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Gene · 23135

KDM6B: lysine demethylase 6B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KDM6B: lysine demethylase 6B. Genes, record 23135. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23135

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Gene

Symbol
KDM6B
HGNC
Name
lysine demethylase 6B
HGNC
NCBI Gene ID
23135
NCBI Gene
HGNC ID
HGNC:29012
HGNC
Ensembl
ENSG00000132510
NCBI Gene
Aliases
JMJD3, KIAA0346, NEDCFSA, NEDSST
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15054Lysine-specific demethylase 6B1,6436Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452118O15054Espacenet
EP 4641201 A22025-10-2915892O15054Espacenet
EP 4641202 A22025-10-296825O15054Espacenet
JP 2025517969 A2025-06-1215892O15054Espacenet
KR 1020250017231 A2025-02-046825O15054Espacenet
US 12178854 B22024-12-316O15054Espacenet
JP 2023123507 A2023-09-05311O15054Espacenet
JP 2023052678 A2023-04-112O15054Espacenet
US 11446398 B22022-09-2047775O15054Espacenet
JP 2022524081 A2022-04-27150746O15054Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,256

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKDM6B papersNewest fiscal year
P30CA008748Cancer Center Support Grant222025
P30CA016672Cancer Center Support Grant142025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma72025
ZIADK075003Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN52025
P30CA016058Cancer Center Support Grant52025
P30CA016359Cancer Center Support Grant52025
P30CA033572Cancer Center Support Grant52025

1 to 10 of 2,256Source NIH's project files

See all 2,256 nih grants

Papers3,078

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential.Front Clin Diabetes Healthc202642757034PubTator, text miningPubMed
KDM6B inhibition modulates monocyte activation and alleviates IMQ-induced psoriasis-like skin inflammation.Cell Commun Signal202642732058PubTator, text miningPubMed
Corrigendum to "Glutamine alleviates lead-induced neuroinflammation via αKG-JMJD3-H3K27me3 pathway: Population, animal, and in vitro evidence" [Ecotoxicol. Environ. Saf. 323 (2026) 120721].Ecotoxicol Environ Saf202642722590PubTator, text miningPubMed
JMJD3-mediated HADH demethylation orchestrates hepatocyte maturation through fatty acid β-oxidation-dependent histone acetylation.Exp Mol Med202642680802PubTator, text miningPubMed
Palmitic Acid Amplifies Microglial Inflammatory Activation Involving C5aR1-Sensitive Inflammatory Signaling and JMJD3/H3K27me3-Related Epigenetic Changes.J Neuroimmune Pharmacol202642645696PubTator, text miningPubMed
Epigenetic Activation of the KDM6B-DKK1 Axis Promotes Colorectal Cancer Peritoneal Metastasis Through Wnt/β-Catenin-Associated EMT.J Cell Mol Med202642634209PubTator, text miningPubMed
The KDM6 histone H3K27me3 demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells.RSC Chem Biol202642597942PubTator, text miningPubMed
Pan-cancer multi-omics machine learning defines a lactylation-associated immune-excluded tumor state with proteomic and experimental corroboration.Comput Biol Chem202642556016PubTator, text miningPubMed
Beyond Histone Demethylation: Mechanisms of N‑Alkyl Consecutive Oxidations by the Non-Heme Fe(II)/2-Oxoglutarate Oxygenase KDM6B.JACS Au202642529351PubTator, text miningPubMed
Integrated Transcriptomic Analysis Identifies Potential Biomarkers in Castration-Resistant Prostate Cancer.World J Oncol202642490773PubTator, text miningPubMed

1 to 10 of 3,078

See all 3,078 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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