,320 NIH grants and 17,015 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFOXO3HGNC
Nameforkhead box O3HGNC
NCBI Gene ID2309NCBI Gene
HGNC IDHGNC:3821HGNC
EnsemblENSG00000118689NCBI Gene
AliasesAF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3ANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O43524Forkhead box protein O36737Ensembl, GeneID, HGNCUniProt

Patents 78

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026015647 A12026-01-15200O43524Espacenet
EP 4650780 A22025-11-196443O43524Espacenet
WO 2025235563 A12025-11-1325O43524Espacenet
WO 2025231400 A12025-11-063O43524Espacenet
JP 2025147176 A2025-10-0615011O43524Espacenet
JP 2025517970 A2025-06-126443O43524Espacenet
WO 2025059073 A12025-03-20233O43524Espacenet
JP 2025028160 A2025-02-2815011O43524Espacenet
WO 2025038494 A12025-02-20136O43524Espacenet
WO 2025029835 A12025-02-06219O43524Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7320

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1332,025NIH's project files
P30CA008748Cancer Center Support Grant482,025NIH's project files
R01AG027060First Comprehensive Mitochondrial DNA Brain Mutation Atlas for Alzheimer's Disease282,025NIH's project files
P30CA016058Cancer Center Support Grant232,025NIH's project files
U19AG023122Longevity Consortium202,025NIH's project files
P40OD010440Caenorhabditis Genetics Center182,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)162,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center162,025NIH's project files
P30CA047904Cancer Center Support Grant152,025NIH's project files
P30CA068485Cancer Center Support Grant152,025NIH's project files

Papers 17015

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816692PubTator, text miningPubMed
42816254PubTator, text miningPubMed
42797505PubTator, text miningPubMed
42795268PubTator, text miningPubMed
42790898PubTator, text miningPubMed
42785059PubTator, text miningPubMed
42781926PubTator, text miningPubMed
42781311PubTator, text miningPubMed
42778761PubTator, text miningPubMed
42773333PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license