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Gene · 23175

LPIN1: lipin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LPIN1: lipin 1. Genes, record 23175. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23175

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Gene

Symbol
LPIN1
HGNC
Name
lipin 1
HGNC
NCBI Gene ID
23175
NCBI Gene
HGNC ID
HGNC:13345
HGNC
Ensembl
ENSG00000134324
NCBI Gene
Aliases
KIAA0188, PAP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14693Phosphatidate phosphatase LPIN18900Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451840Q14693Espacenet
EP 4650780 A22025-11-191602Q14693Espacenet
EP 4641201 A22025-10-291210Q14693Espacenet
JP 2025517969 A2025-06-121210Q14693Espacenet
JP 2025517970 A2025-06-121602Q14693Espacenet
US 11446398 B22022-09-2047007Q14693Espacenet
JP 2022524081 A2022-04-27149978Q14693Espacenet
KR 1020210128370 A2021-10-2622Q14693Espacenet
US 11020429 B22021-06-0124Q14693Espacenet
US 10881746 B22021-01-051Q14693Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,295

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLPIN1 papersNewest fiscal year
P30DK056341Washington University Nutrition Obesity Research Center202025
P30DK020579Diabetes Research Center102025
T32HG002536Training Grant in Genomic Analysis and Interpretation92025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease72025
P30CA016058Cancer Center Support Grant52025
R35GM136128Regulation and Role of Phosphatidate Phosphatase in Lipid Metabolism52025
U01DK061734Clinical Research on Nonalcoholic Fatty Liver Disease52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P50AA024333Alcohol and tissue injury, from mechanisms to treatments42025

1 to 10 of 1,295Source NIH's project files

See all 1,295 nih grants

Papers1,577

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Large-Scale Cellular Phosphoproteomic Analysis Reveals a Putative Role for LPIN1 S162 in Metabolic Signaling.OMICS202642657976PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Early identification of LPIN1 variant in a child with severe myoglobinuria and a history of sibling deaths.CEN Case Rep202642545443PubTator, text miningPubMed
Unveiling the dynamic transcriptomic changes in and replicative senescence balance of hUC-MSCs: A comparative study of serum-containing versus serum-free culture supplements.Tissue Cell202642537251PubTator, text miningPubMed
Role of Lipin-1 in Macrophage-Mediated Atherosclerosis: Is It Atherogenic or Atheroprotective?J Am Heart Assoc202642535557PubTator, text miningPubMed
Copper induces depressive-like behavior through neuronal lipid accumulation mediated by Lipin-1.Neurotoxicology202642442639PubTator, text miningPubMed
Fatty acid metabolism and lipid channeling in macrophages: mechanisms of inflammation, resolution, and lipotoxicity.Front Immunol202642367816PubTator, text miningPubMed
When Dark Urine Is Not Nephritis: A Life-Threatening Case of Lipin-1 Deficiency in Infancy.Cureus202642220764PubTator, text miningPubMed
Ursocholic acid ameliorates hepatic steatosis via direct AMPK activation in preclinical models of MASLD.Eur J Pharmacol202642128193PubTator, text miningPubMed
Dynamic Role of Omega-3/Omega-6 Polyunsaturated Fatty Acid Ratio in Modulation of Adipogenicity, Lipid Metabolites, and Adipokines Associated with Platelet Hyperactivity.Metabolites202642042916PubTator, text miningPubMed

1 to 10 of 1,577

See all 1,577 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23175

GET https://conductscience.org/api/genes/v1/23175/patents?page=2