Gene · 23135
KDM6B: lysine demethylase 6B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KDM6B: lysine demethylase 6B. Genes, record 23135. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23135
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15054 | Lysine-specific demethylase 6B | 1,643 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52118 | O15054 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15892 | O15054 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 6825 | O15054 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15892 | O15054 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 6825 | O15054 | Espacenet |
| US 12178854 B2 | 2024-12-31 | 6 | O15054 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 311 | O15054 | Espacenet |
| JP 2023052678 A | 2023-04-11 | 2 | O15054 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 47775 | O15054 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 150746 | O15054 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,256
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KDM6B papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 22 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 7 | 2025 |
| R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 7 | 2025 |
| ZIADK075003 | Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 5 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 2,256Source NIH's project files
See all 2,256 nih grantsPapers3,078
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential. | Front Clin Diabetes Healthc | 2026 | 42757034 | PubTator, text mining | PubMed |
| KDM6B inhibition modulates monocyte activation and alleviates IMQ-induced psoriasis-like skin inflammation. | Cell Commun Signal | 2026 | 42732058 | PubTator, text mining | PubMed |
| Corrigendum to "Glutamine alleviates lead-induced neuroinflammation via αKG-JMJD3-H3K27me3 pathway: Population, animal, and in vitro evidence" [Ecotoxicol. Environ. Saf. 323 (2026) 120721]. | Ecotoxicol Environ Saf | 2026 | 42722590 | PubTator, text mining | PubMed |
| JMJD3-mediated HADH demethylation orchestrates hepatocyte maturation through fatty acid β-oxidation-dependent histone acetylation. | Exp Mol Med | 2026 | 42680802 | PubTator, text mining | PubMed |
| Palmitic Acid Amplifies Microglial Inflammatory Activation Involving C5aR1-Sensitive Inflammatory Signaling and JMJD3/H3K27me3-Related Epigenetic Changes. | J Neuroimmune Pharmacol | 2026 | 42645696 | PubTator, text mining | PubMed |
| Epigenetic Activation of the KDM6B-DKK1 Axis Promotes Colorectal Cancer Peritoneal Metastasis Through Wnt/β-Catenin-Associated EMT. | J Cell Mol Med | 2026 | 42634209 | PubTator, text mining | PubMed |
| The KDM6 histone H3K27me3 demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells. | RSC Chem Biol | 2026 | 42597942 | PubTator, text mining | PubMed |
| Pan-cancer multi-omics machine learning defines a lactylation-associated immune-excluded tumor state with proteomic and experimental corroboration. | Comput Biol Chem | 2026 | 42556016 | PubTator, text mining | PubMed |
| Beyond Histone Demethylation: Mechanisms of N‑Alkyl Consecutive Oxidations by the Non-Heme Fe(II)/2-Oxoglutarate Oxygenase KDM6B. | JACS Au | 2026 | 42529351 | PubTator, text mining | PubMed |
| Integrated Transcriptomic Analysis Identifies Potential Biomarkers in Castration-Resistant Prostate Cancer. | World J Oncol | 2026 | 42490773 | PubTator, text mining | PubMed |
1 to 10 of 3,078
See all 3,078 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/23135
GET https://conductscience.org/api/genes/v1/23135/patents?page=2