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AKR1B1: aldo-keto reductase family 1 member B

1 protein, 40 patents, 4 drugs, 7 trials, 2,316 NIH grants and 6,603 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAKR1B1HGNC
Namealdo-keto reductase family 1 member BHGNC
NCBI Gene ID231NCBI Gene
HGNC IDHGNC:381HGNC
EnsemblENSG00000085662NCBI Gene
AliasesADR, ALDR1, ALR2, ARNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P15121Aldo-keto reductase family 1 member B1316177Ensembl, GeneID, HGNCUniProt

Patents 40

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437060P15121Espacenet
EP 4650780 A22025-11-193273P15121Espacenet
JP 2025517970 A2025-06-123273P15121Espacenet
JP 2025062604 A2025-04-143958P15121Espacenet
JP 2025038035 A2025-03-184426P15121Espacenet
US 12134655 B22024-11-054426P15121Espacenet
US 11446398 B22022-09-203958P15121Espacenet
JP 2022530667 A2022-06-304426P15121Espacenet
JP 2022524081 A2022-04-27106929P15121Espacenet
US 11078247 B22021-08-03408P15121Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAFICRESTATCHEMBL4297455Aldose reductase inhibitorINHIBITORChEMBL
EPALRESTATCHEMBL56337Aldose reductase inhibitorINHIBITORChEMBL
SORBINILCHEMBL266497Aldose reductase inhibitorINHIBITORChEMBL
TOLRESTATCHEMBL436Aldose reductase inhibitorINHIBITORChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07557914EPALRESTATPHASE2ClinicalTrials.gov
NCT06201611EPALRESTATPHASE2/PHASE3ClinicalTrials.gov
NCT05777226EPALRESTATPHASE2ClinicalTrials.gov
NCT04365699CAFICRESTATPHASE22021-09-16ClinicalTrials.gov
NCT04083339CAFICRESTATPHASE3ClinicalTrials.gov
NCT03244358EPALRESTATPHASE2ClinicalTrials.gov
NCT01731093CAFICRESTATPHASE1ClinicalTrials.gov

NIH grants 2316

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30ES013508Center of Excellence in Environmental Toxicology172,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center112,025NIH's project files
P30CA008748Cancer Center Support Grant82,025NIH's project files
P30CA016672Cancer Center Support Grant72,025NIH's project files
R01CA070297New Insight of Androgen Signaling in Prostate Cancer Initiation and Progression72,025NIH's project files
P30CA006973Regional Oncology Research Center62,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)62,025NIH's project files
P30DK036836Diabetes Research Center62,025NIH's project files
ZIANS003034Biomarkers of Catecholaminergic Neurodegeneration62,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52,025NIH's project files

Papers 6603

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823960PubTator, text miningPubMed
42822613PubTator, text miningPubMed
42790823PubTator, text miningPubMed
42737538PubTator, text miningPubMed
42736664PubTator, text miningPubMed
42715652PubTator, text miningPubMed
42712219PubTator, text miningPubMed
42689952PubTator, text miningPubMed
42675099PubTator, text miningPubMed
42654113PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license