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Gene · 2318

FLNC: filamin C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FLNC: filamin C. Genes, record 2318. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2318

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Gene

Symbol
FLNC
HGNC
Name
filamin C
HGNC
NCBI Gene ID
2318
NCBI Gene
HGNC ID
HGNC:3756
HGNC
Ensembl
ENSG00000128591
NCBI Gene
Aliases
ABP-280, ABP280A, ABPA, ABPL, ARVC15, CMD1PP, CMH26, FLN2, MFM5, MPD4, RCM5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14315Filamin-C2,72514Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446361Q14315Espacenet
EP 4650780 A22025-11-195708Q14315Espacenet
EP 4640849 A22025-10-29821Q14315Espacenet
EP 4641201 A22025-10-295362Q14315Espacenet
JP 2025519096 A2025-06-24821Q14315Espacenet
JP 2025517969 A2025-06-125362Q14315Espacenet
JP 2025517970 A2025-06-125708Q14315Espacenet
US 11694765 B22023-07-04368Q14315Espacenet
JP 2022141755 A2022-09-29190Q14315Espacenet
US 11446398 B22022-09-2032170Q14315Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,170

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFLNC papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30EY005722Center Core Grant for Vision Research52025
P40OD010440Caenorhabditis Genetics Center52025
R01AR068797Chaperone Dysfunction in Myopathy: Connecting Yeast Genetics with Mouse Models52025
P30CA016086Cancer Center Support Grant42025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant42025
P50HD027802Differential Diagnosis in Learning Disabilities42025
R01AG031867Protein aggregation in inclusion body and myofibrillar myopathies42025

1 to 10 of 2,170Source NIH's project files

See all 2,170 nih grants

Papers3,704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cutaneous ultrastructure reveals potential biomarkers of ventricular arrhythmias in inflammatory cardiomyopathy.Ultrastruct Pathol202642827311PubTator, text miningPubMed
Cardiologist-Delivered Genetic Testing in 482 Patients With Cardiomyopathy: The Infrastructure Needed for Mainstream Testing at Scale.Circ Genom Precis Med202642825316PubTator, text miningPubMed
FLNC-Related Cardiomyopathies in an Admixed Population: Expanding the Genotype-Phenotype Spectrum and Clinical Correlates.Circ Genom Precis Med202642825315PubTator, text miningPubMed
The Multifaceted Role of the FLNC Gene in Hereditary Cardiomyopathies and Prognosis.Genes (Basel)202642793030PubTator, text miningPubMed
Endothelial Filamin C Alleviates Atherosclerosis via PINK1/Parkin-Dependent Mitophagy and mtDNA-cGAS-STING Inflammation Suppression.J Cardiovasc Dev Dis202642783035PubTator, text miningPubMed
SEME enables programmable transcript reconstruction through synthetic microexon incorporation.bioRxiv202642779617PubTator, text miningPubMed
Identification of novel and known variants in GAA, MYH6, NEXN, ATA3A, RHBDF1, and ACTA1 genes in coronary artery disease patients by Whole-exome sequencing.Front Cardiovasc Med202642760933PubTator, text miningPubMed
Extraction-dependent changes in immunoglobulin E binding profiles of processed lesser mealworm (Alphitobius diaperinus) proteins.J Sci Food Agric202642745438PubTator, text miningPubMed
Childhood-Onset Filamin c Related Cardiomyopathy: Genotype-Phenotype Correlation and Outcome.Clin Genet202642733184PubTator, text miningPubMed
Prevalence of Pathogenic Genetic Variants Across Heart Failure Etiologies in an Admixed Population.JACC Adv202642658137PubTator, text miningPubMed

1 to 10 of 3,704

See all 3,704 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2318

GET https://conductscience.org/api/genes/v1/2318/patents?page=2