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Gene · 23186

RCOR1: REST corepressor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RCOR1: REST corepressor 1. Genes, record 23186. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/23186

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Gene

Symbol
RCOR1
HGNC
Name
REST corepressor 1
HGNC
NCBI Gene ID
23186
NCBI Gene
HGNC ID
HGNC:17441
HGNC
Ensembl
ENSG00000089902
NCBI Gene
Aliases
COREST, KIAA0071, RCOR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UKL0REST corepressor 1485103Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4828973 A22026-10-2856Q9UKL0Espacenet
EP 4805378 A12026-09-16567Q9UKL0Espacenet
JP 2026523341 A2026-07-141026Q9UKL0Espacenet
EP 4771137 A12026-07-08564Q9UKL0Espacenet
EP 4771157 A12026-07-08564Q9UKL0Espacenet
US 12649003 B22026-06-091026Q9UKL0Espacenet
JP 2026510339 A2026-04-02564Q9UKL0Espacenet
EP 4713451 A22026-03-25564Q9UKL0Espacenet
EP 4713452 A22026-03-25564Q9UKL0Espacenet
US 12558437 B22026-02-241026Q9UKL0Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,838

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRCOR1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
P30CA042014Cancer Center Support Grant72025
R35GM149229Chemical Approaches to Understanding Reversible Lysine Modifications72025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer52025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA016087Cancer Center Support Grant52025
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)42025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA093373Cancer Center Support Grant P3042025

1 to 10 of 1,838Source NIH's project files

See all 1,838 nih grants

Papers2,104

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
REST in the Central Nervous System: Context-Dependent Regulation of Neuronal Homeostasis and Disease.Int J Dev Neurosci202642827376PubTator, text miningPubMed
Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome.Mol Cell Proteomics202642680104PubTator, text miningPubMed
Structure-Guided Optimization of a Molecular Glue Targeting the KBTBD4-HDAC1/2 Complex.ChemMedChem202642642754PubTator, text miningPubMed
Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability.Cancer Gene Ther202642576054PubTator, text miningPubMed
The CoREST complex inhibitor, corin, decreases tumor growth, increases cellular differentiation and extends lifespan in ATRT xenograft models.Neuro Oncol202642479134PubTator, text miningPubMed
DNA Methylation and Proteomic Profiling of Postmortem Brain Tissue Reveals Epigenetic Dysregulation and Neuroinflammatory in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS).bioRxiv202642465430PubTator, text miningPubMed
Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.Nucleic Acids Res202642376816PubTator, text miningPubMed
The Reconstitution of the Macrophage Niche Reveals Dynamic Transcriptional and Renal Macrophage-Epithelial Communication Networks.Cells202642346129PubTator, text miningPubMed
Reduced FBXO22 skews human trophoblast fate equilibrium toward syncytialization via polyubiquitinating the CoREST complex.Nucleic Acids Res202642240618PubTator, text miningPubMed
NANOG Proximity Proteomics Maps Neighborhood Hubs Linked to Mesenchymal Stem Cell Stemness and Chromatin Control.Biomolecules202642072652PubTator, text miningPubMed

1 to 10 of 2,104

See all 2,104 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/23186

GET https://conductscience.org/api/genes/v1/23186/patents?page=2